公开(公告)号：US11918641B2

公开(公告)日：2024-03-05

申请号：US17998208

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/145 ,  A61K35/76 ,  A61K39/00 ,  A61K39/12 ,  A61P31/16 ,  C07K14/005 ,  C07K14/11

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US12178870B2

公开(公告)日：2024-12-31

申请号：US18662436

申请日：2024-05-13

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/145 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61P31/16 ,  C07K14/005 ,  C07K14/11

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US12157763B2

公开(公告)日：2024-12-03

申请号：US18403419

申请日：2024-01-03

Applicant: ACADEMIA SINICA

Inventor： Kuo-I Lin ,  Che Ma ,  Chi-Huey Wong ,  Szu-Wen Wang ,  Yi-Hsuan Chang ,  Xiaorui Chen ,  Han-Yi Huang

IPC: C07K16/10 ,  A61K39/42 ,  A61K39/00

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.

公开(公告)号：US11992525B2

公开(公告)日：2024-05-28

申请号：US18501578

申请日：2023-11-03

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Hsin-Yu Liao ,  Shih-Chi Wang ,  Yi-An Ko ,  Kuo-I Lin ,  Che Ma ,  Ting-Jen Cheng

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61P31/16 ,  C07K14/005

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US11866485B2

公开(公告)日：2024-01-09

申请号：US17937744

申请日：2022-10-03

Applicant: ACADEMIA SINICA

Inventor： Kuo-I Lin ,  Che Ma ,  Chi-Huey Wong ,  Szu-Wen Wang ,  Yi-Hsuan Chang ,  Xiaorui Chen ,  Han-Yi Huang

IPC: C07K16/10 ,  A61K39/42 ,  A61K39/00

CPC classification number: C07K16/10 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure relates to an antibody or antigen-binding fragment thereof that specifically binds to a spike protein of SARS-CoV-2. The present disclosure also relates to a pharmaceutical composition, a method for treating and/or preventing diseases and/or disorders caused by a coronavirus in a subject in need thereof, and a method for detecting a coronavirus in a sample.