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公开(公告)号：US09050346B2
公开(公告)日：2015-06-09
申请号：US14203641
申请日：2014-03-11
申请人： AbbVie Inc.
发明人： Lisa A. Hasvold , Dachun Liu , Keith F. McDaniel , John Pratt , George S. Sheppard , Carol K Wada , Kevin R. Woller
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , A61K31/5377 , C07D471/04 , A61K31/496 , A61K31/497 , C07D487/04 , A61K31/501 , A61K31/519
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , C07D471/04 , C07D487/04 , Y02A50/463
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中R1，R2，A1，A2，A3，A4，X和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作 治疗疾病和病症，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。
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公开(公告)号：US20210236508A1
公开(公告)日：2021-08-05
申请号：US16996090
申请日：2020-08-18
申请人： AbbVie Inc.
发明人： Le Wang , John K. Pratt , Keith F. McDaniel , Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James H. Holms , Warren M. Kati , Dachun Liu , Robert A. Mantei , William J. McClellan , George S. Sheppard , Carol K. Wada
IPC分类号： A61K31/541 , C07D487/04 , C07D471/04 , A61K31/437 , A61K31/5025 , A61K31/5377 , A61K45/06
摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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![Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors](/abs-image/US/2018/07/31/US10035800B2/abs.jpg.150x150.jpg)
公开(公告)号：US10035800B2
公开(公告)日：2018-07-31
申请号：US14774866
申请日：2014-03-12
申请人： AbbVie Inc.
发明人： Steven D. Fidanze , Dauchun Liu , Robert A. Mantei , Keith F. McDaniel , John Pratt , George S. Sheppard , Le Wang , Andrew Bogdan , James H. Holms , Justin D. Dietrich , Jasmina Marjanovic , Lisa A. Hasvold , Yujia Dai
IPC分类号： A61K31/437 , C07D471/22 , C07D471/16
CPC分类号： C07D471/22 , A61P13/12 , A61P15/16 , A61P31/18 , A61P35/00 , C07D471/16
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y3, A1, A2, A3 and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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公开(公告)号：US09493411B2
公开(公告)日：2016-11-15
申请号：US14206061
申请日：2014-03-12
申请人： AbbVie Inc.
发明人： Lisa A. Hasvold , John Pratt , Keith F. McDaniel , George S. Sheppard , Dachun Liu , Steven W. Elmore , Robert D. Hubbard
IPC分类号： C07D207/335 , C07D207/36 , C07D207/34 , C07D401/04 , C07D403/04 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D471/04 , A61K31/496 , A61K31/506 , A61K31/381 , A61K31/341 , A61K31/422 , A61K31/4709 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/10 , C07D403/10 , C07D407/12 , C07D409/10 , C07D413/10
CPC分类号： C07D207/34 , C07D207/335 , C07D207/36 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R3, and R10 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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公开(公告)号：US20160143916A1
公开(公告)日：2016-05-26
申请号：US15008994
申请日：2016-01-28
申请人： AbbVie Inc.
发明人： Le Wang , John K. Pratt , Keith F. McDaniel , Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James H. Holms , Warren M. Kati , Dachun Liu , Robert A. Mantei , William J. McClellan , George S. Sheppard , Carol K. Wada
IPC分类号： A61K31/541 , A61K45/06 , A61K31/5025 , A61K31/437 , A61K31/5377
CPC分类号： A61K31/541 , A61K31/437 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐 ，其作为治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂是有用的。 还提供了包含一种或多种式（I）化合物的药物组合物。
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公开(公告)号：US09321764B2
公开(公告)日：2016-04-26
申请号：US14206028
申请日：2014-03-12
申请人： AbbVie Inc.
发明人： Le Wang , John Pratt , Lisa A. Hasvold , Dachun Liu , Yujia Dai , Steven D. Fidanze , James H. Holms , Robert A. Mantei , Keith F. McDaniel , George S. Sheppard , William J. McClellan
IPC分类号： C07D401/04 , A61K31/4353 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂 ，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。
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公开(公告)号：US20140256705A1
公开(公告)日：2014-09-11
申请号：US14203641
申请日：2014-03-11
申请人： Abbvie Inc.
发明人： Lisa A. Hasvold , Dachun Liu , Keith F. McDaniel , John Pratt , George S. Sheppard , Carol K. Wada , Kevin R. Woller
IPC分类号： A61K31/5377 , A61K31/437 , A61K31/519 , A61K31/497 , C07D487/04 , A61K31/501 , C07D471/04 , A61K31/496
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , C07D471/04 , C07D487/04 , Y02A50/463
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中R1，R2，A1，A2，A3，A4，X和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作 治疗疾病和病症，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。
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公开(公告)号：US20200291027A1
公开(公告)日：2020-09-17
申请号：US16827026
申请日：2020-03-23
申请人： AbbVie Inc.
发明人： Steven D. Fidanze , Dachun Liu , Robert A. Mantei , Keith F. McDaniel , John Pratt , George S. Sheppard , Le Wang , Andrew Bogdan , James H. Holms , Justin D. Dietrich , Jasmina Marjanovic , Lisa A. Hasvold , Yujia Dai
IPC分类号： C07D471/22 , A61P15/16 , A61P31/18 , A61P13/12 , A61P35/00 , C07D471/16
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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公开(公告)号：US09428514B2
公开(公告)日：2016-08-30
申请号：US14564352
申请日：2014-12-09
申请人： AbbVie Inc.
发明人： Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号： A01N43/54 , C07D487/04 , C07D211/86 , C07D405/04 , C07D401/04 , C07D417/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D213/69
CPC分类号： A61K31/506 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , C07D211/86 , C07D213/69 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04
摘要： The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中Y1，Y2，R1，R2，R3，A1，A2，A3和A4具有说明书中定义的任何值及其药学上可接受的盐，其是有用的 作为治疗疾病和病症的药剂，包括炎性疾病，癌症和艾滋病。 还提供了由一种或多种式（I）化合物组成的药物组合物。
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公开(公告)号：US20150158873A1
公开(公告)日：2015-06-11
申请号：US14564352
申请日：2014-12-09
申请人： AbbVie Inc.
发明人： Andrew Bogdan , Warren M. Kati , Keith F. McDaniel , Chang H. Park , George S. Sheppard , Le Wang
IPC分类号： C07D487/04 , C07D417/04 , C07D401/04 , C07D211/86 , C07D405/04
CPC分类号： A61K31/506 , A61K31/4412 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/497 , C07D211/86 , C07D213/69 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04
摘要： The present invention provides for compounds of formula (I) wherein Y1, Y2, R1, R2, R3, A1, A2, A3, and A4, have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中Y1，Y2，R1，R2，R3，A1，A2，A3和A4具有说明书中定义的任何值及其药学上可接受的盐，其是有用的 作为治疗疾病和病症的药剂，包括炎性疾病，癌症和艾滋病。 还提供了由一种或多种式（I）化合物组成的药物组合物。
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