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公开(公告)号：US06465010B1
公开(公告)日：2002-10-15
申请号：US09902751
申请日：2001-07-12
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/2081 , Y10S514/96 , Y10S514/961
摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.
摘要翻译： 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。
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公开(公告)号：US06284270B1
公开(公告)日：2001-09-04
申请号：US09366686
申请日：1999-08-04
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/1623 , A61K9/1658 , A61K9/2081 , Y10S514/96 , Y10S514/961
摘要： The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water. The process comprising dissolving at least one bulking agent and at least one structural agent in a suitable solvent, wherein the solvent provides high porosity upon drying; spray-drying or dispersing said dissolved mixture to obtain a bead or granulated product; dry blending at least one binding agent, and at least one active ingredient with the bead or granulated product to obtain a preformulation product or adding at least one active ingredient to the preformulation product dissolved or dispersed components before spray-drying or dispersing; compressing the preformulation product; and sintering or heating the preformulation product for a sufficient time and temperature to allow the binding agent to change status or melt and allow the binding agent to resolidify as the temperature is reduced to ambient temperature.
摘要翻译： 本发明涉及一种用于产生具有结构完整性的组合物的装置，包括用于在使用或不使用水的情况下施用的快速崩解片剂。 本发明具有多种不同的用途和应用。 一个实施方案是用于口服给药的片剂。 片剂包含至少一种活性成分和赋形剂混合物。 赋形剂提供所需的特性和物理性质，并且当片剂被烧结或加热时，获得了优异的片剂结合特性。 片剂主要用于口服给药，并在水的存在下溶解。 还公开了制备用于或不使用水的快速崩解片剂的方法。 该方法包括将至少一种填充剂和至少一种结构剂溶解在合适的溶剂中，其中溶剂在干燥时提供高孔隙率; 喷雾干燥或分散所述溶解的混合物以获得珠粒或造粒产品; 将至少一种粘合剂和至少一种活性成分与珠粒或造粒产物干混以获得预配制品或在喷雾干燥或分散之前向预配制品溶解或分散的组分中加入至少一种活性成分; 压制预制品; 并且将预制化产品烧结或加热足够的时间和温度以允许粘合剂改变状态或熔化，并且当温度降低至环境温度时允许粘合剂重新固化。
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公开(公告)号：US20130102548A1
公开(公告)日：2013-04-25
申请号：US13555472
申请日：2012-07-23
IPC分类号： A61K9/00
CPC分类号： A61K9/0036 , A61K9/0034
摘要： A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 μg to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL·hr.
摘要翻译： 用于治疗人类患者的阴道病症的药物制剂包括：至少一种活性剂; 一种改良释放剂型，其在阴道给药时提供对抗感染药物的延长释放; 并且其中当基于活性剂含有约25至约500mg的总剂量的抗感染剂时，制剂将产生具有曲线下面积的血浆浓度对时间曲线（ng / mL对小时） （AUC）小于约600ng / mL·hr。
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公开(公告)号：US09789057B2
公开(公告)日：2017-10-17
申请号：US13555472
申请日：2012-07-23
IPC分类号： A61K9/00
CPC分类号： A61K9/0036 , A61K9/0034
摘要： A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 μg to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL·hr.
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公开(公告)号：US06899890B2
公开(公告)日：2005-05-31
申请号：US10101014
申请日：2002-03-20
IPC分类号： A61K9/10 , A61F6/06 , A61K9/00 , A61K31/4164 , A61K31/7028 , A61K45/00 , A61K47/12 , A61P5/24 , A61P15/00 , A61P15/02 , A61P15/18 , A61P31/04 , A61P33/02 , A61F13/02 , A61F6/14 , A61K9/107 , A61N25/34
CPC分类号： A61K47/12 , A61K9/0034 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a novel essentially pH neutral vaginal drug delivery system suitable for modified delivery of a therapeutically active material in the vaginal cavity. The vaginal drug delivery system comprises an essentially pH neutral emulsion having globules having two phases, an internal water soluble phase and an external water-insoluble phase or film, wherein the water-soluble interior phase contains a therapeutically active drug or drugs. One novel aspect of the vaginal drug delivery system is that the internal water soluble phase comprises an acidic buffered phase.
摘要翻译： 本发明涉及一种新颖的基本上pH为中性的阴道药物递送系统，其适于在阴道腔中修饰递送治疗活性物质。 阴道药物递送系统包括基本上具有两相球形的pH中性乳液，内部水溶性相和外部水不溶性相或膜，其中所述水溶性内相含有治疗活性药物或药物。 阴道药物递送系统的一个新颖方面是内部水溶性相包含酸性缓冲相。
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公开(公告)号：US08057433B2
公开(公告)日：2011-11-15
申请号：US11571863
申请日：2005-07-08
IPC分类号： A61M1/00
CPC分类号： A61M31/00
摘要： A pharmaceutical delivery system that releases an active agent in a controlled manner for an extended period in the vaginal cavity to treat or cure ailments associated with the vaginal cavity or proximal areas. The delivery system includes an applicator which is composed of a high internal phase emulsion, allowing the delivery system to adhere to the mueosal surfaces of the body, primarily the lining of vaginal cavity. The delivery system can maintain the high internal phase emulsion at a temperature of 86° F. for at least one month, without decomposition or instability of the emulsion.
