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Patent Agency Ranking
公开(公告)号：US20250145718A1
公开(公告)日：2025-05-08
申请号：US19012836
申请日：2025-01-07
Applicant: ABL BIO INC. , I-MAB BIOPHARMA US LIMITED
Inventor： Eunyoung PARK , Yangsoon LEE , Hyejin CHUNG , Eunsil SUNG , Jiseon YOO , Minji PARK , Yong-Gyu SON , Hyoju CHOI , Eunjung KIM , Jaeho JUNG , Weon-Kyoo YOU , Sang Hoon LEE , Lei FANG , Wenqing JIANG
Abstract: The present disclosure provides a polynucleotide encoding the anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
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公开(公告)号：US20230279085A1
公开(公告)日：2023-09-07
申请号：US16759937
申请日：2018-11-16
Applicant: ABL Bio Inc.
Inventor： Sang Hoon LEE , Weonkyoo YOU , Jinhyung AHN , Sungwon AN , Jinwon JUNG , Bora LEE , Dongin KIM , Byungje SUNG , Yonggyu SON , Yeunju KIM , Jaehyun EOM , Seawon AHN , Youngdon PAK , Donghoon YEOM , Daehae SONG
CPC classification number: C07K16/18 , G01N33/6896 , A61P25/28 , C07K2317/565 , C07K2317/567 , G01N2800/2821 , G01N2800/2835
Abstract: The present invention relates to an anti-alpha-synuclein antibody preferentially recognizing alpha-synuclein aggregates and a use of detection, diagnosis, and/or treatment or prevention of various diseases caused by accumulation of alpha-synuclein aggregates, or their related symptom diseases by using the anti-alpha-synuclein antibody.
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公开(公告)号：US20220056136A1
公开(公告)日：2022-02-24
申请号：US17298741
申请日：2019-02-15
Applicant: ABL BIO INC. , I-MAB BIOPHARMA CO., LTD
Inventor： Eunyoung PARK , Yangsoon LEE , Hyejin CHUNG , Eunsil SUNG , Jiseon YOO , Minji PARK , Yong-Gyu SON , Hyoju CHOI , Eunjung KIM , Jaeho JUNG , Weon-Kyoo YOU , Sang Hoon LEE , Lei FANG , Wenqing JIANG
Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
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公开(公告)号：US20220363763A1
公开(公告)日：2022-11-17
申请号：US17269784
申请日：2019-08-21
Applicant: ABL BIO INC.
Inventor： Eunyoung PARK , Yangsoon LEE , Uijung JUNG , YoungKwang KIM , Yeun Ju KIM , Youngdon PAK , Sang Hoon LEE , Weon-Kyoo YOU , Jaeho JUNG , Lei FANG , Wenqing JIANG
Abstract: The present disclosure provides an anti-PD-L1/anti-LAG3 bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between LAG3 and its ligand (e.g., a MHC class II molecule and FGL1). The bispecific antibody may have high binding affinity to both of a PD-L1 protein (e.g., a human PD-L1 protein) and a LAG3 protein (e.g., a human LAG3 protein). Also provided are antibodies and fragments that have specificity to the PD-L1 or LAG3 protein alone, or antibodies and fragments having additional specificity to one or more other antigens.
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公开(公告)号：US20230227540A1
公开(公告)日：2023-07-20
申请号：US16475853
申请日：2018-01-05
Applicant: ABL Bio Inc.
Inventor： Jinhyung AHN , Sungwon AN , Dongin KIM , Eunsil SUNG , Jaehyun EOM , Sang Hoon LEE , Seung-Jae LEE , Tae Kyung KIM , Min Sun CHOI , Weonkyoo YOU , Jaeho JUNG , Juhee KIM , Jinwon JUNG , Yeunju KIM , Yonggyu SON , Byungje SUNG
CPC classification number: C07K16/18 , A61P25/14 , G01N33/6896 , A61K2039/505 , C07K2317/565
Abstract: The disclosure discloses anti α-Syn antibodies preferentially recognizing α-Syn aggregates. The antibodies of the present invention bind to α-Syn aggregates with high affinity and specificity and inhibit accumulation or intercellular transfer of α-Syn aggregates, and thus can be used for detection, diagnosis and/or treatment or prevention of various diseases caused by the accumulation of α-Syn aggregates.
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