公开(公告)号：US20190277843A1

公开(公告)日：2019-09-12

申请号：US16365579

申请日：2019-03-26

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Chung-YI WU ,  Susan Y. TSENG

IPC: G01N33/553 ,  G01N33/58 ,  C40B50/14 ,  C40B40/12

Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and the slides are more sensitive than transparent glass slides in binding analysis.

公开(公告)号：US20180362662A1

公开(公告)日：2018-12-20

申请号：US16014255

申请日：2018-06-21

Applicant: Academia Sinica

Inventor： Chi-Huey WONG ,  Chung-YI WU

IPC: C07K16/40 ,  C12P21/00 ,  C07K16/28 ,  C07K16/32 ,  A61K31/517 ,  A61K39/395

Abstract: The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.