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    Means for creating a mass having structural integrity
    2.
    发明授权
    Means for creating a mass having structural integrity 有权
    用于创造具有结构完整性的物体的方法

    公开(公告)号：US06465010B1

    公开(公告)日：2002-10-15

    申请号：US09902751

    申请日：2001-07-12

    申请人： Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

    发明人： Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

    IPC分类号： A61K920

    CPC分类号： A61K9/0056 ,  A61K9/1623 ,  A61K9/1658 ,  A61K9/2081 ,  Y10S514/96 ,  Y10S514/961

    摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.

    摘要翻译： 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。

    Means for creating a mass having structural integrity
    3.
    发明授权
    Means for creating a mass having structural integrity 失效
    用于创造具有结构完整性的物体的方法

    公开(公告)号：US06284270B1

    公开(公告)日：2001-09-04

    申请号：US09366686

    申请日：1999-08-04

    申请人： Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

    发明人： Yury Lagoviyer ,  R. Saul Levinson ,  Denis Stotler ,  Thomas C. Riley

    IPC分类号： A61K920

    CPC分类号： A61K9/0056 ,  A61K9/1623 ,  A61K9/1658 ,  A61K9/2081 ,  Y10S514/96 ,  Y10S514/961

    摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.

    摘要翻译： 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。

    COMPOSITIONS FOR ORAL DELIVERY OF PHARMACEUTICALS
    5.
    发明申请
    COMPOSITIONS FOR ORAL DELIVERY OF PHARMACEUTICALS 审中-公开
    用于口服药物输送的组合物

    公开(公告)号：US20080181932A1

    公开(公告)日：2008-07-31

    申请号：US12021438

    申请日：2008-01-29

    申请人： Jonathan David Bortz ,  Paul Timothy Brady ,  Yury Lagoviyer

    发明人： Jonathan David Bortz ,  Paul Timothy Brady ,  Yury Lagoviyer

    IPC分类号： A61K9/50 ,  A61K38/43 ,  A61K9/52 ,  A61K9/00 ,  A61P43/00

    CPC分类号： A61K9/1676

    摘要： The invention provides methods and compositions for the oral delivery of pharmaceutically active agents. In particular, the compositions generally comprise a plurality of pharmaceutically active agents embedded in a matrix that is substantially erodable when contacted with an aqueous medium. The compositions may also include an inner core comprising an inert material. The compositions may be introduced into the oral cavity of a subject by liquid beverage or food product comprising a composition of the invention.

    摘要翻译： 本发明提供了用于口服递送药物活性剂的方法和组合物。 特别地，组合物通常包含嵌入基质中的多种药学活性剂，当与水性介质接触时，其基本上可侵蚀。 组合物还可以包括包含惰性材料的内核。 组合物可以通过包含本发明组合物的液体饮料或食品引入受试者的口腔。