公开(公告)号：US09994581B2

公开(公告)日：2018-06-12

申请号：US15103215

申请日：2014-12-10

申请人： AbbVie Inc.

发明人： Le Wang ,  Robin R. Frey ,  Todd M. Hansen ,  Dachun Liu ,  William J. McClellan ,  Keith F. McDaniel ,  John K. Pratt ,  Carol K. Wada

IPC分类号： C07D491/22 ,  C07D491/056 ,  A61K45/06 ,  A61K31/4353 ,  C07D491/153

CPC分类号： C07D491/056 ,  A61K31/4353 ,  A61K45/06 ,  C07D491/153 ,  C07D491/22

摘要： The present invention provides for compounds of formula (I) wherein Rx, X, Y, Y1, L1, A1, A2, A3, A4, A5, A6, A7, and A8, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：US20170015673A1

公开(公告)日：2017-01-19

申请号：US15103215

申请日：2014-12-10

申请人： ABBVIE INC.

发明人： Le Wang ,  Robin R. Frey ,  Todd M. Hansen ,  Dachun Liu ,  William J. McClellan ,  Keith F. McDaniel ,  John K. Pratt ,  Carol K. Wada

IPC分类号： C07D491/056 ,  C07D491/153

CPC分类号： C07D491/056 ,  A61K31/4353 ,  A61K45/06 ,  C07D491/153 ,  C07D491/22

摘要： The present invention provides for compounds of formula (I) wherein Rx, X, Y, Y1, L1, A1, A2, A3, A4, A5, A6, A7, and A8, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物，其中Rx，X，Y，Y1，L1，A1，A2，A3，A4，A5，A6，A7和A8具有说明书中定义的任何值， 其药学上可接受的盐，其可用作治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂。 还提供了由一种或多种式（I）化合物组成的药物组合物。

公开(公告)号：US20180296566A1

公开(公告)日：2018-10-18

申请号：US16012379

申请日：2018-06-19

申请人： AbbVie Inc.

发明人： Le Wang ,  John K. Pratt ,  Keith F. McDaniel ,  Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James H. Holms ,  Warren M. Kati ,  Dachun Liu ,  Robert A. Mantei ,  William J. McClellan ,  George S. Sheppard ,  Carol K. Wada

IPC分类号： A61K31/541 ,  A61K45/06 ,  C07D487/04 ,  C07D471/04 ,  A61K31/5025 ,  A61K31/437 ,  A61K31/5377

摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20230158039A1

公开(公告)日：2023-05-25

申请号：US17810313

申请日：2022-06-30

申请人： AbbVie Inc.

发明人： Le Wang ,  John K. Pratt ,  Keith F. McDaniel ,  Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James H. Holms ,  Warren M. Kati ,  Dachun Liu ,  Robert A. Mantei ,  William J. McClellan ,  George S. Sheppard ,  Carol K. Wada

IPC分类号： A61K31/541 ,  C07D487/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06

CPC分类号： A61K31/541 ,  C07D487/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06

摘要： The present invention provides for compounds of formula (I)






wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20140162971A1

公开(公告)日：2014-06-12

申请号：US13828285

申请日：2013-03-14

申请人： ABBVIE INC.

发明人： Le WANG ,  John K PRATT ,  Keith F. McDANIEL ,  Yujia DAI ,  Steven D FIDANZE ,  Lisa HASVOLD ,  John H. Holms ,  Warren M. KATI ,  Dachun LIU ,  Robert A Mantei ,  William J. McCLELLAN ,  George S. SHEPPARD ,  Carol K. Wada

IPC分类号： C07D471/04 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/04 ,  A61K31/5025 ,  A61K31/437 ,  A61K31/541

CPC分类号： A61K31/541 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐 ，其作为治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂是有用的。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：US20210236508A1

公开(公告)日：2021-08-05

申请号：US16996090

申请日：2020-08-18

申请人： AbbVie Inc.

发明人： Le Wang ,  John K. Pratt ,  Keith F. McDaniel ,  Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James H. Holms ,  Warren M. Kati ,  Dachun Liu ,  Robert A. Mantei ,  William J. McClellan ,  George S. Sheppard ,  Carol K. Wada

IPC分类号： A61K31/541 ,  C07D487/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06

摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

公开(公告)号：US20160143916A1

公开(公告)日：2016-05-26

申请号：US15008994

申请日：2016-01-28

申请人： AbbVie Inc.

发明人： Le Wang ,  John K. Pratt ,  Keith F. McDaniel ,  Yujia Dai ,  Steven D. Fidanze ,  Lisa Hasvold ,  James H. Holms ,  Warren M. Kati ,  Dachun Liu ,  Robert A. Mantei ,  William J. McClellan ,  George S. Sheppard ,  Carol K. Wada

IPC分类号： A61K31/541 ,  A61K45/06 ,  A61K31/5025 ,  A61K31/437 ,  A61K31/5377

CPC分类号： A61K31/541 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04

摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐 ，其作为治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂是有用的。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：US20140256705A1

公开(公告)日：2014-09-11

申请号：US14203641

申请日：2014-03-11

申请人： Abbvie Inc.

发明人： Lisa A. Hasvold ,  Dachun Liu ,  Keith F. McDaniel ,  John Pratt ,  George S. Sheppard ,  Carol K. Wada ,  Kevin R. Woller

IPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/519 ,  A61K31/497 ,  C07D487/04 ,  A61K31/501 ,  C07D471/04 ,  A61K31/496

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/463

摘要： The present invention provides for compounds of formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

摘要翻译： 本发明提供式（I）化合物，其中R1，R2，A1，A2，A3，A4，X和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作 治疗疾病和病症，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。