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公开(公告)号：US20190153062A1
公开(公告)日：2019-05-23
申请号：US15759779
申请日：2016-09-15
Applicant: IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
Inventor： Annelise Brigitte Vuidepot , Bent Karsten Jakobsen , Nathaniel Ross Liddy , Peter Eamon Molloy
IPC: C07K14/725 , C12N15/10
Abstract: The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV17 gene product and the beta chain variable domain comprises a TRBV2 gene product.
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公开(公告)号：US20180346904A1
公开(公告)日：2018-12-06
申请号：US15759791
申请日：2016-09-15
Applicant: IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
Inventor： Bent Karsten Jakobsen , Nathaniel Ross Liddy , Peter Eamon Molloy , Annelise Brigitte Vuidepot
IPC: C12N15/10 , C07K14/725
CPC classification number: C07K14/7051
Abstract: The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV38 gene product and the beta chain variable domain comprises a TRBV2 gene product.
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公开(公告)号：US20180340167A1
公开(公告)日：2018-11-29
申请号：US15759784
申请日：2016-09-15
Applicant: IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
Inventor： Bent Karsten Jakobsen , Nathaniel Ross Liddy , Peter Eamon Molloy , Annelise Brigitte Vuidepot
IPC: C12N15/10 , C07K14/725
Abstract: The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV13-1 gene product and the beta chain variable domain comprises a TRBV4 gene product.
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公开(公告)号：US11124556B2
公开(公告)日：2021-09-21
申请号：US15759775
申请日：2016-09-15
Applicant: ADAPTIMMUNE LIMITED , IMMUNOCORE LIMITED
Inventor： Bent Karsten Jakobsen , Nathaniel Ross Liddy , Peter Eamon Molloy , Annelise Brigitte Vuidepot
IPC: C40B40/10 , C07K14/725 , C12N15/10 , C40B40/02
Abstract: The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV12-2 gene product and the beta chain variable domain comprises a TRBV gene product.
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公开(公告)号：US11017882B2
公开(公告)日：2021-05-25
申请号：US14741828
申请日：2015-06-17
Applicant: IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
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Patent Agency Ranking
公开(公告)号：US09447410B2
公开(公告)日：2016-09-20
申请号：US14249904
申请日：2014-04-10
Applicant: ADAPTIMMUNE LIMITED , IMMUNOCORE LIMITED
Inventor： Bent Karsten Jakobsen , Peter Eamon Molloy , Yi Li , Jonathan Michael Boulter
CPC classification number: C12N15/1037 , A61K38/00 , C07K14/7051 , C12N7/00 , C12N15/1041 , C12N15/1058 , C12N2795/18121 , C12N2795/18143 , C40B40/02 , C40B40/10
Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
Abstract translation: 蛋白质颗粒，例如噬菌体，核糖体或细胞，在其表面上显示T细胞受体（TCR）。 显示的TCR优选是在恒定结构域残基之间具有非天然二硫键的异源二聚体。 这种显示颗粒可用于创建用于鉴定高亲和性TCR的多种TCR文库。 披露了几个高亲和力。
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公开(公告)号：US20140371085A1
公开(公告)日：2014-12-18
申请号：US14248919
申请日：2014-04-09
Applicant: ADAPTIMMUNE LIMITED , IMMUNOCORE LIMITED
Inventor： Bent Karsten Jakobsen , Torben Bent Andersen , Peter Eamon Molloy , Yi Li
IPC: C12N15/10
CPC classification number: C12N15/1037 , A61K38/00 , C07K14/7051 , C12N7/00 , C12N15/1041 , C12N15/1058 , C12N2795/18121 , C12N2795/18143 , C40B40/02 , C40B40/10
Abstract: A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identification of high affinity TCRs. Several high affinities are disclosed.
Abstract translation: 蛋白质颗粒，例如噬菌体，核糖体或细胞，在其表面上显示T细胞受体（TCR）。 显示的TCR优选是在恒定结构域残基之间具有非天然二硫键的异源二聚体。 这种显示颗粒可用于创建用于鉴定高亲和性TCR的多种TCR文库。 披露了几个高亲和力。
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公开(公告)号：US11929151B2
公开(公告)日：2024-03-12
申请号：US17158940
申请日：2021-01-26
Applicant: Immunocore Limited , Adaptimmune Limited
CPC classification number: G16B35/20 , G01N33/505 , G01N33/6866 , G01N33/6878 , G16B35/00 , G16C20/60 , G01N2333/57 , G01N2333/70539 , G01N2500/04
Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
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公开(公告)号：US20210395332A1
公开(公告)日：2021-12-23
申请号：US17406954
申请日：2021-08-19
Applicant: ADAPTIMMUNE LIMITED , IMMUNOCORE LIMITED
Inventor： Bent Karsten Jakobsen , Nathaniel Ross Liddy , Peter Eamon Molloy , Annelise Brigitte Vuidepot
IPC: C07K14/725 , C12N15/10 , C40B40/02 , C40B40/10
Abstract: The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain and a beta chain variable domain, wherein the alpha chain variable domain comprises a TRAV12-2 gene product and the beta chain variable domain comprises a TRBV gene product.
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公开(公告)号：US10937524B2
公开(公告)日：2021-03-02
申请号：US14741828
申请日：2015-06-17
Applicant: IMMUNOCORE LIMITED , ADAPTIMMUNE LIMITED
Abstract: The invention provides a method for predicting whether a binding peptide, which binds to a target peptide presented by a Major Histocompatibility Complex (MHC) and is for administration to a subject, has the potential to cross react with another peptide in the subject in vivo. The method comprises the steps of identifying at least one binding motif in the target peptide to which the binding peptide binds; and searching for peptides that are present in the subject that comprise the at least one binding motif and that are not the target peptide. The presence of one or more such peptides indicates that the binding peptide has the potential to cross react in vivo.
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