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1.发明申请公开(公告)号：US20180296548A1
公开(公告)日：2018-10-18
申请号：US15767339
申请日：2016-10-14
申请人： ADVANCED BIODESIGN
IPC分类号： A61K31/4453 , A61K31/255 , A61K31/5375 , A61P35/00 , A61P35/02 , G01N33/50
摘要： The present invention relates to the treatment of cancer in a subject, wherein cancer cells of said subject overproduce H2O2 and have a level of GSH below 0.5 nmol for 25 000 cells, with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate. It also relates to a method for selecting a subject suffering from a cancer and who will most likely benefit from a treatment with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate.
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公开(公告)号：US20180303773A1
公开(公告)日：2018-10-25
申请号：US15768468
申请日：2016-10-14
申请人： ADVANCED BIODESIGN
IPC分类号： A61K31/145 , A61P35/02 , G01N21/64 , G01N33/574 , G01N33/68 , G01N33/84
CPC分类号： A61K31/145 , A61K31/131 , A61K31/136 , A61K31/137 , A61K31/4453 , A61K31/498 , A61K31/5375 , A61K31/704 , A61K33/24 , A61K33/36 , A61K45/06 , A61K2300/00 , A61P35/02 , G01N21/64 , G01N33/57496 , G01N33/68 , G01N33/84 , G01N2440/00
摘要： The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H2O2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H2O2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.
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3.发明申请公开(公告)号：US20190169313A1
公开(公告)日：2019-06-06
申请号：US16309860
申请日：2017-06-14
申请人： ADVANCED BIODESIGN
IPC分类号： C07K16/44 , G01N33/53 , G01N33/68 , G01N33/558
摘要： The present invention concerns an ex vivo method for the monitoring of apoptosis which is based on the detection of free gamma-glutamyl-L-epsilon-Lysine (GGEL) in a biological sample of a subject with a monoclonal antibody specific to GGEL. The invention also relates to the monoclonal antibody specific to GGEL, as well as to diagnostic kits containing such a ligand.
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4.发明公开公开(公告)号：US20230149378A1
公开(公告)日：2023-05-18
申请号：US17993003
申请日：2022-11-23
申请人： ADVANCED BIODESIGN
IPC分类号： A61K31/4453 , A61K31/5375 , A61K31/131 , A61K31/136 , A61K31/137 , G01N33/84 , G01N33/68 , G01N33/574 , A61P35/02 , A61P35/00 , A61K31/255 , G01N33/50
CPC分类号： A61K31/4453 , A61K31/5375 , A61K31/131 , A61K31/136 , A61K31/137 , G01N33/84 , G01N33/68 , G01N33/574 , A61P35/02 , A61P35/00 , A61K31/255 , G01N33/5011 , G01N2800/52
摘要： The present invention relates to the treatment of cancer in a subject, wherein cancer cells of said subject overproduce H2O2 and have a level of GSH below 0.5 nmol for 25 000 cells, with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate. It also relates to a method for selecting a subject suffering from a cancer and who will most likely benefit from a treatment with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate.
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