公开(公告)号：US10463646B2

公开(公告)日：2019-11-05

申请号：US16039098

申请日：2018-07-18

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Yongvongsoontorn Nunnarpas ,  Jackie Y. Ying ,  Joo Eun Chung ,  Ki Hyun Bae ,  Min-Han Tan ,  Esther Lee

IPC: A61K31/404 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333 ,  A61K31/353 ,  A61K47/10 ,  A61K9/107 ,  C08L1/02 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/16 ,  C08L89/00 ,  A61K47/60 ,  A61K31/704 ,  A61K47/59 ,  B82Y5/00

Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

公开(公告)号：US10052307B2

公开(公告)日：2018-08-21

申请号：US15309675

申请日：2015-05-08

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Yongvongsoontorn Nunnarpas ,  Jackie Y Ying ,  Joo Eun Chung ,  Ki Hyun Bae ,  Min-han Tan ,  Esther Lee

IPC: A61K31/353 ,  A61K31/404 ,  A61K47/48 ,  C08G65/331 ,  A61K47/10 ,  A61K9/107 ,  C08L1/02 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/16 ,  C08L89/00 ,  C08G65/332 ,  C08G65/333 ,  A61K31/704 ,  A61K47/60 ,  B82Y5/00

CPC classification number: A61K31/404 ,  A61K9/107 ,  A61K31/353 ,  A61K31/704 ,  A61K47/10 ,  A61K47/59 ,  A61K47/60 ,  B82Y5/00 ,  C08G65/331 ,  C08G65/3315 ,  C08G65/3317 ,  C08G65/3318 ,  C08G65/332 ,  C08G65/3326 ,  C08G65/3328 ,  C08G65/33396 ,  C08L1/02 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C08L5/16 ,  C08L89/00 ,  C08L2203/02

Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.

公开(公告)号：US10716959B2

公开(公告)日：2020-07-21

申请号：US14916559

申请日：2014-09-01

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae

IPC: A61K47/48 ,  A61K9/06 ,  A61K8/73 ,  A61K8/49 ,  A61K9/00 ,  A61K31/353 ,  A61K8/04 ,  A61Q19/00 ,  C07D311/32 ,  A61K8/81 ,  A61K47/61 ,  A61K47/36 ,  A61K47/32

Abstract: There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.

公开(公告)号：US20190262271A1

公开(公告)日：2019-08-29

申请号：US16343434

申请日：2017-12-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Susi Tan

IPC: A61K9/50 ,  A61K9/51 ,  A61P35/00 ,  A61K33/243 ,  A61K31/282

Abstract: There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.

公开(公告)号：US10993917B2

公开(公告)日：2021-05-04

申请号：US16343434

申请日：2017-12-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Susi Tan

IPC: A61K9/50 ,  A61P35/00 ,  A61K47/61 ,  A61K33/243 ,  A61K9/51 ,  A61K31/282 ,  A61K31/41 ,  A61K31/555 ,  A61K47/69 ,  A61K31/665

Abstract: There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.

公开(公告)号：US10052389B2

公开(公告)日：2018-08-21

申请号：US14767784

申请日：2014-02-13

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Fan Lee

IPC: A61K47/61 ,  A61K47/69 ,  A61K47/48 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/04 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L15/44 ,  A61L15/60 ,  A61K9/00 ,  A61K47/10 ,  A61K47/36 ,  A61K38/21 ,  A61K38/28 ,  A61K38/38 ,  C08B37/02 ,  C08L5/02 ,  A61K47/60

CPC classification number: A61K47/61 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/21 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K47/10 ,  A61K47/36 ,  A61K47/60 ,  A61K47/6903 ,  A61L15/44 ,  A61L15/60 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/042 ,  A61L31/043 ,  A61L31/129 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2400/06 ,  C08B37/0021 ,  C08L5/02 ,  C08L89/00 ,  C08L5/00 ,  C08L71/02

Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

公开(公告)号：US20150374838A1

公开(公告)日：2015-12-31

申请号：US14767784

申请日：2014-02-13

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Motoichi Kurisawa ,  Ki Hyun Bae ,  Fan Lee

IPC: A61K47/48 ,  A61K38/21 ,  A61K9/00 ,  A61K38/38 ,  A61K38/28

CPC classification number: A61K47/61 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/21 ,  A61K38/212 ,  A61K38/28 ,  A61K38/385 ,  A61K47/10 ,  A61K47/36 ,  A61K47/60 ,  A61K47/6903 ,  A61L15/44 ,  A61L15/60 ,  A61L27/20 ,  A61L27/22 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L31/042 ,  A61L31/043 ,  A61L31/129 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/622 ,  A61L2400/06 ,  C08B37/0021 ,  C08L5/02 ,  C08L89/00 ,  C08L5/00 ,  C08L71/02

Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.

Abstract translation: 本公开涉及一种用于释放活性剂的聚合物体系，其包含含有活性剂的第一聚合物相，所述第一聚合物相形成一定大小范围的离散区域并分散在包含交联的第二聚合物相 聚合物 - 苯酚共轭物用于其中活性剂的释放。 本公开进一步提供了包含所公开的聚合物体系的可注射水凝胶，用于递送生物活性物质的载体或包含可注射水凝胶的药物，以及用于制备所公开的聚合物体系的方法。