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    Method of acquiring immunological tolerance
    2.
    发明授权
    Method of acquiring immunological tolerance 失效
    获得免疫耐受的方法

    公开(公告)号：US07671250B2

    公开(公告)日：2010-03-02

    申请号：US11812762

    申请日：2007-06-21

    申请人： Yousuke Takahama

    发明人： Yousuke Takahama

    IPC分类号： A61K48/00 ,  A01K67/027 ,  C12N5/10

    CPC分类号： C12N15/86 ,  A01K67/0271 ,  A01K2217/05 ,  A61K48/00 ,  C12N2740/13043

    摘要： The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be recognized not as non-self but as self; a method of sustaining a gene therapeutic effect whereby a rejection to a foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be avoided; and a non-human animal which has acquired immunological tolerance to a foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product. Fetal immature T lymphocytes transferred with a foreign DNA, such as a foreign gene-incorporated viral vector, are introduced into thymus and said foreign DNA is expressed in the thymus organ. The methods of transferring said foreign DNA into a fetal immature T lymphocyte include, for example, co-cultivating the fetal immature T lymphocytes with viral vector-infected virus producer cells.

    摘要翻译： 本发明的目的是提供一种获得对外来DNA或其表达产物的免疫耐受性的方法，其中外源DNA如携带外源基因的载体或其表达产物可被认为不是非自身但是 作为自我; 维持基因治疗效果的方法，可以避免外源DNA的排斥，例如载有外源基因的载体或其表达产物; 以及对携带外源基因的载体或其表达产物等外源DNA具有免疫耐受性的非人动物。 将外源DNA转移的胎儿未成熟T淋巴细胞如外源基因并入病毒载体导入胸腺，外源DNA在胸腺器官中表达。 将外源DNA转移到胎儿未成熟T淋巴细胞中的方法包括例如用病毒载体感染的病毒生产细胞共培养胎儿未成熟T淋巴细胞。

    EVALUATION APPARATUS OF FLUORESCENCE POPULATION, EVALUATION METHOD OF FLUORESCENCE POPULATION AND COMPUTER READABLE STORAGE MEDIUM
    4.
    发明申请
    EVALUATION APPARATUS OF FLUORESCENCE POPULATION, EVALUATION METHOD OF FLUORESCENCE POPULATION AND COMPUTER READABLE STORAGE MEDIUM 有权
    荧光人口评估装置，荧光人口评估方法和计算机可读存储介质

    公开(公告)号：US20110211741A1

    公开(公告)日：2011-09-01

    申请号：US12979858

    申请日：2010-12-28

    申请人： Yoshitaro NAKANO ,  Yousuke TAKAHAMA ,  Takeshi NITTA

    发明人： Yoshitaro NAKANO ,  Yousuke TAKAHAMA ,  Takeshi NITTA

    IPC分类号： G06K9/00

    CPC分类号： G01N15/1463 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/6458 ,  G01N2015/1443

    摘要： Statistical data of a fluorescence population is obtained easily with high accuracy. To achieve this, an evaluation apparatus of fluorescence population of the present application includes an input unit inputting a fluorescence observation image (If) of a fluorescence population and a transillumination observation image (It) having a same field of view as the fluorescence observation image, a first detecting unit (Mt) detecting, as a first area, an area in which a cellular image exists on the transillumination observation image being input, a setting unit (If′) setting, as a reference area, an area corresponding to the first area on the fluorescence observation image being input, and an obtaining unit obtaining fluorescence intensity data of a fluorescence image from the reference area in the fluorescence observation image.

    摘要翻译： 以高精度容易地获得荧光群体的统计学数据。 为了实现这一点，本申请的荧光群的评价装置包括输入荧光群的荧光观察图像（If）的输入单元和与荧光观察图像具有相同视场的透照观察图像（It） 第一检测单元（Mt）作为第一区域检测正在输入的透照观察图像上存在蜂窝图像的区域，设置单元（If'）设置作为参考区域，与第一区域相对应的区域 输入荧光观察图像的面积，以及从荧光观察图像中的参考区域获取荧光图像的荧光强度数据的获取单元。

    Method of acquiring immunological tolerance
    5.
    发明申请
    Method of acquiring immunological tolerance 失效
    获得免疫耐受的方法

    公开(公告)号：US20080010694A1

    公开(公告)日：2008-01-10

    申请号：US11812762

    申请日：2007-06-21

    申请人： Yousuke Takahama

    发明人： Yousuke Takahama

    IPC分类号： A01K67/00

    CPC分类号： C12N15/86 ,  A01K67/0271 ,  A01K2217/05 ,  A61K48/00 ,  C12N2740/13043

    摘要： The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be recognized not as non-self but as self, a method of sustaining a gene therapeutic effect whereby a rejection to a foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be avoided; and a non-human animal which has acquired immunological tolerance to a foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product. Immature T lymphocytes transferred with a foreign DNA, such as a foreign gene-incorporated viral vector, are introduced into thymus and said foreign DNA is expressed in the thymus organ. The methods of transferring said foreign DNA into a immature T lymphocyte include, for example, co-cultivating the immature T lymphocytes with viral vector-infected virus producer cells.

