公开(公告)号：US10238631B2

公开(公告)日：2019-03-26

申请号：US15316700

申请日：2015-06-05

Applicant: Academia Sinica

Inventor： Lie-Fen Shyur ,  Kuo-Hsiung Lee ,  Kyoko Nakagawa-Goto ,  Jia-Hua Feng ,  Jo-Yu Chen ,  Wai-Leng Lee ,  Yu-Ting Cheng ,  Jing-Ying Huang

IPC: A61K31/365 ,  A61K45/06 ,  A61K31/337 ,  A61K31/437 ,  C07D493/18 ,  A61K31/198 ,  A61K31/655

Abstract: A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

公开(公告)号：US10434132B2

公开(公告)日：2019-10-08

申请号：US16172428

申请日：2018-10-26

Applicant: ACADEMIA SINICA

Inventor： Lie-Fen Shyur ,  Jia-Hua Feng ,  Maria Karmella Apaya

IPC: A61K36/00 ,  A61K36/88 ,  A61K31/25 ,  A61K36/28 ,  A61K8/9794 ,  A61Q19/02 ,  A61P1/16 ,  A61P31/04

Abstract: The present invention is related to a galactolipids-enriched plant extract, prepared by extracting a plant sample selected from a group consisting of: Gynura divaricata subsp. formosana (Asteraceae) (GD), Murdannia bracteata (C. B. Clarke) J. K. Morton ex D. Y. Hong (Commelinaceae) (MB), and Crassocephalum rabens S. Moore (Asteraceae) (CR) with a series of solvents. A pharmaceutical, nutritional, or healthcare composition for protecting or treating acute fulminant hepatitis, for protecting or treating sepsis or related indication thereof, and a composition for skin whitening are also provided herein. These compositions all comprise effective amounts of the galactolipids-enriched plant extracts or purified compounds thereof as bioactive ingredients.