公开(公告)号：US10155792B2

公开(公告)日：2018-12-18

申请号：US14427102

申请日：2013-09-25

Applicant: AFFIBODY AB

Inventor： Caroline Ekblad ,  Joachim Feldwisch ,  Kyong-Hoon Ahn

IPC: C07K14/195 ,  A61K38/00 ,  C07K14/315 ,  A61K47/48

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to albumin binding polypeptides which have a high resistance to enzymatic cleavage. The disclosure provides an albumin binding polypeptide comprising an albumin binding motif, which motif consists of the amino acid sequence GVSDFYKKLI XaKAKTVEGVE ALKXbXcI (SEQ ID NO:29).

公开(公告)号：US20150225464A1

公开(公告)日：2015-08-13

申请号：US14427102

申请日：2013-09-25

Applicant: AFFIBODY AB

Inventor： Caroline Ekblad ,  Joachim Feldwisch ,  Kyong-Hoon Ahn

IPC: C07K14/195 ,  A61K47/48

CPC classification number: C07K14/195 ,  A61K47/64 ,  C07K14/315 ,  C07K2319/00 ,  C07K2319/31

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to albumin binding polypeptides which have a high resistance to enzymatic cleavage. The disclosure provides an albumin binding polypeptide comprising an albumin binding motif, which motif consists of the amino acid sequence GVSDFYKKLI XaKAKTVEGVE ALKXbXcI (SEQ ID NO:29).

Abstract translation: 本公开涉及对白蛋白具有结合亲和力的一类工程改造的多肽。 特别地，本发明涉及对酶裂解具有高抗性的白蛋白结合多肽。 本公开提供了包含白蛋白结合基序的白蛋白结合多肽，该基序由氨基酸序列GVSDFYKKLI XaKAKTVEGVE ALKXbXcI（SEQ ID NO：29）组成。