    摘要翻译： 本发明的目的是提供一种获得对外来DNA或其表达产物的免疫耐受性的方法，其中外源DNA如携带外源基因的载体或其表达产物可被认为不是非自体但是 作为自身，可以避免基因治疗效果的方法，从而可以避免外源DNA的排斥，例如携带外源基因的载体或其表达产物; 以及对携带外源基因的载体或其表达产物等外源DNA具有免疫耐受性的非人动物。 用外来DNA转移的未成熟T淋巴细胞如外源基因并入病毒载体被引入胸腺，并且所述外源DNA在胸腺器官中表达。 将外源DNA转移到未成熟T淋巴细胞的方法包括例如用病毒载体感染的病毒生产细胞共培养未成熟T淋巴细胞。

    Method of acquiring immunological tolerance
    6.
    发明授权
    Method of acquiring immunological tolerance 失效
    获得免疫耐受的方法

    公开(公告)号：US07276234B1

    公开(公告)日：2007-10-02

    申请号：US09889321

    申请日：2000-09-19

    申请人： Yousuke Takahama

    发明人： Yousuke Takahama

    IPC分类号： A61K48/00 ,  C12N5/00 ,  C12N15/63

    CPC分类号： C12N15/86 ,  A01K67/0271 ,  A01K2217/05 ,  A61K48/00 ,  C12N2740/13043

    摘要： The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be recognized not as non-self but as self; a method of sustaining a gene therapeutic effect whereby a rejection to a foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product can be avoided; and a non-human animal which has acquired immunological tolerance to a foreign DNA such as a vector carrying a foreign gene incorporated thereinto or its expression product. Fetal immature T lymphocytes transferred with a foreign DNA, such as a foreign gene-incorporated viral vector, are introduced into thymus and said foreign DNA is expressed in the thymus organ. The methods of transferring said foreign DNA into a fetal immature T lymphocyte include, for example, co-cultivating the fetal immature T lymphocytes with viral vector-infected virus producer cells.

    摘要翻译： 本发明的目的是提供一种获得对外来DNA或其表达产物的免疫耐受性的方法，其中外源DNA如携带外源基因的载体或其表达产物可被认为不是非自体但是 作为自我; 维持基因治疗效果的方法，可以避免外源DNA的排斥，例如载有外源基因的载体或其表达产物; 以及对携带外源基因的载体或其表达产物等外源DNA具有免疫耐受性的非人动物。 将外源DNA转移的胎儿未成熟T淋巴细胞如外源基因并入病毒载体导入胸腺，外源DNA在胸腺器官中表达。 将外源DNA转移到胎儿未成熟T淋巴细胞中的方法包括例如用病毒载体感染的病毒生产细胞共培养胎儿未成熟T淋巴细胞。

    Evaluation apparatus of fluorescence population, evaluation method of fluorescence population and computer readable storage medium
    7.
    发明授权
    Evaluation apparatus of fluorescence population, evaluation method of fluorescence population and computer readable storage medium 有权
    荧光群体评估装置，荧光群体评估方法和计算机可读存储介质

    公开(公告)号：US08588502B2

    公开(公告)日：2013-11-19

    申请号：US12979858

    申请日：2010-12-28

    申请人： Yoshitaro Nakano ,  Yousuke Takahama ,  Takeshi Nitta

    发明人： Yoshitaro Nakano ,  Yousuke Takahama ,  Takeshi Nitta

    IPC分类号： G06K9/00 ,  G06K9/46

    CPC分类号： G01N15/1463 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/6458 ,  G01N2015/1443

    摘要： Statistical data of a fluorescence population is obtained easily with high accuracy. To achieve this, an evaluation apparatus of fluorescence population of the present application includes an input unit inputting a fluorescence observation image (If) of a fluorescence population and a transillumination observation image (It) having a same field of view as the fluorescence observation image, a first detecting unit (Mt) detecting, as a first area, an area in which a cellular image exists on the transillumination observation image being input, a setting unit (If′) setting, as a reference area, an area corresponding to the first area on the fluorescence observation image being input, and an obtaining unit obtaining fluorescence intensity data of a fluorescence image from the reference area in the fluorescence observation image.

    摘要翻译： 以高精度容易地获得荧光群体的统计学数据。 为了实现这一点，本申请的荧光群的评价装置包括输入荧光群的荧光观察图像（If）的输入单元和与荧光观察图像具有相同视场的透照观察图像（It） 第一检测单元（Mt）作为第一区域检测正在输入的透照观察图像上存在蜂窝图像的区域，设置单元（If'）设置作为参考区域，与第一区域相对应的区域 输入荧光观察图像的面积，以及从荧光观察图像中的参考区域获取荧光图像的荧光强度数据的获取单元。