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公开(公告)号：US20210332146A1
公开(公告)日：2021-10-28
申请号：US17211619
申请日：2021-03-24
Applicant: ACADEMIA SINICA
Inventor： Chi-Huey WONG , Chung-Yi WU , Ming-Hung Tsai
Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
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公开(公告)号：US20150344585A1
公开(公告)日：2015-12-03
申请号：US14723020
申请日：2015-05-27
Applicant: Academia Sinica
Inventor： Chi-Huey WONG , Chung-Yi Wu , Ming-Hung Tsai
CPC classification number: C07K16/2887 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/283 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C12P21/005 , C12Y302/01 , C12Y302/01051
Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
Abstract translation: 本公开涉及一类新的抗CD20单克隆抗体，其包含在Fc上具有相同N-聚糖的均匀的抗CD20IgG分子群。 本发明的抗体可以通过Fc糖工程从抗CD20单克隆抗体产生。 重要的是，本发明的抗体具有改善的治疗价值，与尚未糖基化的相应单克隆抗体相比，具有增加的ADCC活性和增加的Fc受体结合亲和力。
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公开(公告)号：US11884739B2
公开(公告)日：2024-01-30
申请号：US17211619
申请日：2021-03-24
Applicant: ACADEMIA SINICA
Inventor： Chi-Huey Wong , Chung-Yi Wu , Ming-Hung Tsai
CPC classification number: C07K16/2887 , C07K16/283 , C12P21/005 , C12Y302/01 , C12Y302/01051 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/732 , C07K2317/734 , C07K2317/92
Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
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