公开(公告)号：US20180339970A1

公开(公告)日：2018-11-29

申请号：US15986747

申请日：2018-05-22

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  John J. M. WIENER ,  Olivia D. WEBER ,  Katharine K. DUNCAN

IPC: C07D231/14 ,  C07D401/06 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/06 ,  C07D487/04 ,  C07D519/00 ,  C07D471/10 ,  C07D403/14 ,  C07D413/14 ,  C07D451/02 ,  C07D491/048

CPC classification number: C07D231/14 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180327410A1

公开(公告)日：2018-11-15

申请号：US15777199

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Todd K. JONES ,  Katherine K. DUNCAN ,  Olivia D. WEBER ,  Justin S. CISAR ,  Jeffrey E. MERIT

IPC: C07D487/04 ,  C07D487/10 ,  C07D403/06 ,  C07D519/00 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14

CPC classification number: C07D487/04 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  C07D487/10 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US20180134674A1

公开(公告)日：2018-05-17

申请号：US15814322

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D295/195

CPC classification number: C07D295/195 ,  C07D295/205

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20170327500A1

公开(公告)日：2017-11-16

申请号：US15593239

申请日：2017-05-11

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Olivia D. WEBER ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D471/10 ,  C07D519/00

CPC classification number: C07D471/10 ,  C07D519/00

Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180327416A1

公开(公告)日：2018-11-15

申请号：US15777201

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Todd K. JONES ,  Katharine K. DUNCAN ,  Justin S. CISAR ,  Jeffrey E. MERIT ,  Olivia D. WEBER

IPC: C07D487/10 ,  C07D487/04 ,  C07D471/10 ,  C07D519/00 ,  C07D403/06 ,  C07D491/08 ,  C07D231/40 ,  C07D231/38 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12 ,  C07D413/12

CPC classification number: C07D487/10 ,  C07D231/38 ,  C07D231/40 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10 ,  C07D487/04 ,  C07D491/08 ,  C07D498/08 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US20180256566A1

公开(公告)日：2018-09-13

申请号：US15919113

申请日：2018-03-12

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Justin S. CISAR ,  Katharine K. DUNCAN ,  Yu FENG ,  John J.M. WIENER ,  Olivia D. WEBER

IPC: A61K31/496 ,  A61K31/506 ,  A61P25/04

CPC classification number: A61K31/496 ,  A61K31/506 ,  A61K2121/00 ,  A61P25/04

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.

公开(公告)号：US20170334874A1

公开(公告)日：2017-11-23

申请号：US15672165

申请日：2017-08-08

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Olivia D. WEBER ,  Dong-Hui WANG

IPC: C07D295/205 ,  C07D207/08 ,  C07D471/10 ,  C07D417/04 ,  C07D403/04 ,  C07D401/04 ,  C07D295/26 ,  C07D265/30 ,  C07D211/62 ,  C07D211/58 ,  C07D211/38 ,  C07D211/14 ,  C07D207/16 ,  C07D207/14 ,  C07D207/12 ,  C07D487/04 ,  C07D498/08

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20190256494A1

公开(公告)日：2019-08-22

申请号：US15777198

申请日：2016-11-18

Applicant: Abide Therapeutics, Inc.

Inventor： Olivia D. WEBER ,  Michael B. SHAGHAFI ,  Cheryl A. GRICE ,  Todd K. JONES

IPC: C07D401/14 ,  A61P25/04 ,  C07D487/10 ,  C07D413/14 ,  C07D491/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US20190202801A1

公开(公告)日：2019-07-04

申请号：US16334335

申请日：2017-09-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI ,  Olivia D. WEBER

IPC: C07D401/10 ,  C07D403/10 ,  C07D413/10 ,  C07D403/14 ,  C07D405/10 ,  C07D471/06 ,  C07D241/04 ,  A61P23/00 ,  A61P29/00 ,  A61P1/00 ,  A61P25/28

CPC classification number: C07D401/10 ,  A61K45/06 ,  A61P1/00 ,  A61P23/00 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/26 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D231/12 ,  C07D241/04 ,  C07D265/30 ,  C07D295/205 ,  C07D309/08 ,  C07D333/38 ,  C07D333/40 ,  C07D401/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D413/10 ,  C07D471/06 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180208568A1

公开(公告)日：2018-07-26

申请号：US15925517

申请日：2018-03-19

Applicant: ABIDE THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Micah J. NIPHAKIS ,  Jae Won CHANG ,  Kenneth M. LUM ,  Benjamin F. CRAVATT

IPC: C07D295/205 ,  C07D491/107 ,  C07C271/10 ,  C07D471/10 ,  C07D471/04 ,  C07D413/10 ,  C07D413/06 ,  C07D407/06 ,  C07D405/14 ,  C07D403/10 ,  C07D401/10 ,  C07D401/04 ,  C07D317/58 ,  C07D317/46 ,  C07D307/79 ,  C07D295/26 ,  C07D271/06 ,  C07D263/32 ,  C07D261/08 ,  C07D241/04 ,  C07D231/56 ,  C07D231/16 ,  C07D231/12 ,  C07D215/46 ,  C07D215/42 ,  C07D213/55 ,  C07D213/40 ,  C07D213/38 ,  C07D207/14 ,  C07D207/09 ,  C07D205/04 ,  C07C271/12 ,  C07D487/04

CPC classification number: C07D295/205 ,  C07C271/10 ,  C07C271/12 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D213/38 ,  C07D213/40 ,  C07D213/55 ,  C07D215/42 ,  C07D215/46 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D295/26 ,  C07D307/79 ,  C07D317/46 ,  C07D317/58 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/14 ,  C07D407/06 ,  C07D413/06 ,  C07D413/10 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107

Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.