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    METHODS OF DIAGNOSING CANCER
    1.
    发明申请
    METHODS OF DIAGNOSING CANCER 审中-公开

    公开(公告)号：US20190083436A1

    公开(公告)日：2019-03-21

    申请号：US16083394

    申请日：2017-03-08

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Weiping HAN ,  Russell E. ERICKSEN

    IPC: A61K31/198 ,  A23L33/175 ,  G01N33/574 ,  C12Q1/6886

    Abstract: Disclosed are two methods of treating or preventing a proliferative disease as characterized and/or diagnosed by at least one selected from an accumulation of branched-chain amino acid(s) (BCAA), suppression of activity or transcripts level of BCAA catabolic enzyme(s) and a decrease in acylcarnitine level (C5:1), one comprising the administration of a BCAA catabolism enhancer and/or branched chain alpha-ketoacid dehydrogenase complex (BCKDC) kinase inhibitor and the other comprising administration of a meal replacement with low BCAA levels. In three separate embodiments, methods of diagnosis or prognosis are disclosed, each comprising the measurement of the levels of a different marker, i.e. BCAA, BCAA catabolic enzymes or acylcarnitine (C5:1). In preferred embodiments, the proliferative disease is cancer. Also disclosed is a kit or microarray chip useful for methods thereof.

    DERMATOPONTIN AS A THERAPEUTIC FOR METABOLIC DISORDERS
    3.
    发明申请
    DERMATOPONTIN AS A THERAPEUTIC FOR METABOLIC DISORDERS 审中-公开

    公开(公告)号：US20180036371A1

    公开(公告)日：2018-02-08

    申请号：US15550768

    申请日：2016-02-11

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Wanjin HONG ,  Shixiong TAN ,  Weiping HAN

    IPC: A61K38/17

    CPC classification number: A61K38/1709 ,  A61K38/16 ,  G01N33/6893 ,  G01N2800/02 ,  G01N2800/04 ,  G01N2800/042

    Abstract: The present disclosure describes to a method of treating a metabolic disease in a subject, wherein the method comprises administration of dermatopontin to a subject, wherein the dermatopontin is recombinant dermatopontin and the metabolic disease is selected from a group consisting of weight gain, diet-induced weight gain, obesity, morbid obesity, metabolic syndrome, glucose homeostasis, insulin resistance, type I diabetes, type if diabetes and cardiovascular disease. Disclosed herein is also a method of determining or making a prognosis of a subject's susceptibility to metabolic diseases and obesity, the method comprising measuring the level of circulating dermatopontin in a sample obtained from a subject; and comparing the level of circulating dermatopontin obtained with the level of dermatopontin previously determined in a control; and determining the susceptibility of the subject to metabolic disease and obesity based on the difference between the level of circulating dermatopontin and the level of dermatopontin in the control.

    METHOD OF IDENTIFYING ADIPOSE STEM CELLS
    5.
    发明申请
    METHOD OF IDENTIFYING ADIPOSE STEM CELLS 审中-公开
    鉴定ADIPOSE干细胞的方法

    公开(公告)号：US20160187317A1

    公开(公告)日：2016-06-30

    申请号：US14907269

    申请日：2014-08-01

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Shigeki SUGI ,  Wee Kiat ONG ,  Weiping HAN

    IPC: G01N33/50

    CPC classification number: G01N33/5005 ,  C12N5/0667 ,  C12N2501/115 ,  G01N33/6872 ,  G01N2333/70596 ,  G01N2500/10

    Abstract: Disclosed is a method of identifying the origin of adipose-derived stem cells, comprising detecting at least one cell-surface marker selected from a group consisting of CD 10, CD141, CD 142 and CD200. Also disclosed are methods of determining adipogenic capability of a cell capable of adipogenesis by determining the presence of CD 10 or CD200.

    Abstract translation: 公开了一种鉴定脂肪来源的干细胞起源的方法，包括检测至少一种选自CD10，CD141，CD142和CD200的细胞表面标志物。 还公开了通过确定CD10或CD200的存在来确定能够脂肪形成的细胞的脂肪形成能力的方法。

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