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公开(公告)号：US07977468B2
公开(公告)日：2011-07-12
申请号：US11932724
申请日：2007-10-31
Applicant: Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
Inventor： Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
CPC classification number: C12N15/86 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C07K14/4703 , C12N15/8509 , C12N2710/10343 , C12N2830/006 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , Y10S977/916
Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
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公开(公告)号：US07902441B2
公开(公告)日：2011-03-08
申请号：US10445718
申请日：2003-05-27
Applicant: Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
Inventor： Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
IPC: A61K48/00
CPC classification number: C12N15/86 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C07K14/4703 , C12N15/8509 , C12N2710/10343 , C12N2830/006 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , Y10S977/916
Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
Abstract translation: 肿瘤抑制基因在人类肺癌和其他癌症的发病机制中起主要作用。 新鲜肿瘤和肿瘤来源的细胞系的细胞遗传学和等位基因研究表明，染色体3（3p）短臂上的细胞遗传学变化和等位基因丢失最常见于约90％的小细胞肺癌和大于50％ - 细胞肺癌。 一组隐性致癌基因Fus1,101F6，基因21（NPRL2），基因26（CACNA2D2），Luca 1（HYAL1），Luca 2（HYAL2），PL6,123F2（RaSSFI），SEM A3和Beta *（BLU） 如在肺癌中的纯合缺失所定义的，已经在3p21.3定位和分离。
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公开(公告)号：US06979724B2
公开(公告)日：2005-12-27
申请号：US10116949
申请日：2002-04-05
Applicant: Michael Isaac Lerman , Farida Latif , Ming-Hui Wei , Fuh-Mei Duh , John Dorrance Minna , Yoshitaka Sekido , Boning Gao
Inventor： Michael Isaac Lerman , Farida Latif , Ming-Hui Wei , Fuh-Mei Duh , John Dorrance Minna , Yoshitaka Sekido , Boning Gao
IPC: A61K38/00 , C07K14/705 , C07K14/435 , A61K38/17 , C07H21/04
CPC classification number: C07K14/705 , A61K38/00
Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (α2δ) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.
Abstract translation: 本发明涉及钙通道组合物及其制备和使用方法。 特别地，本发明涉及钙通道α2δ（α2Δ3）亚基和编码它们的核酸序列。 这些组合物可用于鉴定调节钙通道活性并鉴定化合物作为疾病治疗的化合物的方法。
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Patent Agency Ranking
公开(公告)号：US20090023207A1
公开(公告)日：2009-01-22
申请号：US11932724
申请日：2007-10-31
Applicant: Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
Inventor： Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
CPC classification number: C12N15/86 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C07K14/4703 , C12N15/8509 , C12N2710/10343 , C12N2830/006 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , Y10S977/916
Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
Abstract translation: 肿瘤抑制基因在人类肺癌和其他癌症的发病机制中起主要作用。 新鲜肿瘤和肿瘤来源的细胞系的细胞遗传学和等位基因研究表明，染色体3（3p）短臂上的细胞遗传学变化和等位基因丢失最常见于约90％的小细胞肺癌和大于50％ - 细胞肺癌。 一组隐性致癌基因Fus1,101F6，基因21（NPRL2），基因26（CACNA2D2），Luca 1（HYAL1），Luca 2（HYAL2），PL6,123F2（RaSSFI），SEM A3和Beta *（BLU） 如在肺癌中的纯合缺失所定义的，已经在3p21.3定位和分离。
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公开(公告)号：US09944951B2
公开(公告)日：2018-04-17
申请号：US13114921
申请日：2011-05-24
Applicant: Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
Inventor： Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
CPC classification number: C12N15/86 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C07K14/4703 , C12N15/8509 , C12N2710/10343 , C12N2830/006 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , Y10S977/916
Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
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6.发明申请公开(公告)号：US20110207217A1
公开(公告)日：2011-08-25
申请号：US12750201
申请日：2010-03-30
Applicant: David Reid Corey , Bethany Ann Janowski , David S. Shames , John Dorrance Minna
Inventor： David Reid Corey , Bethany Ann Janowski , David S. Shames , John Dorrance Minna
IPC: C12N5/02
CPC classification number: C12N15/63 , A61K48/005 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/331 , C12N2320/50 , C12N2310/3521
Abstract: Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
Abstract translation: 通过使细胞与基因的靶启动子内的区域互补的12-28个碱基的多核苷酸寡聚体接触，在哺乳动物细胞中选择性地增加基因的靶转录物的合成，由此寡聚体选择性地增加靶的合成 成绩单
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公开(公告)号：US06441156B1
公开(公告)日：2002-08-27
申请号：US09470443
申请日：1999-12-22
Applicant: Michael Isaac Lerman , Farida Latif , Ming-Hui Wei , Fuh-Mei Duh , John Dorrance Minna , Yoshitaka Sekido , Boning Gao
Inventor： Michael Isaac Lerman , Farida Latif , Ming-Hui Wei , Fuh-Mei Duh , John Dorrance Minna , Yoshitaka Sekido , Boning Gao
IPC: C07H2102
CPC classification number: C07K14/705 , A61K38/00
Abstract: The present invention relates to calcium channel compositions and methods of making and using same. In particular, the invention relates to calcium channel alpha2delta (&agr;2&dgr;) subunits and nucleic acid sequences encoding them. These compositions are useful in methods for identifying compounds that modulate the activity of calcium channels and for identifying compounds as therapeutic for disease.
Abstract translation: 本发明涉及钙通道组合物及其制备和使用方法。 特别地，本发明涉及钙通道α2δ（α2delta）亚基和编码它们的核酸序列。 这些组合物可用于鉴定调节钙通道活性并鉴定化合物作为疾病治疗的化合物的方法。
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公开(公告)号：US20120076851A1
公开(公告)日：2012-03-29
申请号：US13114921
申请日：2011-05-24
Applicant: Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
Inventor： Lin Ji , John Dorrance Minna , Jack Roth , Michael Lerman
IPC: A61K31/711 , A61K9/127 , A61P35/00 , A61K31/7048 , A61K31/713 , C12N5/09 , A61K33/24
CPC classification number: C12N15/86 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0331 , A61K48/00 , C07K14/4703 , C12N15/8509 , C12N2710/10343 , C12N2830/006 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , Y10S977/916
Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
Abstract translation: 肿瘤抑制基因在人类肺癌和其他癌症的发病机制中起主要作用。 新鲜肿瘤和肿瘤来源的细胞系的细胞遗传学和等位基因研究表明，染色体3（3p）短臂上的细胞遗传学变化和等位基因丢失最常见于约90％的小细胞肺癌和大于50％ - 细胞肺癌。 一组隐性致癌基因Fus1,101F6，基因21（NPRL2），基因26（CACNA2D2），Luca 1（HYAL1），Luca 2（HYAL2），PL6,123F2（RaSSFI），SEM A3和Beta *（BLU） 如在肺癌中的纯合缺失所定义的，已经在3p21.3定位和分离。
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