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    Multi-leaf collimator device for radiotherapy
    1.
    发明授权
    Multi-leaf collimator device for radiotherapy 有权
    用于放射治疗的多叶准直器装置

    公开(公告)号：US08917816B2

    公开(公告)日：2014-12-23

    申请号：US13582297

    申请日：2011-03-03

    申请人： Young Hoon Ji ,  Hai Jo Jung ,  Kum Bae Kim ,  Mun Sik Choi ,  Seung Woo Park

    发明人： Young Hoon Ji ,  Hai Jo Jung ,  Kum Bae Kim ,  Mun Sik Choi ,  Seung Woo Park

    IPC分类号： A61N5/10 ,  G21K1/04

    CPC分类号： A61N5/1045 ,  G21K1/046 ,  Y10T74/18096

    摘要： A multi-leaf collimator device for radiotherapy, including: a frame that has a box shape and has through-holes formed in top and bottom surfaces thereof; a plurality of collimators that are received in the frame, wherein each of the collimators includes a rack gear formed on the top surface of the collimator, the collimators are symmetrically arranged in a left-right direction about a central portion of the frame, and are slidably provided on the frame; and a motion driving unit that includes a pinion gear that is formed to be detachable from the rack gear formed on the top surface of the collimator, and is provided on the frame to move the pinion gear in a front-back direction of the frame and an up-down direction of the frame.

    摘要翻译： 一种用于放射治疗的多叶准直器装置，包括：框架，其具有盒形并且在其顶表面和底表面上形成有通孔; 多个准直器，其被接收在所述框架中，其中每个所述准直器包括形成在所述准直器的顶表面上的齿条，所述准直器围绕所述框架的中心部分在左右方向上对称布置，并且是准直器 可滑动地设置在框架上; 以及运动驱动单元，其包括小齿轮，所述小齿轮形成为能够从形成在所述准直仪的上表面上的齿条拆卸，并且设置在所述框架上以沿所述框架的前后方向移动所述小齿轮; 框架的上下方向。

    MULTI-LEAF COLLIMATOR DEVICE FOR RADIOTHERAPY
    2.
    发明申请
    MULTI-LEAF COLLIMATOR DEVICE FOR RADIOTHERAPY 有权
    用于放射治疗的多叶缩血管装置

    公开(公告)号：US20130000428A1

    公开(公告)日：2013-01-03

    申请号：US13582297

    申请日：2011-03-03

    申请人： Young Hoon Ji ,  Hai Jo Jung ,  Kum Bae Kim ,  Mun Sik Choi ,  Seung Woo Park

    发明人： Young Hoon Ji ,  Hai Jo Jung ,  Kum Bae Kim ,  Mun Sik Choi ,  Seung Woo Park

    IPC分类号： F16H19/04

    CPC分类号： A61N5/1045 ,  G21K1/046 ,  Y10T74/18096

    摘要： A multi-leaf collimator device for radiotherapy, including: a frame that has a box shape and has through-holes formed in top and bottom surfaces thereof; a plurality of collimators that are received in the frame, wherein each of the collimators includes a rack gear formed on the top surface of the collimator, the collimators are symmetrically arranged in a left-right direction about a central portion of the frame, and are slidably provided on the frame; and a motion driving unit that includes a pinion gear that is formed to be detachable from the rack gear formed on the top surface of the collimator, and is provided on the frame to move the pinion gear in a front-back direction of the frame and an up-down direction of the frame.

    摘要翻译： 一种用于放射治疗的多叶准直器装置，包括：框架，其具有盒形并且在其顶表面和底表面上形成有通孔; 多个准直器，其被接收在所述框架中，其中每个所述准直器包括形成在所述准直器的顶表面上的齿条，所述准直器围绕所述框架的中心部分在左右方向上对称布置，并且是准直器 可滑动地设置在框架上; 以及运动驱动单元，其包括小齿轮，所述小齿轮形成为能够从形成在所述准直仪的上表面上的齿条拆卸，并且设置在所述框架上以沿所述框架的前后方向移动所述小齿轮; 框架的上下方向。

    Anti-inflammatory composition containing macrolactin A and a derivative thereof as active ingredients
    3.
    发明授权
    Anti-inflammatory composition containing macrolactin A and a derivative thereof as active ingredients 有权
    含有促乳素A及其衍生物作为活性成分的抗炎组合物

    公开(公告)号：US09089543B2

    公开(公告)日：2015-07-28

    申请号：US13321112

    申请日：2010-05-24

    申请人： Young-Hoon Ji ,  Dong-Hee Kim ,  Jae-Seon Kang ,  Chun-Gyu Kim ,  Sung-Uk Chung ,  Sung-Woo Hwang ,  Kyung-Ran Kang

    发明人： Young-Hoon Ji ,  Dong-Hee Kim ,  Jae-Seon Kang ,  Chun-Gyu Kim ,  Sung-Uk Chung ,  Sung-Woo Hwang ,  Kyung-Ran Kang

    IPC分类号： A61K31/335 ,  A61K31/365

    CPC分类号： A61K31/335 ,  A61K31/365

    摘要： The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines. Therefore, the macrolactin compounds produced by the Bacillus polyfermenticus KJS-2 strain according to the present invention can provide excellent anti-inflammatory agents.

