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公开(公告)号：US5320853A
公开(公告)日：1994-06-14
申请号：US995309
申请日：1992-12-22
申请人： Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino , David D. MacLaren , Paul F. Skultety , John R. Lefler , Greg M. Beck
发明人： Kazuo Noda , Yoshiyuki Hirakawa , Hiroyuki Yoshino , David D. MacLaren , Paul F. Skultety , John R. Lefler , Greg M. Beck
IPC分类号： A61K9/52 , A61K9/50 , A61K9/54 , A61K9/58 , A61K31/554 , A61K47/12 , A61K47/20 , A61P9/12 , A61K9/24
CPC分类号： A61K9/5078
摘要： Controlled release pharmaceutical beads are provided having a multi-layered core and a multi-layered periphery. The core contains at least (A) an inner portion having a suitable organic acid and (B) a sustainably-acid-releasing coating thereover. The periphery contains at least (A) an inner portion having a mixture of at least (i) a pharmaceutical compound and (ii) a surface-active agent, and (B) a sustainably-drug-releasing exterior coating.
摘要翻译： 提供具有多层芯和多层外围的控释药物珠粒。 核心至少包含（A）具有合适的有机酸的内部部分和（B）其上可持续发酸的涂层。 外围至少包含（A）具有至少（i）药物化合物和（ii）表面活性剂的混合物的内部部分，和（B）可持续释放药物的外部涂层。
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2.发明授权
公开(公告)号：US5395628A
公开(公告)日：1995-03-07
申请号：US870195
申请日：1992-04-13
CPC分类号： A61K9/5078
摘要： A controlled release pharmaceutical preparation comprising (a) a core containing a pharmaceutically active substance and an organic acid, and (b) a coating film formed on the surface of the core by aqueous coating of a water-insoluble and water-slightly permeable acrylic polymer containing a trimethylammonium-ethyl group, which exhibits well controlled dissolution and release of the pharmaceutically active substance when administered and can maintain the desired blood level of the active substance for a long period of time, and a method for producing the preparation.
摘要翻译： 一种控释药物制剂，其包含（a）含有药物活性物质和有机酸的核心，和（b）通过水不溶性和水 - 微透性丙烯酸类聚合物的水性涂层形成在芯的表面上的涂膜 其含有三甲基铵 - 乙基，其在施用时表现出良好控制的药物活性物质的溶解和释放，并且可以长时间保持活性物质的期望血液水平，以及制备该制剂的方法。
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3.发明授权
公开(公告)号：US5254347A
公开(公告)日：1993-10-19
申请号：US729841
申请日：1991-07-12
CPC分类号： A61K9/2866 , A61K9/5078
摘要： Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Disclosed is also a method for producing the same. The controlled release pharmaceutical preparation of this invention posseses a desired dissolution rate by controlling the porosity of the porous film.
摘要翻译： 公开了一种控释药物制剂，其包含含有药物活性成分的核心和疏水聚合物质或疏水性聚合物质和亲水性聚合物质的多孔膜，所述核心被多孔膜涂覆。 也公开了其制造方法。 通过控制多孔膜的孔隙率，本发明的控释药物制剂具有所需的溶出速率。
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4.发明申请Request message control method for using service and service providing system 审中-公开使用服务和服务提供系统的请求消息控制方法公开(公告)号：US20060069777A1
公开(公告)日：2006-03-30
申请号：US11139648
申请日：2005-05-31
IPC分类号： G06F15/173
CPC分类号： H04L67/1008 , H04L67/02 , H04L67/04 , H04L67/1002 , H04L67/2814 , H04L67/327
摘要： In the case where Web service providers and Web service brokers are successively connected in a multistage manner to form a tree structure, with each of the Web service brokers relaying messages to be transmitted and received between a Web service requestor and the Web service providers, not only the performance, states, and configurations of Web service providers which are directly called by a Web service broker, but also those of Web service providers existing in a descendant direction of the tree structure, are made use of as information used to determine a Web service provider to which a request message should be transmitted.
摘要翻译： 在Web服务提供商和Web服务经纪人以多级方式连续形成树形结构的情况下，每个Web服务代理中继在Web服务请求者和Web服务提供商之间传送和接收的消息，而不是 只有由Web服务代理直接调用的Web服务提供商的性能，状态和配置，以及存在于树结构的后代方向上的Web服务提供者的性能，状态和配置被用作确定Web的信息 应向其发送请求消息的服务提供商。
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5.发明授权
公开(公告)号：US5068112A
公开(公告)日：1991-11-26
申请号：US329408
申请日：1989-03-24
CPC分类号： A61K9/5078 , A61K9/2866
摘要： Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Disclosed is also a method for producing the same. The controlled release pharmaceutical preparation of this invention posseses a desired dissolution rate by controlling the porosity of the porous film.
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6.发明授权
公开(公告)号：US5725880A
公开(公告)日：1998-03-10
申请号：US402052
申请日：1995-03-10
CPC分类号： A61K9/2846 , A61K9/2866
摘要： A pharmaceutical preparation for oral administration which is controlled to release a medicinal active ingredient at a targeted site in the intestinal tract comprising (a) a core containing a medicinal active ingredient and (b) a press-coated layer comprising an enteric polymer, said layer being provided around the core. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after discharged from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.
摘要翻译： 一种用于口服给药的药物制剂，其被控制以在肠道中的靶位点上释放药物活性成分，其包含（a）含有药用活性成分的核心和（b）包含肠溶性聚合物的加压包衣层，所述层 围绕核心提供。 在本发明的药物制剂中，药物活性成分在胃停留期间不释放，并且在从胃排出后直到达到肠内的目标部位，然后迅速释放，使得药用活性成分 有效地输送到肠道中的目标部位。
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7.发明授权
公开(公告)号：US5614220A
公开(公告)日：1997-03-25
申请号：US385982
申请日：1995-02-09
CPC分类号： A61K9/2886
摘要： A pharmaceutical preparation for oral administration comprising(a) a core containing a medicinal active ingredient,(b) a press-coated layer comprising a pH-independently water-soluble polymer, said layer being provided around the core and(c) a film comprising an enteric polymer, said film being provided around the press-coated layer. In the pharmaceutical preparation of the present invention, the medicinal active ingredient is not released during residence in the stomach and, after forwarded from the stomach, until reaching a targeted site in the intestine, and thereafter is quickly released, so that the medicinal active ingredient is efficiently delivered to the targeted site in the intestinal tract.
摘要翻译： 一种用于口服给药的药物制剂，其包含（a）含有药用活性成分的核心，（b）包含pH独立的水溶性聚合物的压制涂层，所述层围绕所述芯设置，（c）包含 肠溶性聚合物，所述膜设置在压制涂层周围。 在本发明的药物制剂中，药物活性成分在胃停留期间不会释放，并且在从胃部转移到达肠道的目标部位之后不被释放，然后迅速释放，使得药物活性成分 有效地输送到肠道中的目标部位。
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公开(公告)号：US4966899A
公开(公告)日：1990-10-30
申请号：US143769
申请日：1988-01-14
CPC分类号： A61K9/19 , A61K31/43 , A61K47/02 , A61K9/0019
摘要： An antibacterial lyophilized preparation which comprises as an active ingredient aspoxicillin and a basic salt of aspoxicillin in a molar ratio of 1 : about 0.7 to 7 and optionally an alkali metal halide as a stabilizer, and a method for preparing the same, said antibacterial lyophilized preparation being able to be rapidly dissolved in distilled water to give a stable solution which can be injected to patients for the treatment of various bacterial infectious diseases.
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