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公开(公告)号：US08859011B2
公开(公告)日：2014-10-14
申请号：US11746832
申请日：2007-05-10
CPC分类号： A61K9/2059 , A23L29/015 , A23L33/16 , A23P10/25 , A23V2002/00 , A61K9/16 , A61K9/2027 , A61K33/10 , Y10S514/96 , A23V2250/1578 , A23V2250/7106
摘要： Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
摘要翻译： 提供了包含碳酸钙的组合物及其制备方法。 本发明提供了一种颗粒，其包含约95重量％至约99重量％的碳酸钙，约0.5重量％至约5重量％的粘合剂和约0.03重量％至约3重量％的孔隙率增加剂。 由这种造粒剂制备的药物或营养组合物包含约90％至约99％重量的碳酸钙，约0.03％至约3％重量的孔隙率增加剂和约1％至约10％重量的其它 赋形剂。 组合物提供比常规碳酸钙组合物更小的片剂，以改善容易吞咽。
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公开(公告)号：US06465010B1
公开(公告)日：2002-10-15
申请号：US09902751
申请日：2001-07-12
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/2081 , Y10S514/96 , Y10S514/961
摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.
摘要翻译： 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。
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公开(公告)号：US06284270B1
公开(公告)日：2001-09-04
申请号：US09366686
申请日：1999-08-04
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/2081 , Y10S514/96 , Y10S514/961
摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.
摘要翻译： 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。
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公开(公告)号：US20070264329A1
公开(公告)日：2007-11-15
申请号：US11746832
申请日：2007-05-10
CPC分类号： A61K9/2059 , A23L29/015 , A23L33/16 , A23P10/25 , A23V2002/00 , A61K9/16 , A61K9/2027 , A61K33/10 , Y10S514/96 , A23V2250/1578 , A23V2250/7106
摘要： Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
摘要翻译： 提供了包含碳酸钙的组合物及其制备方法。 本发明提供了一种颗粒，其包含约95重量％至约99重量％的碳酸钙，约0.5重量％至约5重量％的粘合剂和约0.03重量％至约3重量％的孔隙率增加剂。 由这种造粒制备的药物或营养组合物包含约90％至约99％重量的碳酸钙，约0.03％至约3％重量的孔隙率增加剂和约1％至约10％重量的其它 赋形剂。 组合物提供比常规碳酸钙组合物更小的片剂，以改善容易吞咽。
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