公开(公告)号：US20180339970A1

公开(公告)日：2018-11-29

申请号：US15986747

申请日：2018-05-22

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  John J. M. WIENER ,  Olivia D. WEBER ,  Katharine K. DUNCAN

IPC: C07D231/14 ,  C07D401/06 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/06 ,  C07D487/04 ,  C07D519/00 ,  C07D471/10 ,  C07D403/14 ,  C07D413/14 ,  C07D451/02 ,  C07D491/048

CPC classification number: C07D231/14 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180327416A1

公开(公告)日：2018-11-15

申请号：US15777201

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Todd K. JONES ,  Katharine K. DUNCAN ,  Justin S. CISAR ,  Jeffrey E. MERIT ,  Olivia D. WEBER

IPC: C07D487/10 ,  C07D487/04 ,  C07D471/10 ,  C07D519/00 ,  C07D403/06 ,  C07D491/08 ,  C07D231/40 ,  C07D231/38 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12 ,  C07D413/12

CPC classification number: C07D487/10 ,  C07D231/38 ,  C07D231/40 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10 ,  C07D487/04 ,  C07D491/08 ,  C07D498/08 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US20180256566A1

公开(公告)日：2018-09-13

申请号：US15919113

申请日：2018-03-12

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Justin S. CISAR ,  Katharine K. DUNCAN ,  Yu FENG ,  John J.M. WIENER ,  Olivia D. WEBER

IPC: A61K31/496 ,  A61K31/506 ,  A61P25/04

CPC classification number: A61K31/496 ,  A61K31/506 ,  A61K2121/00 ,  A61P25/04

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.