    摘要翻译： 本发明涉及由新生芽孢杆菌（Bacillus polyfermenticus）KJS-2（KCCM10769P）的芽孢杆菌菌株生产的大多数内消旋用途的大多数乳糖素A，7-O-丙二酰基大内酰胺A和7-O-琥珀酰基大内酰胺素A ）。 证实本发明提供的大内酰胺化合物能够大大抑制与形成炎症介质相关的蛋白质的诱导型一氧化氮合成酶（iNOS）和环氧合酶-2（COX-2）的表达和形成，并因此抑制 形成一氧化氮（NO）和作为蛋白质代谢物的前列腺素E2（PGE2）。 此外，本发明提供的大多数内消旋化合物被证实在抑制肿瘤坏死因子-α（TNF-α），白细胞介素-1和bgr的形成方面具有优异的效果。 （IL-1和bgr），白介素-6（IL-6）和粒细胞巨噬细胞集落刺激因子（GM-CSF），其是促炎细胞因子。 因此，本发明的由芽孢杆菌属多发性支原体KJS-2株产生的大分子内酯化合物可提供优异的抗炎剂。

    ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS
    5.
    发明申请
    ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS 有权
    含有MACROLACTIN A及其衍生物作为活性成分的抗炎组合物

    公开(公告)号：US20120071549A1

    公开(公告)日：2012-03-22

    申请号：US13321112

    申请日：2010-05-24

    申请人： Young-Hoon Ji ,  Dong-Hee Kim ,  Jae-Seon Kang ,  Chun-Gyu Kim ,  Sung-Uk Chung ,  Sung-Woo Hwang ,  Kyung-Ran Kang

    发明人： Young-Hoon Ji ,  Dong-Hee Kim ,  Jae-Seon Kang ,  Chun-Gyu Kim ,  Sung-Uk Chung ,  Sung-Woo Hwang ,  Kyung-Ran Kang

    IPC分类号： A61K31/365 ,  C12P17/08 ,  A61P29/00 ,  C07D313/00

    CPC分类号： A61K31/335 ,  A61K31/365

    摘要： The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and formation of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF), which are pro-inflammatory cytokines. Therefore, the macrolactin compounds produced by the Bacillus polyfermenticus KJS-2 strain according to the present invention can provide excellent anti-inflammatory agents.

    摘要翻译： 本发明涉及由新生芽孢杆菌（Bacillus polyfermenticus）KJS-2（KCCM10769P）的芽孢杆菌菌株生产的大多数内消旋用途的大多数乳糖素A，7-O-丙二酰基大内酰胺素A和7-O-琥珀酰基大内酰胺素A ）。 证实本发明提供的大内酰胺化合物能够大大抑制与形成炎症介质相关的蛋白质的诱导型一氧化氮合成酶（iNOS）和环氧合酶-2（COX-2）的表达和形成，并因此抑制 形成一氧化氮（NO）和作为蛋白质代谢物的前列腺素E2（PGE2）。 此外，本发明提供的大多数内消旋化合物被证实在抑制肿瘤坏死因子-α（TNF-α），白细胞介素-1和bgr的形成方面具有优异的效果。 （IL-1和bgr），白介素-6（IL-6）和粒细胞巨噬细胞集落刺激因子（GM-CSF），其是促炎细胞因子。 因此，本发明的由芽孢杆菌属多发性支原体KJS-2株产生的大分子内酯化合物可提供优异的抗炎剂。

    PORTABLE PHANTOM DEVICE
    6.
    发明申请
    PORTABLE PHANTOM DEVICE 审中-公开
    便携式设备

    公开(公告)号：US20140336439A1

    公开(公告)日：2014-11-13

    申请号：US14361287

    申请日：2012-08-28

    申请人： Young Hoon Ji ,  Hyun Do Huh ,  Sang Hyoun Choi ,  Hai Jo Jung ,  Kum Bae Kim

    发明人： Young Hoon Ji ,  Hyun Do Huh ,  Sang Hyoun Choi ,  Hai Jo Jung ,  Kum Bae Kim

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1075 ,  A61N2005/1076

    摘要： A portable phantom device according to the present invention is a phantom device which is detachably installed in a bird cage that is coupled to an irradiator, and includes a body provided with an accommodation space having a cylindrical shape and a top of which is open so as to accommodate water, a horizontality adjustment maintaining portion which is detachably coupled to a side wall of the body; and a sensor holding portion which is installed on the side wall of the body so as not to interfere with the horizontality adjustment maintaining portion, so that a sensor for measuring the amount of radiation that is incident on the accommodation space may be inserted from the outside of the body and accommodated in the body (Representative drawing: FIG. 2)

