摘要:
The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要:
The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.
摘要:
The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要:
The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.
摘要:
The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
摘要:
Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
摘要:
The present invention relates to pyridazin-4(1H)-one derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要:
The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer. The present invention provides novel compounds which are inhibitors of JAKs. The invention also provides a method for the treatment and prevention of JAK-mediated diseases and disorders using the novel compounds, as well as pharmaceutical compositions containing the compounds.