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1.发明公开公开(公告)号：US20240058450A1
公开(公告)日：2024-02-22
申请号：US17804696
申请日：2022-05-31
申请人： AbbVie Inc.
发明人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC分类号： A61K45/06 , C07D417/14 , C07D513/04 , A61K47/68 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/538 , C07D487/04
CPC分类号： A61K45/06 , C07D417/14 , C07D513/04 , A61K47/6889 , A61K47/6803 , A61K47/6849 , C07D487/04 , A61K47/6883 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/538 , A61K47/6851
摘要： The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
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公开(公告)号：US20200002421A1
公开(公告)日：2020-01-02
申请号：US16308622
申请日：2017-06-07
申请人： AbbVie Inc.
发明人： Lorenzo Benatuil , Milan Bruncko , Debra Chao , Kamel Izeradjene , Andrew S. Judd , Andrew C. Phillips , Andrew J. Souers , Archana Thakur , George Doherty , Robin R. Frey , Xiaohong Song , Gerard M. Sullivan , Zhi-Fu Tao
摘要： The invention relates to B7 homology 3 protein (B7-H3) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US20240199745A1
公开(公告)日：2024-06-20
申请号：US18349904
申请日：2023-07-10
申请人： AbbVie Inc.
发明人： Erwin R. Boghaert , Milan Bruncko , George Doherty , Robin R. Frey , Andrew S. Judd , Andrew C. Phillips , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao
CPC分类号： C07K16/2863 , A61K47/65 , A61K47/6803 , A61K47/6845 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6889 , A61P35/00 , A61K2039/505 , A61K2039/545 , A61K45/06 , C07K16/22 , C07K16/2827
摘要： The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.
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公开(公告)号：US20180071262A1
公开(公告)日：2018-03-15
申请号：US15727220
申请日：2017-10-06
申请人： AbbVie Inc.
发明人： Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
IPC分类号： A61K31/4184 , C07D498/10 , C07D403/06 , C07D493/10 , C07D491/107 , C07D263/52 , C07D417/12 , C07D417/04 , C07D413/12 , C07D413/04 , C07D409/12 , C07D407/12 , C07D401/12 , C07D235/02 , C07D413/14 , C07D403/12 , C07D409/06 , C07D405/06 , A61K31/423 , A61K31/4439 , C07D401/06 , C07D495/10
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4439 , C07D235/02 , C07D263/52 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D491/107 , C07D493/10 , C07D495/10 , C07D498/10
摘要： Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1----Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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公开(公告)号：US20200239553A1
公开(公告)日：2020-07-30
申请号：US16675784
申请日：2019-11-06
申请人： AbbVie Inc.
发明人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC分类号： C07K16/18 , C07D417/14 , C07D487/04 , C07D513/04 , A61K47/68
摘要： Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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公开(公告)号：US20200002432A1
公开(公告)日：2020-01-02
申请号：US16308755
申请日：2017-06-08
申请人： AbbVie Inc.
发明人： Lorenzo Benatuil , Milan Bruncko , George Doherty , Robin R. Frey , Andrew S. Judd , Yingchun Li , Andrew Mccluskey , Andrew C. Phillips , Darren C. Phillips , Jane Seagal , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao
摘要： The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US20190153107A1
公开(公告)日：2019-05-23
申请号：US16308557
申请日：2017-06-07
申请人： AbbVie Inc.
发明人： Erwin R. Boghaert , Milan Bruncko , George Doherty , Robin R. Frey , Andrew S. Judd , Andrew C. Phillips , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao
摘要： The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.
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公开(公告)号：US20180193315A1
公开(公告)日：2018-07-12
申请号：US15907597
申请日：2018-02-28
申请人： AbbVie Inc.
发明人： Edward A. Kesicki , Arthur F. Kluge , Michael A. Patane , John H. Van Drie, JR. , Ce Wang , Maricel Torrent , Michael L. Curtin , Todd M. Hansen , Rick F. Clark , Robin R. Frey , Zhiqin Ji , Yujia Dai , William J. McClellan , Jane Gong , Gui-dong G. Zhu , Anthony Mastracchio , Michael R. Michaelides , Thomas D. Penning , Chunqiu C. Lai
IPC分类号： A61K31/4184 , C07D403/06 , C07D498/10 , A61K31/4439 , A61K31/423 , C07D405/06 , C07D409/06 , C07D403/12 , C07D413/14 , C07D235/02 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D263/52 , C07D491/107 , C07D493/10 , C07D495/10 , C07D401/06
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4439 , C07D235/02 , C07D263/52 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D491/107 , C07D493/10 , C07D495/10 , C07D498/10
摘要： Compounds having a structure of Formula (IX): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, Q1-Q2, R6, R7, A, B, W, x, and y are as defined herein and are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.
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![PYRROLO [2,3-B] PYRIDINE CDK9 KINASE INHIBITORS](/abs-image/US/2016/03/03/US20160060257A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160060257A1
公开(公告)日：2016-03-03
申请号：US14780018
申请日：2014-03-13
申请人： ABBVIE INC.
发明人： Yunsong Tong , Milan Bruncko , Richard F. Clark , Michael Curtin , Alan S. Florjancic , Robin R. Frey , Jianchun Gong , Todd M. Hansen , Zhiqin Ji , Chunqiu Lai , Anthony Mastracchio , Michael Michaelides , Juliem Miyashiro , Roberto M. Risi , Xiaohong Song , Zhi-fu Tao , Keith W. Woods , Guidong Zhu , Thomas Penning , Andrew Souers , Rajeev Goswami , Omprakash Reddy Iquturi , Madhu Babu Dabbeeru
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Disclosed are compounds of Formula (IIa), wherein R1, R2, R3A, R3B, R3C, R3D, R3E, and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIa).
摘要翻译： 公开了式（IIa）的化合物，其中R1，R2，R3A，R3B，R3C，R3D，R3E和R4如说明书中所定义，及其药学上可接受的盐。 这些化合物可以用作治疗包括癌症在内的疾病的药剂。 还提供了包含一种或多种式（IIa）化合物的药物组合物。
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10.发明申请公开(公告)号：US20200246460A1
公开(公告)日：2020-08-06
申请号：US16563507
申请日：2019-09-06
申请人： AbbVie Inc.
发明人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC分类号： A61K45/06 , A61K31/4725 , A61K31/4985 , A61K31/498 , A61K47/68 , A61K31/538 , A61K31/4709 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
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