公开(公告)号：US20070141619A1

公开(公告)日：2007-06-21

申请号：US11674429

申请日：2007-02-13

申请人： Hideya KOMATANI ,  Yoshikazu Hara ,  Hidehito Kotani ,  Rinako Nakagawa

发明人： Hideya KOMATANI ,  Yoshikazu Hara ,  Hidehito Kotani ,  Rinako Nakagawa

IPC分类号： C12Q1/68 ,  A61K31/407

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705

摘要： The present invention relates to a protein which excretes cancer chemotherapeutic drugs from a cell and which confers drug-resistance on the cell, a DNA encoding the protein, a method for detecting a cell type resistant to cancer chemotherapeutic drugs, a method for screening an inhibitor to overcome the resistance to cancer chemotherapeutic drugs as well as utilizing this knowledge to improve the therapeutic treatment of cancer patients.

摘要翻译： 本发明涉及从细胞分泌癌症化学治疗药物并赋予细胞耐药性的蛋白质，编码该蛋白质的DNA，检测对癌症化学治疗药物有抗性的细胞类型的方法，筛选抑制剂的方法 克服对癌症化疗药物的抵抗力，并利用这一知识来改善癌症患者的治疗方法。

公开(公告)号：US06752076B2

公开(公告)日：2004-06-22

申请号：US09920651

申请日：2001-08-03

申请人： Yoshikazu Hara

发明人： Yoshikazu Hara

IPC分类号： B42M112

CPC分类号： B41L13/06 ,  B41L13/16 ,  B41M1/12 ,  B41M2205/16

摘要： A stencil printing machine (10) having plural printing drums and a control method thereof can perform correctly a stencil printing process so that even if one or more errors occur in a printing drum (1 or 2) which is not used in the current printing process, another printing drum (1 or 2) is used.

摘要翻译： 具有多个印刷鼓的模版印刷机（10）及其控制方法可以正确地执行模版印刷处理，使得即使在当前印刷处理中未使用的印刷鼓（1或2）中发生一个或多个错误 ，使用另一个印刷鼓（1或2）。

公开(公告)号：US06508168B1

公开(公告)日：2003-01-21

申请号：US09630547

申请日：2000-08-01

申请人： Yasuhiro Takahashi ,  Hideaki Nogi ,  Yoshikazu Hara ,  Koichi Oyama

发明人： Yasuhiro Takahashi ,  Hideaki Nogi ,  Yoshikazu Hara ,  Koichi Oyama

IPC分类号： B41L1300

CPC分类号： B41L13/06

摘要： A stencil printer includes a printing drum which has an ink-permeable peripheral wall and is rotated about a predetermined axis of rotation with a stencil master wound around the peripheral wall, a back press roll which associates with the printing drum to nip and convey a printing paper, and an internal press roll which is provided in the printing drum to be movable back and forth toward and away from the back press roll and pushes the peripheral wall of the printing drum toward the back press roll. An internal press roll drive mechanism moves back and forth the internal press roll between a first position where the internal press roll is held away from the back press roll and a second position at a distance from the first position toward the back press roll and is able to freely change the distance between the axis of rotation of the printing drum and the second position.

摘要翻译： 模版印刷机包括一个印刷滚筒，该印刷滚筒具有一个可透墨的外围壁，并且围绕着围绕周壁的一个模版母卷围绕预定的旋转轴旋转;背压辊，其与印刷滚筒相关联以夹持和传送印刷 纸和内压辊，其设置在印刷滚筒中，以可反向和远离背压辊移动并将印刷鼓的周壁推向后压辊。 内压辊驱动机构在内压辊与背压辊之间保持第一位置和从第一位置朝向背压辊一定距离的第二位置之间来回移动内压辊，并且能够 以便自由地改变印版滚筒的旋转轴线与第二位置之间的距离。

