-
公开(公告)号：US08758623B1
公开(公告)日：2014-06-24
申请号：US13368197
申请日：2012-02-07
Applicant: David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
Inventor： David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
CPC classification number: C12Q1/24 , C12Q1/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.
Abstract translation: 快速单程液体过滤系统有效地将悬浮在液体中的生物颗粒从稀释的进料悬浮液中浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 可以以“级联”方式添加额外的浓缩级，以便使浓缩样品悬浮液中残留在分离的流体中的每个先前阶段的尺寸切割下方的颗粒浓缩。 该方法也可以用于产生在窄范围内浓缩特定靶尺寸颗粒的“带通”浓度。
-
公开(公告)号：US08677840B2
公开(公告)日：2014-03-25
申请号：US12814993
申请日：2010-06-14
Applicant: Andrew Edward Page , David Scott Alburty , Zachary A. Packingham , Pamela S. Murowchick , Alec D. Adolphson
Inventor： Andrew Edward Page , David Scott Alburty , Zachary A. Packingham , Pamela S. Murowchick , Alec D. Adolphson
IPC: G01N1/00
CPC classification number: G01N1/02 , G01N2001/028 , G01N2001/1445
Abstract: Novel rapid, efficient sample collection systems, devices and methods are disclosed which remove and capture particles, and especially potential bioterrorism particles from surfaces into a liquid sample. The devices were developed primarily for obtaining samples of biological contamination from environmental surfaces. Biological particles, as described here, include bacteria, viruses, and other microorganisms, and other particles of biological origin including nucleic acids, proteins, and toxins.
Abstract translation: 公开了新颖的快速，有效的样品收集系统，装置和方法，其将颗粒，特别是潜在的生物恐怖性颗粒从表面去除和捕获到液体样品中。 这些装置主要用于从环境表面获得生物污染的样品。 如本文所述的生物颗粒包括细菌，病毒和其它微生物以及生物来源的其它颗粒，包括核酸，蛋白质和毒素。
-
3.发明授权Liquid to liquid biological particle concentrator with disposable fluid path 有权液体与液体生物颗粒浓缩器与一次性流体路径公开(公告)号：US08584535B2
公开(公告)日：2013-11-19
申请号：US12882188
申请日：2010-09-14
Applicant: Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/4077 , B01L3/0275 , B01L2200/026 , B01L2200/0631 , B01L2300/0681 , B01L2300/161 , C12Q1/24 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
Abstract translation: 公开了高效和快速的基于过滤的浓缩装置，系统和方法，其具有样品流体管线和封装在一次性尖端中的过滤器，其将从液体悬浮的稀释进料悬浮液中的生物颗粒进行浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 然后将浓缩物从一次性尖端中以一定体积的洗脱液分配。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 将一次性尖端附接到仪器的所有导管组合成尖端上端的单个连接点。
-
公开(公告)号：USD731634S1
公开(公告)日：2015-06-09
申请号：US29441099
申请日：2012-12-31
Applicant: Andrew E Page , Zachary A Packingham , David S Alburty , Pamela S Murowchick , Alec D Adolphson
Designer： Andrew E Page , Zachary A Packingham , David S Alburty , Pamela S Murowchick , Alec D Adolphson
-
公开(公告)号：US08726744B2
公开(公告)日：2014-05-20
申请号：US13028897
申请日：2011-02-16
Applicant: David Scott Alburty , Andrew Edward Page , Alec D. Adolphson , Zachary A. Packingham
Inventor： David Scott Alburty , Andrew Edward Page , Alec D. Adolphson , Zachary A. Packingham
CPC classification number: G01N1/4055 , G01N2001/4088
Abstract: The present disclosure provides devices, systems and methods for concentrating a fluid sample. A portable or hand-held concentrator is used to draw the fluid sample through a filter into an internal chamber, capturing target particles on the filter. An elution cartridge containing an elution fluid is used to recover the captured particles into a reduced fluid volume. The hand-held concentrator includes a tip, which, when opened, allows the hand-held concentrator to draw the fluid sample into the tip and through the filter wall into the internal chamber. The drawing occurs due to a vacuum or wicking source in the internal chamber of the hand-held concentrator. The target particles are captured on the filter. The elution fluid contains a foaming agent and is held under a head pressure of gas soluble in the elution fluid. The target particles are eluted from the filter into the reduced fluid volume using an elution foam that is formed when the elution fluid is released from the elution cartridge. Embodiments of the hand-held concentrator are entirely self-contained and can operate without electrical power.
