公开(公告)号：US20200033344A1

公开(公告)日：2020-01-30

申请号：US16539742

申请日：2019-08-13

申请人： ABBOTT LABORATORIES ,  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis ,  Andrea Branch ,  Francis Eng

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of HCV core protein and the DNA binding domain antibody or antibody fragment recognizes an epitope in amino acids 95-123 (e.g., in amino acids 99-117) of HCV core protein.

公开(公告)号：US10444242B2

公开(公告)日：2019-10-15

申请号：US15189646

申请日：2016-06-22

申请人： ABBOTT LABORATORIES ,  Icahn School of Medicine at Mount Sinai

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis ,  Andrea Branch ,  Francis Eng

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of HCV core protein and the DNA binding domain antibody or antibody fragment recognizes an epitope in amino acids 95-123 (e.g., in amino acids 99-117) of HCV core protein.

公开(公告)号：US09371374B2

公开(公告)日：2016-06-21

申请号：US14138991

申请日：2013-12-23

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/569 ,  C07K16/10 ,  G01N33/576

CPC分类号： G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

摘要： The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection.

摘要翻译： 本发明涉及用于检测HCV抗原的单克隆抗体。 更具体地，本发明描述了用于检测HCV感染的抗HCV核心抗原脂质结合结构域和免疫测定方法，试剂盒和组合物的抗体。

公开(公告)号：US10345311B2

公开(公告)日：2019-07-09

申请号：US15189638

申请日：2016-06-22

申请人： ABBOTT LABORATORIES

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： A61K39/00 ,  G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.

公开(公告)号：US20140272931A1

公开(公告)日：2014-09-18

申请号：US14138991

申请日：2013-12-23

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/569 ,  C07K16/10

CPC分类号： G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

摘要： The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection.

摘要翻译： 本发明涉及用于检测HCV抗原的单克隆抗体。 更具体地，本发明描述了用于检测HCV感染的抗HCV核心抗原脂质结合结构域和免疫测定方法，试剂盒和组合物的抗体。

公开(公告)号：US11428694B2

公开(公告)日：2022-08-30

申请号：US17231782

申请日：2021-04-15

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/576 ,  C07K16/00 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.

公开(公告)号：US20210231665A1

公开(公告)日：2021-07-29

申请号：US17231782

申请日：2021-04-15

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.

公开(公告)号：US10197573B2

公开(公告)日：2019-02-05

申请号：US15079013

申请日：2016-03-23

申请人： ABBOTT LABORATORIES

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection.

公开(公告)号：US20160291020A1

公开(公告)日：2016-10-06

申请号：US15079013

申请日：2016-03-23

申请人： ABBOTT LABORATORIES

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/576 ,  C07K16/10

CPC分类号： G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

摘要： The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection.

摘要翻译： 本发明涉及用于检测HCV抗原的单克隆抗体。 更具体地，本发明描述了用于检测HCV感染的抗HCV核心抗原脂质结合结构域和免疫测定方法，试剂盒和组合物的抗体。