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公开(公告)号：US20250145718A1
公开(公告)日：2025-05-08
申请号：US19012836
申请日：2025-01-07
Applicant: ABL BIO INC. , I-MAB BIOPHARMA US LIMITED
Inventor： Eunyoung PARK , Yangsoon LEE , Hyejin CHUNG , Eunsil SUNG , Jiseon YOO , Minji PARK , Yong-Gyu SON , Hyoju CHOI , Eunjung KIM , Jaeho JUNG , Weon-Kyoo YOU , Sang Hoon LEE , Lei FANG , Wenqing JIANG
Abstract: The present disclosure provides a polynucleotide encoding the anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
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公开(公告)号：US20250066487A1
公开(公告)日：2025-02-27
申请号：US18935875
申请日：2024-11-04
Applicant: ABL Bio Inc. , YUHAN CORPORATION
Inventor： Yeryoung YONG , Ui-Jung JUNG , Hyejin CHUNG , Kyeongsu PARK , Wonjun SON , Yangsoon LEE , Yeunju KIM , Eunsil SUNG , Youngkwang KIM , Youngdon PAK , Minji PARK , Jaehyun EOM , Hyoju CHOI , Moo Young SONG , Na Rae LEE , Young Bong PARK , Eun-Jung LEE , Eun-Jung LEE
IPC: C07K16/28 , A61K39/00 , A61K39/395
Abstract: Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
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公开(公告)号：US20250084158A1
公开(公告)日：2025-03-13
申请号：US18580552
申请日：2022-07-20
Applicant: ABL BIO INC.
Inventor： Eunsil SUNG , Junga KWON , Youngkwang KIM , Juhee KIM , Kyungjin PARK , Sumyeong PARK , Byungje SUNG , Byeongmin YOO , Bora LEE , Suyoun LEE , Shinai LEE , Yangsoon LEE , Eunhee LEE , Yangmi LIM , Jaehyoung JEON , Jinwon JUNG
Abstract: Provided are anti-CLL-1 antibodies and uses thereof, according to the anti-CLL-1 antibody of one aspect, it can bind to CLL-1 with high binding affinity, and can cause activation of T cells, thus it can be used effectively for preventing or treating the cancer expressing CLL-1.
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公开(公告)号：US20240383983A1
公开(公告)日：2024-11-21
申请号：US18684660
申请日：2021-08-18
Applicant: ABL BIO, INC.
Inventor： Kyungjin PARK , Yangsoon LEE , Saeyi LIM , Kyeongsu PARK , Minkyu SEON , Wonjun SON , Hyejin CHUNG , Yeryoung YONG , Yong-Gyu SON , Yeunju KIM , Youngdon PAK
Abstract: The present disclosure provides an anti-B7-H4/anti-4-1BB bispecific antibody capable to effectively block the T-cell inhibitory effect of B7-H4 on the surface of tumor cells, and simultaneously activate 4-1BB on T-cells. The bispecific antibody may have high binding affinity to both of a B7-H4 protein (e.g., a human, monkey and mouse B7-H4 protein) and a 4-1BB protein (e.g., a human, monkey and mouse 4-1BB protein). The present disclosure also provides an anti-B7-H4 antibody specifically binds to B7-H4 protein.
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Patent Agency Ranking
公开(公告)号：US20220056136A1
公开(公告)日：2022-02-24
申请号：US17298741
申请日：2019-02-15
Applicant: ABL BIO INC. , I-MAB BIOPHARMA CO., LTD
Inventor： Eunyoung PARK , Yangsoon LEE , Hyejin CHUNG , Eunsil SUNG , Jiseon YOO , Minji PARK , Yong-Gyu SON , Hyoju CHOI , Eunjung KIM , Jaeho JUNG , Weon-Kyoo YOU , Sang Hoon LEE , Lei FANG , Wenqing JIANG
Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
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公开(公告)号：US20210284749A1
公开(公告)日：2021-09-16
申请号：US17053256
申请日：2019-06-26
Applicant: ABL BIO INC.
Inventor： Kyungjin PARK , Hyejin CHUNG , Kyeongsu PARK , Yangsoon LEE , Mikyung CHANG , Jaehyoung JEON , Youngkwang KIM , Junhyun JEONG , Jiseon YOO , Yeunju KIM , Donghoon YEOM , Eunjung KIM , Bora LEE , Jinwon JUNG
Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.
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公开(公告)号：US20250163180A1
公开(公告)日：2025-05-22
申请号：US19034755
申请日：2025-01-23
Applicant: ABL Bio Inc. , YUHAN CORPORATION
Inventor： Hyejin CHUNG , Yeryoung YONG , Kyeongsu PARK , Eunyoung PARK , Ui-Jung JUNG , Yangsoon LEE , Eunjung KIM , Yong-Gyu SON , Wonjun SON , Seawon AHN , Donghoon YEOM , Chanmoo LEE , Junghyeon HONG , Moo Young SONG , Eun-Jung LEE , Na Rae LEE , Young Bong PARK , Eun-Jung LEE , Taewang KIM
Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
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公开(公告)号：US20220363763A1
公开(公告)日：2022-11-17
申请号：US17269784
申请日：2019-08-21
Applicant: ABL BIO INC.
Inventor： Eunyoung PARK , Yangsoon LEE , Uijung JUNG , YoungKwang KIM , Yeun Ju KIM , Youngdon PAK , Sang Hoon LEE , Weon-Kyoo YOU , Jaeho JUNG , Lei FANG , Wenqing JIANG
Abstract: The present disclosure provides an anti-PD-L1/anti-LAG3 bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between LAG3 and its ligand (e.g., a MHC class II molecule and FGL1). The bispecific antibody may have high binding affinity to both of a PD-L1 protein (e.g., a human PD-L1 protein) and a LAG3 protein (e.g., a human LAG3 protein). Also provided are antibodies and fragments that have specificity to the PD-L1 or LAG3 protein alone, or antibodies and fragments having additional specificity to one or more other antigens.
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公开(公告)号：US20220242961A1
公开(公告)日：2022-08-04
申请号：US17296752
申请日：2019-12-02
Applicant: ABL Bio Inc.
Inventor： Eunyoung PARK , Yangsoon LEE , Hyejin CHUNG , Uijung JUNG , Youngdon PAK , Jun Hyun JEONG , Yeunju KIM , Seawon AHN , Byungje SUNG
Abstract: Provided is an anti-4-1 BB antibody or an antigen-binding fragment thereof, and uses thereof.
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