公开(公告)号：US20240150745A1

公开(公告)日：2024-05-09

申请号：US18481673

申请日：2023-10-05

Applicant: 10x Genomics, Inc.

Inventor： Shankar SHASTRY ,  Javelin C. CHI ,  Paul Eugene LUND

IPC: C12N9/00 ,  C07K14/245 ,  C12Q1/6827

CPC classification number: C12N9/93 ,  C07K14/245 ,  C12Q1/6827 ,  C07K2319/21 ,  C07K2319/60 ,  C07K2319/80

Abstract: A recombinant ligase composition including a recombinantly-produced ligase isolated from Acanthocystis turfacea chlorella virus 1 (ATCV-1) fused to at least one polynucleotide-binding polypeptide is provided. Compositions containing the recombinant ligase composition, vectors encoding the recombinant ligase composition, and methods of making and using the recombinant ligase composition are also provided.