公开(公告)号：US10993917B2

公开(公告)日：2021-05-04

申请号：US16343434

申请日：2017-12-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Susi Tan

IPC: A61K9/50 ,  A61P35/00 ,  A61K47/61 ,  A61K33/243 ,  A61K9/51 ,  A61K31/282 ,  A61K31/41 ,  A61K31/555 ,  A61K47/69 ,  A61K31/665

Abstract: There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.

公开(公告)号：US20190262271A1

公开(公告)日：2019-08-29

申请号：US16343434

申请日：2017-12-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Susi Tan

IPC: A61K9/50 ,  A61K9/51 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282

Abstract: There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.

公开(公告)号：US20170258757A1

公开(公告)日：2017-09-14

申请号：US15598407

申请日：2017-05-18

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Kun Liang ,  Susi Tan ,  Joo Eun Chung ,  Jackie Y. Ying

IPC: A61K31/282 ,  A61K9/107 ,  A61K31/353 ,  A61K31/704 ,  A61K31/7088 ,  A61K45/06 ,  A61K9/00 ,  A61K31/337

CPC classification number: A61K31/282 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/337 ,  A61K31/353 ,  A61K31/704 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/60 ,  A61K2300/00

Abstract: There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.