公开(公告)号：US20160280704A1

公开(公告)日：2016-09-29

申请号：US14778019

申请日：2014-03-19

申请人： Matthew Lloyd Childers ,  Christopher Dinsmore ,  Peter Fuller ,  David Guerin ,  Jason David Katz ,  Qinglin Pu ,  Mark E. Scott ,  Christopher F. Thompson ,  Hongjun Zhang ,  Danielle Falcone ,  Luis Torres ,  Jason Brubaker ,  Hongbo Zeng ,  Jiaqiang Cai ,  Xiaoxing Du ,  Chonggang Wang ,  Yunfeng Bai ,  Norman Kong ,  Yumei Liu ,  Zhixiang Zheng ,  Merck Sharp & Dohme Corp.

发明人： Matthew Lloyd Childers ,  Christopher Dinsmore ,  Peter Fuller ,  David Guerin ,  Jason David Katz ,  Qinglin Pu ,  Mark E. Scott ,  Christopher F. Thompson ,  Hongjun Zhang ,  Danielle Falcone ,  Luis Torres ,  Jason Brubaker ,  Hongbo Zeng ,  Jiaqiang Cai ,  Xiaoxing Du ,  Chonggang Wang ,  Yunfeng Bai ,  Norman Kong ,  Yumei Liu ,  Zhixiang Zheng

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

公开(公告)号：US20170240567A1

公开(公告)日：2017-08-24

申请号：US15519740

申请日：2015-10-21

申请人： Mark E. Scott ,  David Guerin ,  Danielle Molinari ,  Sam Kattar ,  Peter Fuller ,  Christopher Dinsmore ,  Normon Kong ,  Yunfeng Bai ,  Jianmin FU ,  Yumei Liu ,  Zhixiang Zheng

发明人： Mark E. Scott ,  David Guerin ,  Danielle Molinari ,  Sam Kattar ,  Peter Fuller ,  Christopher Dinsmore ,  Normon Kong ,  Yunfeng Bai ,  Jianmin FU ,  Yumei Liu ,  Zhixiang Zheng

IPC分类号： C07D519/00 ,  A61K31/4545 ,  A61K31/55 ,  A61K31/538 ,  A61K31/541 ,  A61K31/554 ,  A61K31/553 ,  C07D471/04 ,  A61K31/5377

CPC分类号： C07D519/00 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61P11/06 ,  A61P19/02 ,  A61P35/00 ,  C07D471/04

摘要： The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.

公开(公告)号：US20160272633A1

公开(公告)日：2016-09-22

申请号：US14778052

申请日：2014-03-19

申请人： Christopher DINSMORE ,  Peter FULLER ,  David GUERIN ,  Christopher F. THOMPSON ,  Qinglin PU ,  Mark E. SCOTT ,  Jason David KATZ ,  Ravi KURUKLASURIYA ,  Joshua T. CLOSE ,  Danielle FALCONE ,  Jason BRUDAKER ,  Hongbo ZENG ,  Yunfeng BAI ,  Jianmin FU ,  Norman KONG ,  Yumei LIU ,  Zhixiang ZHENG ,  MERCK SHARP & DOHME CORP.

发明人： Christopher Dinsmore ,  Peter Fuller ,  David Guerin ,  Christopher F. Thompson ,  Qinglin Pu ,  Mark E. Scott ,  Jason David Katz ,  Ravi Kuruklasuriya ,  Joshua T. Close ,  Danielle Falcone ,  Jason Brubaker ,  Hongbo Zeng ,  Yunfeng Bai ,  Jianmin Fu ,  Norman Kong ,  Yumei Liu ,  Zhixiang Zheng

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

公开(公告)号：US20160272634A1

公开(公告)日：2016-09-22

申请号：US14778055

申请日：2014-03-19

申请人： Christopher DINSMORE ,  Peter FULLER ,  David GUERIN ,  Jason David KATZ ,  Christopher F. THOMPSON ,  Danielle FALCONE ,  Wei DENG ,  Luis TORRES ,  Hongbo ZENG ,  Yunfeng BAI ,  Jianmin FU ,  Norman KONG ,  Yumei LIU ,  Zhixiang ZHENG ,  Mark E. SCOTT ,  MERCK SHARP & DOHME CORP.

发明人： Christopher Dinsmore ,  Peter Fuller ,  David Guerin ,  Jason David Katz ,  Christopher F. Thompson ,  Danielle Falcone ,  Wei Deng ,  Luis Torres ,  Hongbo Zeng ,  Yunfeng Bai ,  Jianmin Fu ,  Norman Kong ,  Yumei Liu ,  Zhixiang Zheng ,  Mark E. Scott

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D519/00

摘要： The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

摘要翻译： 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。