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1.发明申请公开(公告)号：US20110159551A1
公开(公告)日：2011-06-30
申请号：US12900794
申请日：2010-10-08
申请人： Lei (a.k.a Larry) Xi , Roland Nagel , Stephen Hendricks , Jennifer Berkman , Marian Peris , Yulei Wang
发明人： Lei (a.k.a Larry) Xi , Roland Nagel , Stephen Hendricks , Jennifer Berkman , Marian Peris , Yulei Wang
CPC分类号： C12N9/1276 , C12N15/1096 , C12Q2521/107 , C12Y207/07049
摘要： The present invention provides compositions and methods for a reverse transcription reaction using a reversibly inactivated reverse transcriptase enzyme. The reversibly inactivated reverse transcriptase enzyme results from a chemical modification which inactivates the reverse transcriptase enzyme. The activity of the reverse transcriptase enzyme is recovered by an incubation of the reaction mixture at elevated temperature prior to, or as part of the reverse transcription reaction. The reverse transcriptase enzyme of the present invention provides for a signficant reduction in non-specific reverse transcription from template nucleic acid molecules because the formulation of the reaction mixture does not support the formation of reverse transcription products prior to activation of the reverse transcriptase.
摘要翻译： 本发明提供使用可逆失活的逆转录酶进行逆转录反应的组合物和方法。 可逆灭活的逆转录酶由化学修饰产生，其使逆转录酶失活。 通过在反转录反应之前或作为逆转录反应的一部分的升高温度下温育反应物来回收逆转录酶的活性。 本发明的逆转录酶提供了明显减少模板核酸分子的非特异性逆转录，因为反应混合物的配方不支持在逆转录酶激活之前形成逆转录产物。
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2.发明申请公开(公告)号：US20090029868A1
公开(公告)日：2009-01-29
申请号：US11981143
申请日：2007-10-30
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N2800/329
摘要： We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA.
摘要翻译： 我们假设外周血细胞中的基因表达模式可能与TAA疾病状态相关，并对从TAA患者和正常个体获得的外周血细胞进行综合基因表达调查。 外周血细胞中不同的基因表达谱可以分类来自正常个体的TAA患者。 本教导提供的基因定义了一组诊断标记，从而提供了一种基于血液的基因表达测试，以促进TAA疾病的早期检测。 还提供了区分上升TAA的方法，以及区分家族与散发性TAA的方法。
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3.发明申请公开(公告)号：US20130006342A1
公开(公告)日：2013-01-03
申请号：US13611240
申请日：2012-09-12
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N2800/329
摘要： We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA.
摘要翻译： 我们假设外周血细胞中的基因表达模式可能与TAA疾病状态相关，并对从TAA患者和正常个体获得的外周血细胞进行综合基因表达调查。 外周血细胞中不同的基因表达谱可以分类来自正常个体的TAA患者。 本教导提供的基因定义了一组诊断标记，从而提供了一种基于血液的基因表达测试，以促进TAA疾病的早期检测。 还提供了区分上升TAA的方法，以及区分家族与散发性TAA的方法。
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公开(公告)号：US20070276688A1
公开(公告)日：2007-11-29
申请号：US11746005
申请日：2007-05-08
申请人： Tongyu Sun , Yulei Wang , Dong Chai , Peng Jiang , Anning Li , Jianfeng Zhang , Lijuan Chen
发明人： Tongyu Sun , Yulei Wang , Dong Chai , Peng Jiang , Anning Li , Jianfeng Zhang , Lijuan Chen
CPC分类号： G06Q30/08 , G06Q10/063114 , G06Q30/02 , G06Q30/0282
摘要： Interactive resource competition ranks resource users using coefficients of performance (CoP). Resource users compete for a target resource and each offer a quantifiable reciprocal resource in exchange for using the target resource. A trigger frequency of a predetermined action with respect to the target resource is recorded, and the CoP based on the respective reciprocal resource value and the trigger frequency is determined. The target resource is then allocated based on the ranking of the CoP's. An intermediate and credit fund account is used for both making payments and recording the trigger frequency. The competition is particularly useful for allocating an information display position in online electronic marketing.
摘要翻译： 互动资源竞争使资源用户使用绩效系数（CoP）进行排名。 资源用户竞争目标资源，并且每个都提供可量化的互惠资源，以交换使用目标资源。 记录关于目标资源的预定动作的触发频率，并且确定基于相应的互惠资源值和触发频率的CoP。 然后根据CoP的排名分配目标资源。 中间和信用资金账户用于支付和记录触发频率。 比赛对于在线电子营销中分配信息显示位置特别有用。
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