公开(公告)号：US5699731A

公开(公告)日：1997-12-23

申请号：US687949

申请日：1996-07-26

申请人： Yoshikazu Hara

发明人： Yoshikazu Hara

IPC分类号： B41L13/18 ,  B41F31/02 ,  B41L13/06 ,  B41L27/10 ,  G01F23/26 ,  B41F15/40

CPC分类号： B41L13/06 ,  B41L27/10 ,  Y10S101/45

摘要： In a stencil printing machine, when quantity of ink supplied into an ink supplying section in a rotary cylindrical drum is smaller than a predetermine value, ink complementing means is driven to supply ink from an ink storing container into the ink supplying section, and when the quantity of ink in the ink supplying section does not reach the predetermined value within an ink-complementing-means operation time, a determination is made that no ink is left in the ink storing container, and a warning signal is produced. The stencil printing machine comprises: a quantity-of-ink detector for detecting whether or not the quantity of ink in the ink supplying section has reached the predetermined value; a kind-of-ink detector for detecting the kind of ink supplied into the ink supplying section in the rotary cylindrical drum; and controller which operates to change, according to the kind of ink detected by the kind-of-ink detector, the ink-complementing-operation time which elapses until a determination is made that no ink is left in the ink storing container.

摘要翻译： 在模版印刷机中，当供给到旋转圆柱形滚筒中的供墨部分的墨水量小于预定值时，驱动墨水补充装置以将油墨从储墨容器供应到供墨部分中，并且当 墨水供应部分中的墨水量在墨水补充装置操作时间内未达到预定值，确定墨水储存容器中没有墨水被留下，并且产生警告信号。 模版印刷机包括：墨量检测器，用于检测供墨部分中的墨量是否达到预定值; 一种墨水检测器，用于检测供应到旋转圆柱形滚筒中的墨水供应部分的墨水的种类; 以及控制器，其操作以根据墨水检测器检测到的墨水的种类改变墨水补充操作时间，直到确定在墨水储存容器中没有墨水被留下。

公开(公告)号：US5642663A

公开(公告)日：1997-07-01

申请号：US599356

申请日：1996-02-09

申请人： Yoshikazu Hara

发明人： Yoshikazu Hara

IPC分类号： B41L13/04 ,  B41L13/06 ,  B41L13/16 ,  B41L35/06

CPC分类号： B41L35/06 ,  B41L13/06 ,  B41P2213/802

摘要： In a stencil printing machine, when a printing drum is set at its operating position in the direction of its axis, a drum switch is turned on, and a locking piece is engaged with a groove formed in an engaging rod integral with the printing drum, so that a lock switch is also turned on. In the case where the printing drum pushed into the printing machine is not at the operating position, the drum presence/absence switch is turned on, and the locking piece is not engaged with the groove, so that the lock switch is off. In this case, the locking piece is reciprocated a predetermined distance in both directions. As a result, the locking piece is engaged with the groove of the engaging rod; that is, the printing drum is moved axially to the operating position.

摘要翻译： 在模版印刷机中，当印刷滚筒在其轴线方向设置在其操作位置时，滚筒开关被打开，并且锁定件与形成在与印刷滚筒一体的接合杆中的凹槽接合， 使得锁定开关也被接通。 在打印机推入印刷机的情况下不在工作位置的情况下，滚筒存在/不存在开关被打开，并且锁定件未与凹槽接合，从而锁定开关关闭。 在这种情况下，锁定件在两个方向上往复运动预定距离。 结果，锁定件与接合杆的槽接合; 也就是说，印刷鼓轴向移动到操作位置。

