公开(公告)号：US20210220377A1

公开(公告)日：2021-07-22

申请号：US17070271

申请日：2020-10-14

申请人： Academy of Military Medical Sciences

发明人： Wu ZHONG ,  Ruiyuan Cao ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Leike Zhang ,  Wei Li ,  Yuexiang Li ,  Lei Zhao ,  Shiyong Fan ,  Song Li

IPC分类号： A61K31/685 ,  A61P31/14

摘要： The present application relates to use of a substituted aminopropionate compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for the treatment of a disease or an infection caused by a SARS-CoV-2.

公开(公告)号：US20230077704A1

公开(公告)日：2023-03-16

申请号：US17794145

申请日：2020-07-15

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Ruiyan Cao ,  Leike Zhang ,  Wei Li ,  Yuexiang Li ,  Lei Zhao ,  Song Li

IPC分类号： A61K31/426 ,  A61P31/14

摘要： Nitazoxanide represented by formula I and an active form thereof, tizoxanide compound, represented by formula II, a geometric isomer thereof and pharmaceutically acceptable salt thereof and/or solvate thereof and/or hydrate thereof, and a pharmaceutical composition containing this compound, used for preventing and/or treating coronavirus (such as SARS-CoV-2) infection.

公开(公告)号：US20230218606A1

公开(公告)日：2023-07-13

申请号：US17795471

申请日：2020-06-02

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Leike Zhang ,  Ruiyuan Cao ,  Wei Li ,  Shiyong Fan ,  Xinbo Zhou ,  Song Li

IPC分类号： A61K31/4706 ,  A61P31/14

CPC分类号： A61K31/4706 ,  A61P31/14

摘要： Disclosed are hydroxychloroquine or chloroquine, or a geometric isomer thereof, or a pharmaceutically acceptable salt thereof, and/or a solvate thereof, and/or a hydrate thereof, and a pharmaceutical composition containing the above-mentioned compound, and the use thereof in the treatment of diseases or infections caused by SARS-CoV-2.

公开(公告)号：US20230071014A1

公开(公告)日：2023-03-09

申请号：US17797048

申请日：2020-07-15

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Zhihong Hu ,  Gengfu Xiao ,  Ruiyuan Cao ,  Manli Wang ,  Leike Zhang ,  Wei Li ,  Shiyong Fan ,  Song Li

IPC分类号： A61K31/427 ,  A61P31/14

摘要： A use of ritonavir, or a geometric isomer, pharmaceutically acceptable salt, solvate, and/or hydrate thereof, and a pharmaceutical composition containing the above compound in treating a SARS-CoV-2 infections.

公开(公告)号：US11318135B2

公开(公告)日：2022-05-03

申请号：US17378361

申请日：2021-07-16

申请人： Academy of Military Medical Sciences

发明人： Wu Zhong ,  Ruiyuan Cao ,  Cheng Cao ,  Ting Gao ,  Gengfu Xiao ,  Zhihong Hu ,  Manli Wang ,  Leike Zhang ,  Song Li

IPC分类号： A61K31/4965 ,  A61P31/14

摘要： The present application relates to a Favipiravir compound represented by Formula I, a geometric isomer, a pharmaceutically acceptable salt, a solvate and/or a hydrate thereof, and a pharmaceutical composition comprising the compound for treating a coronavirus infection.