公开(公告)号：US20240316014A1

公开(公告)日：2024-09-26

申请号：US18126273

申请日：2023-03-24

Applicant: ACADEMIA SINICA ,  GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Joyce Jean LU ,  Hsiao-Chun Huang ,  Pei-Lun La ,  Chi-Hou Ng ,  Ming-Hsi Chuang

IPC: A61K31/44 ,  A61K9/00 ,  A61K31/352 ,  A61K31/404 ,  A61P25/00

CPC classification number: A61K31/44 ,  A61K9/0019 ,  A61K9/0085 ,  A61K31/352 ,  A61K31/404 ,  A61P25/00

Abstract: The present invention generally relates to a method for treating a demyelinating condition, in particular, by administering a combination comprising therapeutically effective amounts of a Rho-associated protein kinase (ROCK) inhibitor, a cyclin-dependent kinase (CDK) inhibitor, and a cyclic adenosine monophosphate (cAMP) activator to a subject in need thereof.

公开(公告)号：US20220090023A1

公开(公告)日：2022-03-24

申请号：US17418619

申请日：2019-12-26

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Wei-Ju CHEN

IPC: C12N5/074 ,  C12N5/00 ,  C12N15/86 ,  C12N15/873 ,  C12N15/85 ,  C07K14/435

Abstract: The present invention relates to a method for regulating potency of pluripotent stem cells (PSCs) by modulating expression of podocalyxin-like protein 1 (PODXL) and applications thereof.

公开(公告)号：US20210147796A1

公开(公告)日：2021-05-20

申请号：US16620395

申请日：2018-06-06

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Yu-Tsen LIN

IPC: C12N5/00 ,  C07D307/04 ,  C12N5/0775

Abstract: The present invention relates to a method for removing undifferentiated embryonic stem cells. In particular, the present invention relates to a method for removing undifferentiated embryonic stem cells by using cardiac glycosides (CGs). The present invention also relates to a method for preparing differentiated cells in which undifferentiated embryonic stem cells have been removed and a method for cell therapy by using such differentiated cells.

公开(公告)号：US20210246422A1

公开(公告)日：2021-08-12

申请号：US17251335

申请日：2019-06-14

Applicant: ACADEMIA SINICA

Inventor： Joyce Jean LU ,  Hsiao-Chun HUANG ,  Pei-Lun LAI ,  Chi-Hou NG

IPC: C12N5/079 ,  A61K35/30

Abstract: The present invention generally relates to a method for generating induced oligodendrocyte-lineage cells (induced OLGs) and treatment using such cells. The induced OLGs are useful in cell therapy, in particular for demyelinating diseases.