Abstract translation: 本公开提供用于浓缩流体样品的装置，系统和方法。 使用便携式或手持式浓缩器将流体样品通过过滤器吸入内部室中，捕获过滤器上的目标颗粒。 使用含有洗脱液的洗脱柱将捕获的颗粒还原成减少的流体体积。 手持式集中器包括一个尖端，当打开时，该端头允许手持式集中器将流体样品吸入顶端并通过过滤器壁进入内部室。 由于在手持式集中器的内部腔室中有真空或芯吸源，因此出现了这种情况。 目标颗粒被捕获在过滤器上。 洗脱液含有发泡剂，并保持在可溶于洗脱液的气体的头部压力下。 使用在洗脱液体从洗脱药筒释放洗脱液时形成的洗脱泡沫，将目标颗粒从过滤器洗脱成减少的流体体积。 手持式集中器的实施例是完全独立的并且可以在没有电力的情况下工作。
-
Patent Agency Ranking
公开(公告)号：US20100313686A1
公开(公告)日：2010-12-16
申请号：US12814993
申请日：2010-06-14
Applicant: Andrew Edward Page , David Scott Alburty , Zachary A. Packingham , Pamela S. Murowchick , Alec D. Adolphson
Inventor： Andrew Edward Page , David Scott Alburty , Zachary A. Packingham , Pamela S. Murowchick , Alec D. Adolphson
IPC: G01N1/22
CPC classification number: G01N1/02 , G01N2001/028 , G01N2001/1445
Abstract: Novel rapid, efficient sample collection systems, devices and methods are disclosed which remove and capture particles, and especially potential bioterrorism particles from surfaces into a liquid sample. The devices were developed primarily for obtaining samples of biological contamination from environmental surfaces. Biological particles, as described here, include bacteria, viruses, and other microorganisms, and other particles of biological origin including nucleic acids, proteins, and toxins.
Abstract translation: 公开了新颖的快速，有效的样品收集系统，装置和方法，其将颗粒，特别是潜在的生物恐怖性颗粒从表面去除和捕获到液体样品中。 这些装置主要用于从环境表面获得生物污染的样品。 如本文所述的生物颗粒包括细菌，病毒和其它微生物以及生物来源的其它颗粒，包括核酸，蛋白质和毒素。
-
公开(公告)号：US20090101575A1
公开(公告)日：2009-04-23
申请号：US12131015
申请日：2008-05-30
Applicant: David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
Inventor： David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
CPC classification number: C12Q1/24 , C12Q1/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.
Abstract translation: 快速单程液体过滤系统有效地将悬浮在液体中的生物颗粒从稀释的进料悬浮液中浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 可以以“级联”方式添加额外的浓缩级，以便使浓缩样品悬浮液中残留在分离的流体中的每个先前阶段的尺寸切割下方的颗粒浓缩。 该方法也可以用于产生在窄范围内浓缩特定靶尺寸颗粒的“带通”浓度。
-
公开(公告)号：US08677839B2
公开(公告)日：2014-03-25
申请号：US12814972
申请日：2010-06-14
Applicant: Andrew Edward Page , David Scott Alburty , Zachary A. Packingham , Pamela S. Murowchick , Alec D. Adolphson
Inventor： Andrew Edward Page , David Scott Alburty , Zachary A. Packingham , Pamela S. Murowchick , Alec D. Adolphson
IPC: G01N1/00
CPC classification number: G01N1/02 , G01N2001/028 , G01N2001/1445
Abstract: Novel rapid, efficient sample collection systems, devices and methods are disclosed which remove and capture particles, and especially biological particles from surfaces into a liquid sample. The devices were developed primarily for obtaining samples of biological contamination from environmental surfaces. Biological particles, as described here, include bacteria, viruses, and other microorganisms, and other particles of biological origin including nucleic acids, proteins, and toxins.
Abstract translation: 公开了新颖的快速，有效的样品收集系统，装置和方法，其将颗粒，特别是生物颗粒从表面去除和捕获到液体样品中。 这些装置主要用于从环境表面获得生物污染的样品。 如本文所述的生物颗粒包括细菌，病毒和其它微生物以及生物来源的其它颗粒，包括核酸，蛋白质和毒素。
-
公开(公告)号：US08110112B2
公开(公告)日：2012-02-07
申请号：US12131015
申请日：2008-05-30
Applicant: David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
Inventor： David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
CPC classification number: C12Q1/24 , C12Q1/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.
Abstract translation: 快速单程液体过滤系统有效地将悬浮在液体中的生物颗粒从稀释的进料悬浮液中浓缩。 保留样品浓缩物或滞留物悬浮液，同时在单独的流动流中除去分离的流体。 悬浮的生物颗粒包括尺寸范围为约0.001微米至20微米直径的蛋白质/毒素，病毒，DNA和/或细菌等材料。 这些颗粒的浓度对于在稀释悬浮液中检测目标颗粒是有利的，因为将它们浓缩成小体积使得它们更易于检测。 可以以“级联”方式添加额外的浓缩级，以便使浓缩样品悬浮液中残留在分离的流体中的每个先前阶段的尺寸切割下方的颗粒浓缩。 该方法也可以用于产生在窄范围内浓缩特定靶尺寸颗粒的“带通”浓度。
-
10.发明申请公开(公告)号：US20110067505A1
公开(公告)日：2011-03-24
申请号：US12883137
申请日：2010-09-15
Applicant: Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/0067 , B01D46/543 , G01N1/2205 , G01N1/2273 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
Abstract translation: 公开了涉及使用湿泡沫洗脱法从扁平过滤器去除颗粒的装置，系统和方法。 颗粒从大气中捕获到扁平过滤器上。 然后将扁平过滤器放入提取器中，该提取器将湿泡沫流通过扁平过滤器。 泡沫的膨胀用于有效去除捕获的颗粒。 泡沫从捕获的颗粒与过滤器一起流入样品容器。 一旦在样品容器中，泡沫快速分解，留下分析就绪的液体样品。
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.013 seconds)