    摘要翻译： 根据本发明的便携式幻影装置是一种幻影装置，其可拆卸地安装在联接到照射器的鸟笼中，并且包括主体，该主体设置有具有圆柱形状的容纳空间，其顶部是敞开的，以便 以容纳水，水平调节保持部分，其可拆卸地联接到身体的侧壁; 以及传感器保持部，其安装在本体的侧壁上，以便不干扰水平调节保持部分，从而可以从外部插入用于测量入射到容纳空间的辐射量的传感器 的身体（代表图：图2）

    RADIOTHERAPEUTIC SYSTEM AND METHOD PERFORMED BY NON-INVASIVE AND REAL-TIME TUMOR POSITION TRACKING
    8.
    发明申请
    RADIOTHERAPEUTIC SYSTEM AND METHOD PERFORMED BY NON-INVASIVE AND REAL-TIME TUMOR POSITION TRACKING 审中-公开
    放射治疗系统和非侵入性和实时肿瘤位置跟踪方法

    公开(公告)号：US20100119443A1

    公开(公告)日：2010-05-13

    申请号：US12614444

    申请日：2009-11-08

    申请人： Young Hoon JI ,  Hai Jo JUNG ,  Kum Bae KIM ,  Seung Woo PARK

    发明人： Young Hoon JI ,  Hai Jo JUNG ,  Kum Bae KIM ,  Seung Woo PARK

    IPC分类号： A61K51/00 ,  A61B6/00

    CPC分类号： A61N5/1049 ,  A61B6/12 ,  A61B6/4258 ,  A61B2090/392 ,  A61N5/1042 ,  A61N5/1067 ,  A61N2005/1051

    摘要： A radiotherapeutic system including non-invasive and real-time tumor tracking includes: a signal detector for detecting radioactive rays emitted from a tumor to which the radioactive medical supply is adsorbed and generating an electrical signal; a signal processor for converting the electrical signal generated into a three-dimensional (3D) coordinate signal; a controller for generating a control signal in conjunction with the 3D coordinate signal output by the signal processor; and a radioactive-ray irradiation device for emitting radioactive rays to the tumor, wherein the amount of the radioactive rays is controlled by the controller.

    摘要翻译： 包括非侵入性和实时肿瘤追踪的放射治疗系统包括：信号检测器，用于检测从放射性医疗用品被吸收的肿瘤发射的放射线，并产生电信号; 用于将生成的电信号转换成三维（3D）坐标信号的信号处理器; 控制器，用于结合由信号处理器输出的3D坐标信号产生控制信号; 以及用于向肿瘤发射放射线的放射线照射装置，其中放射线的量由控制器控制。

    COLLIMATOR DEVICE FOR RADIOTHERAPY AND RADIOTHERAPY APPARATUS USING THE SAME
    9.
    发明申请
    COLLIMATOR DEVICE FOR RADIOTHERAPY AND RADIOTHERAPY APPARATUS USING THE SAME 审中-公开
    使用放射疗法和放射治疗装置的收缩器装置

    公开(公告)号：US20090220046A1

    公开(公告)日：2009-09-03

    申请号：US12361153

    申请日：2009-01-28

    申请人： Young Hoon JI ,  Dong Han LEE ,  Mon Sik CHOI ,  Seung Woo PARK ,  Yoon Jong KIM

    发明人： Young Hoon JI ,  Dong Han LEE ,  Mon Sik CHOI ,  Seung Woo PARK ,  Yoon Jong KIM

    IPC分类号： A61N5/10 ,  G21K1/04

    CPC分类号： A61N5/1042 ,  G21K1/04 ,  G21K1/046

    摘要： Provided is a collimator device for radiotherapy including: a body including a first through unit and disposed on a path of high energy radiation which in use is irradiated toward a patient's treatment part; a frame including a through hole corresponding to the first through unit and slidably installed in the body; a plurality of multi-leaf collimators (MLCs) slidably installed in the through hole and including radiation shields; a servo motor coupled to the body and the frame in a power manner so as to slidingly move the frame with respect to the body; and a motor controller externally receiving position displacement data regarding a motion of the patient's treatment part due to a patient's breathing and generating a signal for controlling the driving of the servo motor so that the MLCs follow the patient's treatment part and continuously apply radiation to the patient's treatment part based on the position displacement data.

    摘要翻译： 本发明提供一种放射线用准直器装置，包括：主体，包括第一通孔单元，并设置在使用中朝向患者治疗部分照射的高能辐射路径上; 框架，其包括与所述第一通孔单元对应的通孔，并且可滑动地安装在所述主体中; 多个多叶准直器（MLC），可滑动地安装在通孔中并包括辐射屏蔽; 伺服电动机以电力方式联接到主体和框架，以便相对于主体滑动地移动框架; 以及电动机控制器，由于患者的呼吸而外部接收关于患者治疗部分的运动的位置位移数据，并产生用于控制伺服电动机的驱动的信号，使得MLCs跟随患者的治疗部分并且持续地向病人的治疗部分施加辐射 治疗部位基于位置位移数据。