公开(公告)号：US5608496A

公开(公告)日：1997-03-04

申请号：US332032

申请日：1994-11-01

申请人： Hiroshi Hanzawa ,  Yoshikazu Hara ,  Masakazu Miyata

发明人： Hiroshi Hanzawa ,  Yoshikazu Hara ,  Masakazu Miyata

IPC分类号： B41L13/04 ,  B41F33/02 ,  B41F33/14 ,  B41L13/06 ,  G03G21/00

CPC分类号： B41L13/06 ,  B41F33/02

摘要： In order to indicate more distinctly the results of transverse and longitudinal adjustments of a print image, in a printer image position indicating device, a standard print position indication mark showing a printing master being positioned at the standard position relative to a print sheet and a biased print position indication mark showing a biased position of the printing master in either or both of the transverse and longitudinal directions relative to the standard position are expressed as marks each including at least two straight lines perpendicular to one another, and the biased print position indication mark is biased in the transverse and/or longitudinal directions according to a corresponding biasing of the printing master relative to the print sheet. The standard print position mark and the biased print position mark are expressed by different kinds of lines so as to clearly contrast one against the other. In addition, the biased print position indication mark is biased at a greater rate than a ratio of a biasing amount of the printing master from the standard position to the site of the printing master.

摘要翻译： 为了更清楚地指出打印图像的横向和纵向调整的结果，在打印机图像位置指示装置中，标示打印位置指示标记表示打印主机相对于打印纸定位在标准位置，并且偏置 在相对于标准位置的横向和纵向方向中的一个或两个中显示打印母版的偏置位置的打印位置指示标记被表示为标记，每个标记包括彼此垂直的至少两条直线，以及偏置的打印位置指示标记 根据印刷主体相对于打印片材的相应偏置在横向和/或纵向方向上偏置。 标准打印位置标记和偏置的打印位置标记由不同种类的线表示，以便清楚地对比一个。 此外，偏置的打印位置指示标记以比打印母版的偏压量与标准位置与打印母版的位置的比率更大的偏差。

公开(公告)号：US06640702B2

公开(公告)日：2003-11-04

申请号：US09849488

申请日：2001-05-07

申请人： Hiroshi Watanabe ,  Yoshikazu Hara

发明人： Hiroshi Watanabe ,  Yoshikazu Hara

IPC分类号： B41F1504

CPC分类号： B41L13/06

摘要： A stencil printing machine is provided as including first and second printing drums 25 and 26 carrying thereon respective screens30, a press drum 27 located in close proximity to the printing drums and a stencil making unit 9. In a control method, the stencil making unit 9 supplies a perforated stencil sheet 11a onto a selected printing drum 25 and a non-perforated stencil sheet 11b onto a non-selected printing drum 26, wherein a print sheet 41 clamped to the press drum 27 is transferred along an outer periphery of the press drum 27 to allow the perforated stencil sheet of the first printing drum 25 to transfer printing ink with a first color to the print sheet 41 while the non-perforated stencil sheet mounted onto the second printing drum prevents printing ink to be transferred to the print sheet 41.

摘要翻译： 提供了一种模版印刷机，其包括承载有相应屏幕的第一和第二印刷鼓25和26，位于印刷鼓附近的压力鼓27和模版加工单元9.在控制方法中，模版加工单元9 将未经选择的印版滚筒25和未穿孔的蜡纸11b上的穿孔蜡纸11a提供到未选择的印刷滚筒26上，其中夹紧在压鼓27上的打印纸41沿印刷滚筒的外周传送 以允许第一印版滚筒25的穿孔的蜡纸将第一种颜色的印刷油墨转印到印刷纸41上，同时安装在第二印刷鼓上的非穿孔的蜡纸防止印刷油墨转移到印刷纸41上 。

公开(公告)号：US06382093B1

公开(公告)日：2002-05-07

申请号：US09472507

申请日：1999-12-27

申请人： Yoshikazu Hara

发明人： Yoshikazu Hara

IPC分类号： B41L1306

CPC分类号： B41L31/00

摘要： A stencil printing machine in which a stencil is sheared off of a continuous roll of stencil sheet to a length determined by a selected size of printing paper, mounted onto a printing drum, removed from said printing drum, and transported to and inserted into a used stencil container by a transport means, which comprises a stencil length specifying means which specifies the length of the stencil according to a selected size of printing paper when the stencil is prepared for printing, and a control means which controls an operation amount of the transport means, at the time the stencil is removed from the printing drum, in relation to the length of the stencil as specified by the stencil length specifying means. The control means may comprise a random access memory to record the data from the stencil length specifying mechanism. The operation amount of the transport means can be related to rotation angle of the printing drum, and operation of the transport means may be terminated by detection of a rotational angle of said printing drum at which said used stencil is completely transported and deposited into said used stencil container can be detected.

