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14 条记录 (耗时 0.018 秒)

    Heterocyclic compounds and antitumor drugs containing the same as the active ingredient
    8.
    发明申请
    Heterocyclic compounds and antitumor drugs containing the same as the active ingredient 有权
    含有与活性成分相同的杂环化合物和抗肿瘤药物

    公开(公告)号：US20060009440A1

    公开(公告)日：2006-01-12

    申请号：US10532245

    申请日：2003-10-24

    申请人： Seiichiro Kawashima ,  Toshiyuki Matsuno ,  Shinichi Yaguchi ,  Yoshio Tsuchida ,  Kenichi Saitoh ,  Hiroya Sasahara ,  Tetsuo Watanabe

    发明人： Seiichiro Kawashima ,  Toshiyuki Matsuno ,  Shinichi Yaguchi ,  Yoshio Tsuchida ,  Kenichi Saitoh ,  Hiroya Sasahara ,  Tetsuo Watanabe

    IPC分类号： A61K31/33

    CPC分类号： A61K31/5377 ,  C07D403/04 ,  C07D403/14

    摘要： The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1-C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) or NR6R7 [R6 represents C1-C6 alkyl and R7 represents piperidinyl (which may be substituted with C1-C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1-C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl) when R1 is hydroxyl

    摘要翻译： 本发明涉及由式I表示的杂环化合物，其中X表示氮原子或CH; R 1表示卤素原子或羟基; R 2表示氢原子，羟基或氨基; R 3表示吗啉代（其可以被一个或两个C 1 -C 6烷基取代），吡咯烷基（其可以被羟基 C 1 -C 6烷基）或NR 6 R 7 - [R 6 - 表示C 1 -C 6烷基，R 7表示哌啶基（其可以被C 1 -C 6烷基取代） 烷基）]; R 4和R 5各自代表氢原子或C 1 -C 6烷基，条件是R R 2是氢原子，R 3是吡咯烷基（其可以被羟基C 1 -C 6烷基取代） ）当R 1为羟基时

    Axially centering apparatus for fusion-bonding optical fibers
    10.
    发明授权
    Axially centering apparatus for fusion-bonding optical fibers 失效

    公开(公告)号：US5168617A

    公开(公告)日：1992-12-08

    申请号：US688389

    申请日：1991-04-22

    申请人： Yoshio Tsuchida ,  Tomoki Takahashi ,  Shuji Kajitani

    发明人： Yoshio Tsuchida ,  Tomoki Takahashi ,  Shuji Kajitani

    IPC分类号： G02B6/255 ,  G02B6/38 ,  G02B21/06

    CPC分类号： G02B6/2557 ,  G02B21/06 ,  G02B6/2551 ,  Y10T29/53961 ,  Y10T29/53978

    摘要： An axially centering apparatus for fusion-bonding optical fibers comprising a pair of guides having long grooves on the upper surfaces thereof for engaging optical fibers, a pair of fulcra formed in parallel with the long grooves of the guides for supporting the guides, a pair of centering stands having substrates for supporting the fulcra, a pair of centering mechanisms having load imparting mechanism sections having telescopic output ends, load imparting mechanism sections, and transmitting mechanism sections for the adjusting mechanism sections so that the long grooves of said centering stands are disposed adjacent to each other to align in a rectilinear line, said centering mechanisms are associated with the centering stands to contact the output ends of the centering mechanisms with the guides of the centering stands, wherein said one centering stand satisfies the conditions that the fulcrum 3A and the long groove 4A are relatively positioned so that the crossing angle .alpha. (alpha) between a line segment AL.sub.1 and a perpendicular AL.sub.2 becomes 45.degree., where AO.sub.1 is the center of the fulcrum as seen from the plane perpendicular to the long groove, AO.sub.2 is the center of the long groove, AL.sub.1 is the line segment passing the centers AO.sub.1 and AO.sub.2, and AL.sub.2 is a perpendicular passing the center AO.sub.1 of the long groove, and similarly, the other centering stand satisfies the conditions that the crossing angle .beta. (beta) between a line segment LB.sub.1 and a perpendicular AL.sub.2 becomes 45.degree., where BO.sub.1 is the center of the fulcrum, BO.sub.2 is the center of the long groove, BL.sub.1 is the line segment passing the centers BO.sub.1 and BO.sub.2, and BL.sub.2 is a perpendicular passing the center BO.sub.1 of the long groove, and the pair of centering stands disposed adjacent to each other are perpendicularly crossed at both line segments AL.sub.1 and BL.sub.1, and the output ends of the pair of centering mechanisms are disposed on the same plane to be contacted with the guides of the centering stands.