-
公开(公告)号：US10745742B2
公开(公告)日：2020-08-18
申请号：US16230936
申请日：2018-12-21
Applicant: 10X GENOMICS, INC.
Inventor： Zachary Bent , Elliott Meer , Daniel Riordan , Paul Ryvkin , Niranjan Srinivas , Jessica Terry
IPC: C12Q1/68 , C40B20/04 , C40B50/16 , C40B50/18 , G06K19/06 , C12Q1/6806 , C12Q1/6811 , C12Q1/6834
Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.
-
公开(公告)号：US20210277444A1
公开(公告)日：2021-09-09
申请号：US17095578
申请日：2020-11-11
Applicant: 10X GENOMICS, INC.
Inventor： Zachary Bent , Elliott Meer , Daniel Riordan , Paul Ryvkin , Niranjan Srinivas , Jessica Terry , Alex Gagnon
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/6834 , C40B20/04 , C40B50/16 , C40B50/18 , G06K19/06
Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.
-
公开(公告)号：US20190249226A1
公开(公告)日：2019-08-15
申请号：US16230936
申请日：2018-12-21
Applicant: 10X GENOMICS, INC.
Inventor： Zachary Bent , Elliott Meer , Daniel Riordan , Paul Ryvkin , Niranjan Srinivas , Jessica Terry , Alex Gagnon
IPC: C12Q1/6806 , G06K19/06 , C12Q1/6811 , C12Q1/6834 , C40B20/04 , C40B50/16 , C40B50/18
Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.
-
Patent Agency Ranking
4.发明申请公开(公告)号：US20210295947A1
公开(公告)日：2021-09-23
申请号：US17098139
申请日：2020-11-13
Applicant: 10X Genomics, Inc.
Inventor： Sofia Kyriazopoulou-Panagiotopoulou , Patrick Marks , Michael Schnall-Levin , Xinying Zheng , Mirna Jarosz , Serge Saxonov , Kristina Giorda , Patrice Mudivarti , Heather Ordonez , Jessica Terry , William Haynes Heaton
Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.
-
5.发明申请SYSTEMS AND METHODS FOR DETERMINING STRUCTURAL VARIATION AND PHASING USING VARIANT CALL DATA 审中-公开使用变量呼叫数据确定结构变化和相位的系统和方法公开(公告)号：US20160232291A1
公开(公告)日：2016-08-11
申请号：US15019928
申请日：2016-02-09
Applicant: 10X Genomics, Inc.
Inventor： Sofia Kyriazopoulou-Panagiotopoulou , Patrick Marks , Michael Schnall-Levin , Xinying Zheng , Mirna Jarosz , Serge Saxonov , Kristina Giorda , Patrice Mudivarti , Heather Ordonez , Jessica Terry , William Haynes Heaton
IPC: G06F19/22
Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.
Abstract translation: 提供了使用从生物样品的核酸获得的变体调用数据来确定结构变化和定相的系统和方法。 获得序列读数，每个包含对应于测试核酸的子集的部分和编码独立于测序数据的条形码的部分。 获取Bin信息。 每个箱表示样品核酸的不同部分。 每个箱对应于从序列读取形成的多组序列读取中的一组序列读取，使得在相应的序列读取集合中读取的每个序列对应于由对应于相应的存储体的bin所代表的核酸的子集 组。 二项式测试识别具有更多序列读取的bin对，其中相同的条形码与预期的机会相同。 概率模型根据这些箱对的序列读数确定结构变异似然。
-
公开(公告)号：US11884962B2
公开(公告)日：2024-01-30
申请号：US17095578
申请日：2020-11-11
Applicant: 10X GENOMICS, INC.
Inventor： Zachary Bent , Elliott Meer , Daniel Riordan , Paul Ryvkin , Niranjan Srinivas , Jessica Terry , Alex Gagnon
IPC: C12Q1/6806 , C12Q1/6811 , C12Q1/6834 , C40B20/04 , C40B50/16 , C40B50/18 , G06K19/06
CPC classification number: C12Q1/6806 , C12Q1/6811 , C12Q1/6834 , C40B20/04 , C40B50/16 , C40B50/18 , G06K19/06093 , C12Q1/6806 , C12Q2521/319 , C12Q2521/501 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/537 , C12Q2565/629
Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.
-
7.发明授权公开(公告)号：US10854315B2
公开(公告)日：2020-12-01
申请号：US15019928
申请日：2016-02-09
Applicant: 10X Genomics, Inc.
Inventor： Sofia Kyriazopoulou-Panagiotopoulou , Patrick Marks , Michael Schnall-Levin , Xinying Zheng , Mirna Jarosz , Serge Saxonov , Kristina Giorda , Patrice Mudivarti , Heather Ordonez , Jessica Terry , William Haynes Heaton
Abstract: Systems and methods for determining structural variation and phasing using variant call data obtained from nucleic acid of a biological sample are provided. Sequence reads are obtained, each comprising a portion corresponding to a subset of the test nucleic acid and a portion encoding a barcode independent of the sequencing data. Bin information is obtained. Each bin represents a different portion of the sample nucleic acid. Each bin corresponds to a set of sequence reads in a plurality of sets of sequence reads formed from the sequence reads such that each sequence read in a respective set of sequence reads corresponds to a subset of the nucleic acid represented by the bin corresponding to the respective set. Binomial tests identify bin pairs having more sequence reads with the same barcode in common than expected by chance. Probabilistic models determine structural variation likelihood from the sequence reads of these bin pairs.
-
公开(公告)号：US20200063191A1
公开(公告)日：2020-02-27
申请号：US16680343
申请日：2019-11-11
Applicant: 10X GENOMICS, INC.
Inventor： Zachary Bent , Elliott Meer , Daniel Riordan , Paul Ryvkin , Niranjan Srinivas , Jessica Terry , Alex Gagnon
IPC: C12Q1/6806 , G06K19/06 , C40B50/18 , C40B50/16 , C40B20/04 , C12Q1/6834 , C12Q1/6811
Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.017 seconds)
