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公开(公告)号：US07166449B2
公开(公告)日：2007-01-23
申请号：US10120319
申请日：2002-04-09
申请人： Diane E. Taylor , Zhongming Ge
发明人： Diane E. Taylor , Zhongming Ge
CPC分类号： C12N9/1051 , C07K2319/00 , C12Q1/6886
摘要： A bacterial α1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohy-drate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.
摘要翻译： 提供细菌α1,3-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,3-岩藻糖基转移酶多肽及其活性片段，其可用于生产低聚糖例如Lewis X，Lewis Y和siayl Lewis X，其结构上类似于某些肿瘤相关性碳水化合物 在哺乳动物中发现的抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。 此外，本发明的多肽可用于开发诊断和研究测定以确定幽门螺杆菌在人标本中的存在。
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公开(公告)号：US07029891B2
公开(公告)日：2006-04-18
申请号：US10392098
申请日：2003-03-17
申请人： Diane E. Taylor , Zhongming Ge
发明人： Diane E. Taylor , Zhongming Ge
CPC分类号： C12N9/1051 , C07K2319/00 , C12Q1/6886
摘要： A bacterial α1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.
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3.发明授权α-1,3 fucosyltransferases and expression systems for making and expressing them 失效α-1,3岩藻糖基转移酶和用于制备和表达它们的表达系统公开(公告)号：US06962806B2
公开(公告)日：2005-11-08
申请号：US10189977
申请日：2002-07-03
申请人： Diane E. Taylor , Zhongming Ge
发明人： Diane E. Taylor , Zhongming Ge
CPC分类号： C12N9/1051 , C07K2319/00 , C12Q1/6886
摘要： A bacterial α1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing α1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.
摘要翻译： 提供细菌α1,3-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,3-岩藻糖基转移酶多肽及其活性片段，其可用于生产低聚糖例如Lewis X，Lewis Y和siayl Lewis X，其结构上类似于某些肿瘤相关碳水化合物 在哺乳动物中发现的抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。 此外，本发明的多肽可用于开发诊断和研究测定以确定幽门螺杆菌在人标本中的存在。
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公开(公告)号：US06399337B1
公开(公告)日：2002-06-04
申请号：US09092315
申请日：1998-06-05
申请人： Diane E. Taylor , Zhongming Ge
发明人： Diane E. Taylor , Zhongming Ge
IPC分类号： C12P1918
CPC分类号： C12N9/1051 , C07K2319/00 , C12Q1/6886
摘要： A bacterial &agr;1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing &agr;1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.
摘要翻译： 提供细菌α1,3-岩藻糖基转移酶基因和推导的氨基酸序列。 该基因可用于制备α1,3-岩藻糖基转移酶多肽及其活性片段，其可用于生产低聚糖例如Lewis X，Lewis Y和siayl Lewis X，其结构上类似于某些肿瘤相关碳水化合物 在哺乳动物中发现的抗原。 这些产品糖缀合物在开发检测哺乳动物肿瘤的检测中也具有研究和诊断效用。 此外，本发明的多肽可用于开发诊断和研究测定以确定幽门螺杆菌在人标本中的存在。
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公开(公告)号：US06534298B2
公开(公告)日：2003-03-18
申请号：US09733524
申请日：2000-12-07
申请人： Diane E. Taylor , Zhongming Ge
发明人： Diane E. Taylor , Zhongming Ge
IPC分类号： C12N910
CPC分类号： C12N9/1051 , C07K2319/00 , C12Q1/6886
摘要： A bacterial &agr;1,3-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing &agr;1,3-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, and siayl Lewis X, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors. In addition the polypeptide of the invention can be used to develop diagnostic and research assays to determine the presence of H. pylori in human specimens.
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