公开(公告)号：US11779654B2

公开(公告)日：2023-10-10

申请号：US16753117

申请日：2018-10-04

Applicant: 2seventy bio, Inc.

Inventor： Jordan Jarjour ,  Kyle Havens ,  Michael Certo ,  Max Echterling

IPC: A61K48/00 ,  A61P3/06 ,  C12N9/22 ,  C12N9/64 ,  C12N15/63 ,  C12N15/90

CPC classification number: A61K48/005 ,  A61K48/0041 ,  A61P3/06 ,  C12N9/22 ,  C12N9/6454 ,  C12N15/63 ,  C12N15/90 ,  C12Y304/21061

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of hypercholesterolemia or a condition associated therewith.

公开(公告)号：US11530395B2

公开(公告)日：2022-12-20

申请号：US16341228

申请日：2017-10-17

Applicant: 2seventy bio, Inc.

Inventor： Jordan Jarjour ,  Kyle Havens

IPC: C12N9/22 ,  C12N15/10 ,  C12N15/87 ,  C07K14/71

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a TGFβR2 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

公开(公告)号：US11732255B2

公开(公告)日：2023-08-22

申请号：US17150293

申请日：2021-01-15

Applicant: 2seventy bio, Inc.

Inventor： Jordan Jarjour ,  Kyle Havens ,  Anne-Rachel Krostag

IPC: C12N9/22 ,  C12N15/10 ,  C12N15/90 ,  C12N5/0783 ,  C12N9/10 ,  A61P35/00 ,  A61K35/17 ,  C07K16/28

CPC classification number: C12N15/102 ,  A61K35/17 ,  A61P35/00 ,  C07K16/2863 ,  C12N5/0636 ,  C12N5/0646 ,  C12N9/10 ,  C12N9/22 ,  C12N15/907 ,  C07K2319/80 ,  C07K2319/81 ,  C12N2510/00 ,  C12N2800/80

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.