公开(公告)号：US11872202B2

公开(公告)日：2024-01-16

申请号：US17695741

申请日：2022-03-15

申请人： Chengyuan Liang ,  Xiuding Yang ,  Liang Xin ,  Juan Xia ,  Yuqing Zhao ,  Jie Zhang ,  Lei Tian ,  Jingyi Li ,  Shaojun Zhang ,  Qianqian Zhao

发明人： Chengyuan Liang ,  Xiuding Yang ,  Liang Xin ,  Juan Xia ,  Yuqing Zhao ,  Jie Zhang ,  Lei Tian ,  Jingyi Li ,  Shaojun Zhang ,  Qianqian Zhao

IPC分类号： A61K31/216 ,  A61P31/04

CPC分类号： A61K31/216 ,  A61P31/04

摘要： A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)




R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

公开(公告)号：US11518740B2

公开(公告)日：2022-12-06

申请号：US17239575

申请日：2021-04-24

申请人： Qianqian Zhao ,  Jie Zhang ,  Liang Xin ,  Jingyi Li ,  Ruina Bian ,  Yuqing Zhao ,  Dan Yang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang

发明人： Qianqian Zhao ,  Jie Zhang ,  Liang Xin ,  Jingyi Li ,  Ruina Bian ,  Yuqing Zhao ,  Dan Yang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang

IPC分类号： C07C323/52 ,  C07C319/20

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220348540A1

公开(公告)日：2022-11-03

申请号：US17239582

申请日：2021-04-24

申请人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Ruina BIAN ,  Jie ZHANG ,  Qianqian ZHAO ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

发明人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Ruina BIAN ,  Jie ZHANG ,  Qianqian ZHAO ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

IPC分类号： C07C323/52 ,  A61P31/04 ,  C07C319/28

摘要： A compound with anti-drug resistant bacteria activity having the formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20230172889A1

公开(公告)日：2023-06-08

申请号：US17695741

申请日：2022-03-15

申请人： Chengyuan LIANG ,  Liang XIN ,  Juan XIA ,  Yuqing ZHAO ,  Jie ZHANG ,  Lei TIAN ,  Jingyi LI ,  Shaojun ZHANG ,  Qianqian ZHAO

发明人： Chengyuan LIANG ,  Liang XIN ,  Juan XIA ,  Yuqing ZHAO ,  Jie ZHANG ,  Lei TIAN ,  Jingyi LI ,  Shaojun ZHANG ,  Qianqian ZHAO

IPC分类号： A61K31/216 ,  A61P31/04

CPC分类号： A61K31/216 ,  A61P31/04

摘要： A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)




R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

公开(公告)号：US11510905B1

公开(公告)日：2022-11-29

申请号：US17239583

申请日：2021-04-24

申请人： Chengyuan Liang ,  Wenjing Yang ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Ruina Bian ,  Jie Zhang ,  Yuqing Zhao ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Liang Qi ,  Gennian Mao

发明人： Chengyuan Liang ,  Wenjing Yang ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Ruina Bian ,  Jie Zhang ,  Yuqing Zhao ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Liang Qi ,  Gennian Mao

IPC分类号： C07D233/60 ,  A61K31/4164 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20240132631A1

公开(公告)日：2024-04-25

申请号：US18163103

申请日：2023-02-01

申请人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

发明人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

IPC分类号： C08B37/00 ,  C12P19/04

CPC分类号： C08B37/0024 ,  C08B37/0003 ,  C12P19/04

摘要： The invention provides a preparation method of high-content Ganoderma lucidum β-glucan and an efficient and rapid detection method thereof. The preparation method comprises ethanol-trypsin pretreatment of Ganoderma lucidum fruiting body in combination with ultrasonic-assisted alkaline hydrothermal extraction of β-glucan from Ganoderma lucidum, and purifying β-glucan by DEAE Sephadex A-25 Sephadex column chromatography using NAOH solution as a mobile phase, to obtain high purity (≥90%) of Ganoderma lucidum β-glucan. The detection method comprises placing the extracted β-glucan in an autoclave and performing hydrolysis with β-(1,3)-exo-glucanase and β-glucosidase, and detecting and analyzing the content of the prepared β-glucan by high pressure-acid enzymatic hydrolysis-HPLC method, using glucose as a standard. The preparation method of β-glucan has high extraction ratio. The efficient and rapid detection method has high sensitivity, high accuracy and good repeatability, and thus has a wide application prospect.

公开(公告)号：US11512049B2

公开(公告)日：2022-11-29

申请号：US17239582

申请日：2021-04-24

申请人： Qianqian Zhao ,  Yuqing Zhao ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Ruina Bian ,  Jie Zhang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang ,  Liang Qi ,  Gennian Mao

发明人： Qianqian Zhao ,  Yuqing Zhao ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Ruina Bian ,  Jie Zhang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang ,  Liang Qi ,  Gennian Mao

IPC分类号： C07C323/52 ,  A61P31/04 ,  C07C319/28

摘要： A compound with anti-drug resistant bacteria activity having the formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220354826A1

公开(公告)日：2022-11-10

申请号：US17239583

申请日：2021-04-24

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

IPC分类号： A61K31/4164 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220348539A1

公开(公告)日：2022-11-03

申请号：US17239575

申请日：2021-04-24

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Dan YANG ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Dan YANG ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG

IPC分类号： C07C323/52 ,  C07C319/20

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20240228673A9

公开(公告)日：2024-07-11

申请号：US18163103

申请日：2023-02-01

申请人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

发明人： Yinjun HOU ,  Hua Li ,  Qian Gao ,  Yongbo Wang ,  Xiuding Yang ,  Yue Gao ,  Yuqing Zhao ,  Jie Zhang ,  Chengyuan Liang

IPC分类号： C08B37/00 ,  C12P19/04

CPC分类号： C08B37/0024 ,  C08B37/0003 ,  C12P19/04

摘要： The invention provides a preparation method of high-content Ganoderma lucidum β-glucan and an efficient and rapid detection method thereof. The preparation method comprises ethanol-trypsin pretreatment of Ganoderma lucidum fruiting body in combination with ultrasonic-assisted alkaline hydrothermal extraction of β-glucan from Ganoderma lucidum, and purifying β-glucan by DEAE Sephadex A-25 Sephadex column chromatography using NAOH solution as a mobile phase, to obtain high purity (≥90%) of Ganoderma lucidum β-glucan. The detection method comprises placing the extracted β-glucan in an autoclave and performing hydrolysis with β-(1,3)-exo-glucanase and β-glucosidase, and detecting and analyzing the content of the prepared β-glucan by high pressure-acid enzymatic hydrolysis-HPLC method, using glucose as a standard. The preparation method of β-glucan has high extraction ratio. The efficient and rapid detection method has high sensitivity, high accuracy and good repeatability, and thus has a wide application prospect.