公开(公告)号：US09841427B2

公开(公告)日：2017-12-12

申请号：US14851471

申请日：2015-09-11

申请人： Abbott Laboratories

发明人： George J. Dawson ,  Suresh M. Desai ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  John Prostko ,  M. Felicia Bogdan ,  Christopher C. Marohnic

IPC分类号： G01N33/53 ,  G01N33/576 ,  G01N33/543 ,  G01N33/569

CPC分类号： G01N33/5767 ,  G01N33/5306 ,  G01N33/54306 ,  G01N33/56983 ,  G01N2333/186 ,  G01N2333/914 ,  G01N2469/10 ,  G01N2469/20

摘要： The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample.

公开(公告)号：US09371374B2

公开(公告)日：2016-06-21

申请号：US14138991

申请日：2013-12-23

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/569 ,  C07K16/10 ,  G01N33/576

CPC分类号： G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

摘要： The present invention relates to monoclonal antibodies for the detection of HCV antigen. More specifically, the invention describes antibodies against HCV core antigen lipid binding domain and immunoassay methods, kits and compositions for use in detecting HCV infection.

摘要翻译： 本发明涉及用于检测HCV抗原的单克隆抗体。 更具体地，本发明描述了用于检测HCV感染的抗HCV核心抗原脂质结合结构域和免疫测定方法，试剂盒和组合物的抗体。

公开(公告)号：US09194873B2

公开(公告)日：2015-11-24

申请号：US14139108

申请日：2013-12-23

申请人： Abbott Laboratories

发明人： George J. Dawson ,  Suresh M. Desai ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  John Prostko

IPC分类号： G01N33/576 ,  G01N33/543

CPC分类号： G01N33/5767 ,  G01N33/5306 ,  G01N33/54306 ,  G01N33/56983 ,  G01N2333/186 ,  G01N2333/914 ,  G01N2469/10 ,  G01N2469/20

摘要： The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample.

摘要翻译： 本发明一般涉及用于在测试样品中同时检测HCV抗原和抗HCV抗体的组合免疫测定，试剂和试剂盒。

公开(公告)号：US11428694B2

公开(公告)日：2022-08-30

申请号：US17231782

申请日：2021-04-15

申请人： Abbott Laboratories

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： G01N33/576 ,  C07K16/00 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.

公开(公告)号：US20200033344A1

公开(公告)日：2020-01-30

申请号：US16539742

申请日：2019-08-13

申请人： ABBOTT LABORATORIES ,  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis ,  Andrea Branch ,  Francis Eng

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of HCV core protein and the DNA binding domain antibody or antibody fragment recognizes an epitope in amino acids 95-123 (e.g., in amino acids 99-117) of HCV core protein.

公开(公告)号：US10444242B2

公开(公告)日：2019-10-15

申请号：US15189646

申请日：2016-06-22

申请人： ABBOTT LABORATORIES ,  Icahn School of Medicine at Mount Sinai

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis ,  Andrea Branch ,  Francis Eng

IPC分类号： G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of HCV core protein and the DNA binding domain antibody or antibody fragment recognizes an epitope in amino acids 95-123 (e.g., in amino acids 99-117) of HCV core protein.

公开(公告)号：US10345311B2

公开(公告)日：2019-07-09

申请号：US15189638

申请日：2016-06-22

申请人： ABBOTT LABORATORIES

发明人： Robert Ziemann ,  April Ahlberg ,  David Hawksworth ,  Bryan Tieman ,  A. Scott Muerhoff ,  Christopher Marohnic ,  Kathy Otis

IPC分类号： A61K39/00 ,  G01N33/576 ,  C07K16/10

摘要： The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.

公开(公告)号：US09790478B2

公开(公告)日：2017-10-17

申请号：US14139053

申请日：2013-12-23

申请人： Abbott Laboratories

发明人： A. Scott Muerhoff ,  Christopher Marohnic ,  Larry Birkenmeyer ,  John Prostko ,  M. Felisha Bogdan ,  Robin Gutierrez

IPC分类号： G01N33/569 ,  C12N9/14 ,  G01N33/576 ,  C07K14/005

CPC分类号： C12N9/14 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/21 ,  C12N2770/24222 ,  C12N2800/22 ,  G01N33/5767 ,  G01N2469/20

摘要： The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies.

公开(公告)号：US20170003290A9

公开(公告)日：2017-01-05

申请号：US14851471

申请日：2015-09-11

申请人： Abbott Laboratories

发明人： GEORGE J. DAWSON ,  Suresh M. Desai ,  Robin A. Gutierrez ,  A. Scott Muerhoff ,  John Prostko ,  M. Felicia Bogdan ,  Christopher C. Marohnic

IPC分类号： G01N33/576

CPC分类号： G01N33/5767 ,  G01N33/5306 ,  G01N33/54306 ,  G01N33/56983 ,  G01N2333/186 ,  G01N2333/914 ,  G01N2469/10 ,  G01N2469/20

摘要： The present invention generally relates to combination immunoassays, reagents and kits for simultaneous detection of HCV antigens and anti-HCV antibodies in a test sample.

摘要翻译： 本发明一般涉及用于在测试样品中同时检测HCV抗原和抗HCV抗体的组合免疫测定，试剂和试剂盒。

公开(公告)号：US20230258638A1

公开(公告)日：2023-08-17

申请号：US18045845

申请日：2022-10-12

申请人： Abbott Laboratories

发明人： A. Scott Muerhoff ,  John C. Prostko ,  James L. Stewart ,  Mary A. RODGERS ,  Gavin A. CLOHERTY ,  James Hartnett ,  Jeff Moore ,  Kathy Otis ,  Alak Kar ,  Bailin Tu ,  Bryan Tieman ,  Carolyn Strobel ,  David Hawksworth ,  Robert Ziemann ,  Zhihong Lin ,  Chris Marohnic ,  Peter Wiebe ,  Todd Meyer ,  Weijie Jiao ,  Gangamani S. Beligere ,  Saminathan X. Muthusamy ,  Jessica L. Grieshaber ,  Sandra K. Pearce ,  Edwin C. Frias ,  Russell E. Taylor ,  Kelly Coller ,  Yangrong E. Zhang ,  Thomas T. Biegalski ,  David J. Daghfal ,  Claudio Galli ,  Sergey Y. Tetin ,  Qiaoqiao Ruan ,  Patrick MacDonald ,  Michael S. Cassidy ,  Mary E. Gardiner ,  Mary Ann P. Palafox ,  Matthew S. Matias ,  Melissa B. Brennan ,  Philip W. Schultz ,  Beth C. Trudeau

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/165 ,  G01N2469/20 ,  G01N2800/52

摘要： Disclosed herein are methods, kits, systems, algorithms and improvements for detecting the presence of or determining an amount, quantity, concentration and/or level of an antibody against at least one type of β-coronavirus, such as, for example, an antibody against SARS-CoV or SARS-CoV-2, in one or more samples obtained from a subject. In some aspects, the methods, kits and systems relate to detecting the presence of or determining an amount, quantity, concentration and/or level of at least one type of anti-β-coronavirus antibody, such as an IgG and/or IgM antibody, in one or more samples obtained from a subject. The methods, kits systems, algorithms and improvements can also be used to monitor a subject's response and/or treatment to a β-coronavirus, determine whether or not a subject will develop or experience a cytokine storm, predict outcome in a subject, determine whether a subject can be administered a vaccine for a β-coronavirus, monitoring antibody response in individuals that have received a β-coronavirus vaccine (such as a SARS-CoV-2 vaccine), and/or determine the immune status of a subject.