摘要翻译： 药物递送系统，其以阴道腔中的受控方式长时间释放活性剂以治疗或治愈与阴道腔或近端区域相关的疾病。 递送系统包括由高内相乳液组成的施用器，允许递送系统粘附到身体的月球表面，主要是阴道腔的衬里。 输送系统可以将高内相乳液保持在86°F的温度下至少一个月，而不会使乳液分解或不稳定。
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公开(公告)号：US20110276030A9
公开(公告)日：2011-11-10
申请号：US11571863
申请日：2005-07-08
IPC分类号： A61M31/00
CPC分类号： A61M31/00
摘要： A pharmaceutical delivery system that releases an active agent in a controlled manner for an extended period in the vaginal cavity to treat or cure ailments associated with the vaginal cavity or proximal areas. The delivery system includes an applicator which is composed of a high internal phase emulsion, allowing the delivery system to adhere to the mueosal surfaces of the body, primarily the lining of vaginal cavity. The delivery system can maintain the high internal phase emulsion at a temperature of 86° F. for at least one month, without decomposition or instability of the emulsion.
摘要翻译： 药物递送系统，其以阴道腔中的受控方式长时间释放活性剂以治疗或治愈与阴道腔或近端区域相关的疾病。 递送系统包括由高内相乳液组成的施用器，允许递送系统粘附到身体的月球表面，主要是阴道腔的衬里。 输送系统可以将高内相乳液保持在86°F的温度下至少一个月，而不会使乳液分解或不稳定。
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公开(公告)号：US20080097388A1
公开(公告)日：2008-04-24
申请号：US11571863
申请日：2005-07-08
IPC分类号： A61M31/00
CPC分类号： A61M31/00
摘要： A pharmaceutical delivery system that releases an active agent in a controlled manner for an extended period in the vaginal cavity to treat or cure ailments associated with the vaginal cavity or proximal areas. The delivery system includes an applicator which is composed of a high internal phase emulsion, allowing the delivery system to adhere to the mueosal surfaces of the body, primarily the lining of vaginal cavity. The delivery system can maintain the high internal phase emulsion at a temperature of 86° F. for at least one month, without decomposition or instability of the emulsion.
摘要翻译： 药物递送系统，其以阴道腔中的受控方式长时间释放活性剂以治疗或治愈与阴道腔或近端区域相关的疾病。 递送系统包括由高内相乳液组成的施用器，允许递送系统粘附到身体的月球表面，主要是阴道腔的衬里。 输送系统可以将高内相乳液保持在86°F的温度下至少一个月，而不会使乳液分解或不稳定。
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公开(公告)号：US4454405A
公开(公告)日：1984-06-12
申请号：US415400
申请日：1982-09-07
申请人： Thomas C. Riley
发明人： Thomas C. Riley
摘要： In a welding procedure for joining of adjacent, possibly partially enclosed metal components, such as pipe sections, wherein the welding procedure can be of a gas tungsten arc type such as a heli-arc type, or similar process, and wherein oxidation of metal frequently occurs within the components at the joinder point due to presence of oxygen in the region of weld during the welding procedure; introducing under pressure and at least initially pressure blowing, at a relatively high pressure, an inert gas into the interior of the components in a substantial swirling and interior surface wiping motion. The inert gas is blown through the components, from the entry end, beyond the weld region to rapidly, and substantially completely remove from the interior and weld region, any oxygen or other possible deleterious gas or material. Subsequently a lower pressure introduction of gas will serve to maintain the interior free of oxygen and the like. This procedure permits a clean, rapid welding of the elements in the absence of a build-up of undesired metal at the weld or juncture point, or undesired disturbance of the weld puddle which could cause defects in the weld.
摘要翻译： 在用于接合相邻的，可能部分封闭的金属部件（例如管段）的焊接过程中，其中焊接过程可以是气体钨弧型，例如直角弧型或类似工艺，并且其中金属经常地氧化 由于在焊接过程中在焊接区域中存在氧，所以在接合点处的部件内发生; 在相当高的压力下，在压力下和至少初始压力下将惰性气体以大量的旋转和内表面擦拭运动的形式引入到部件的内部。 惰性气体通过部件从入口端吹出超过焊接区域，并快速地从内部和焊接区域中完全去除任何氧气或其它可能的有害气体或材料。 随后，较低压力的气体引入将用于保持内部不含氧等。 该过程允许在焊缝或接合点处不存在不期望的金属堆积的情况下元件的清洁，快速焊接，或焊接熔池的不期望的干扰，这可能导致焊缝中的缺陷。
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10.发明申请公开(公告)号：US20130115285A1
公开(公告)日：2013-05-09
申请号：US13578289
申请日：2011-02-12
CPC分类号： A61K47/36 , A23L29/256 , A23L29/275 , A23P20/105 , A23V2002/00 , A61K47/34 , A23V2200/22 , A23V2250/5026
摘要： An enteric coating composition including about 0.01% to about 10% resin and about 0.01% to about 10% polymer. The enteric coating composition may be applied to a substrate, such as a pharmaceutical, nutraceutical, fruit, vegetable, agricultural product, or industrial product, to form an enteric coating on the substrate. Also provided is a multiple-component system having a first component including a resin and a second component including a polymer, wherein mixing the first component and the second component forms an enteric coating composition having about 0.01% to about 10% resin and about 0.01% to about 10% polymer. Methods for coating a substrate with the enteric coating compositions are also provided.
摘要翻译： 包括约0.01％至约10％的树脂和约0.01％至约10％的聚合物的肠溶包衣组合物。 肠溶剂组合物可以施用于基质如药物，保健品，水果，蔬菜，农产品或工业产品，以在基材上形成肠溶衣。 还提供了具有包括树脂的第一组分和包含聚合物的第二组分的多组分体系，其中混合第一组分和第二组分形成具有约0.01％至约10％树脂和约0.01％ 至约10％的聚合物。 还提供了用肠溶衣组合物涂覆底物的方法。
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