公开(公告)号：US07781413B2

公开(公告)日：2010-08-24

申请号：US10285351

申请日：2002-10-31

Applicant: John Minna ,  Yoshio Tomizawa ,  Yoshitaka Sekido ,  Michael Lerman

Inventor： John Minna ,  Yoshio Tomizawa ,  Yoshitaka Sekido ,  Michael Lerman

IPC: A61K31/713

CPC classification number: A61K38/1709 ,  G01N33/57484

Abstract: The present invention identifies the semaphorin polypeptide SEMA3B as a tumor suppressor. This molecule can inhibit tumor growth and induce apoptosis of tumor cells when produced internally in a cancer cell via gene transfer, or when applied extracellularly. These observations permit new methods for treatment and diagnosis of cancer.

Abstract translation: 本发明将信号素多肽SEMA3B鉴定为肿瘤抑制因子。 当通过基因转移在癌细胞内部产生时，或当细胞外应用时，该分子可以抑制肿瘤生长并诱导肿瘤细胞凋亡。 这些观察结果允许用于治疗和诊断癌症的新方法。

公开(公告)号：US06441156B1

公开(公告)日：2002-08-27

申请号：US09470443

申请日：1999-12-22

Applicant: Michael Isaac Lerman ,  Farida Latif ,  Ming-Hui Wei ,  Fuh-Mei Duh ,  John Dorrance Minna ,  Yoshitaka Sekido ,  Boning Gao

Inventor： Michael Isaac Lerman ,  Farida Latif ,  Ming-Hui Wei ,  Fuh-Mei Duh ,  John Dorrance Minna ,  Yoshitaka Sekido ,  Boning Gao

IPC: C07H2102

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (&agr;2&dgr;) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.

Abstract translation: 本发明涉及钙通道组合物及其制备和使用方法。 特别地，本发明涉及钙通道α2δ（α2delta）亚基和编码它们的核酸序列。 这些组合物可用于鉴定调节钙通道活性并鉴定化合物作为疾病治疗的化合物的方法。

公开(公告)号：US06979724B2

公开(公告)日：2005-12-27

申请号：US10116949

申请日：2002-04-05

Applicant: Michael Isaac Lerman ,  Farida Latif ,  Ming-Hui Wei ,  Fuh-Mei Duh ,  John Dorrance Minna ,  Yoshitaka Sekido ,  Boning Gao

Inventor： Michael Isaac Lerman ,  Farida Latif ,  Ming-Hui Wei ,  Fuh-Mei Duh ,  John Dorrance Minna ,  Yoshitaka Sekido ,  Boning Gao

IPC: A61K38/00 ,  C07K14/705 ,  C07K14/435 ,  A61K38/17 ,  C07H21/04

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (α2δ) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.

Abstract translation: 本发明涉及钙通道组合物及其制备和使用方法。 特别地，本发明涉及钙通道α2δ（α2Δ3）亚基和编码它们的核酸序列。 这些组合物可用于鉴定调节钙通道活性并鉴定化合物作为疾病治疗的化合物的方法。