摘要翻译： 一种模版印刷机，其中将模板从连续的一张蜡纸上剪切到由选定尺寸的印刷纸确定的长度，所述长度安装到印刷鼓上，从所述印刷鼓上移除并被输送并被插入到所使用的 模板容器，其包括模板长度指定装置，当模板准备打印时，该模板长度指定装置根据所选择的打印纸尺寸指定模版的长度;以及控制装置，其控制输送装置的操作量 相对于模板长度指定装置规定的模板的长度，在从印版滚筒移除模板时。 控制装置可以包括随机存取存储器，以从模板长度指定机构记录数据。 传送装置的操作量可以与印版滚筒的旋转角度有关，并且传送装置的操作可以通过检测所述打印滚筒的旋转角度来终止，在该旋转角度下，所述使用的模板被完全输送并沉积到所述使用过的 可以检测出模板容器。

公开(公告)号：US6038968A

公开(公告)日：2000-03-21

申请号：US134545

申请日：1998-08-17

申请人： Yoshikazu Hara ,  Katsuro Motoe ,  Hisashi Sanagi

发明人： Yoshikazu Hara ,  Katsuro Motoe ,  Hisashi Sanagi

IPC分类号： B41L13/04 ,  B41L13/06 ,  B41L13/10 ,  B41L13/16

CPC分类号： B41L13/06 ,  B41L13/16

摘要： In a stencil printer, a printing drum is provided with a clamp plate for clamping an end portion of a stencil master, thereby holding the stencil master on the printing drum. A paper supply mechanism supplies printing sheets to the printing drum in synchronization with rotation of the printing drum. A first motor drives the paper supply mechanism by way of a first transmission mechanism, and a second transmission mechanism is operatively connected to the first transmission mechanism to be driven by the first motor by way of the first transmission mechanism, thereby rotating the printing drum. A phase adjustment mechanism driven by a second motor drives the second transmission mechanism with the first transmission mechanism held stopped, thereby changing the relative phases of rotation of the printing drum and sheet supply operation of the paper supply means. A drum position sensor generates a detecting signal upon detection that the printing drum comes to a reference position. The first motor is driven to rotate the printing drum and is stopped upon generation of the detecting signal. Then the second motor is driven to rotate the printing drum to the reference position.

摘要翻译： 在模版印刷机中，印刷滚筒设置有用于夹紧模板母版的端部的夹板，从而将印版主机保持在印版滚筒上。 纸张供给机构与印刷鼓的旋转同步地向打印鼓提供印刷纸。 第一电动机通过第一传动机构驱动供纸机构，第二传动机构可操作地连接到第一传动机构，由第一传动机构由第一传动机构驱动，从而转动印版滚筒。 由第二电动机驱动的相位调节机构驱动第二传动机构，第一传动机构保持停止，从而改变印版滚筒的相对转动和供纸装置的供纸操作。 鼓位置传感器在检测到印刷鼓进入基准位置时产生检测信号。 第一马达被驱动以旋转印版滚筒，并在产生检测信号时停止。 然后驱动第二马达将印版滚筒旋转到基准位置。

公开(公告)号：USD378930S

公开(公告)日：1997-04-22

申请号：US49032

申请日：1996-01-16

申请人： Fujio Nobata ,  Yoshikazu Hara

设计人： Fujio Nobata ,  Yoshikazu Hara