专利检索 ap:("AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH" OR "TESSA THERAPEUTICS PTE. LTD.") AND inv:"Shu WANG" 第 1 页

1.

发明申请
A METHOD TO UP-REGULATE CANCER STEM CELL MARKERS FOR THE GENERATION OF ANTIGEN SPECIFIC CYTOTOXIC EFFECTOR T CELLS 审中-公开

公开(公告)号：US20170191034A1

公开(公告)日：2017-07-06

申请号：US15508897

申请日：2015-09-04

申请人： AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH , TESSA THERAPEUTICS PTE. LTD.

发明人： Shu WANG , Chunxiao WU , Jieming ZENG , Yovita Ida PURWANTI , Andrew KHOO

IPC分类号： C12N5/0784 , C12N5/095

CPC分类号： C12N5/0639 , A61K35/15 , A61K39/0011 , A61K2039/5154 , A61K2039/572 , C12N5/0695 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/30 , C12N2502/45 , C12N2506/30

摘要： The invention concerns a method of preparing a composition comprising stimulated immune system cells such as dendritic cells (DC) for use in inducing immune response of cytotoxic T lymphocytes against colorectal cancer. The dendritic cells are pulsed by contact with colorectal cancer stem cells (CSC) or their fragments thereof. These colorectal CSCs are produced by OSKM (Oct4, Sox2, Klf4 and c-Myc) induced reprogramming of differentiated colorectal cancer cells (CRC) which results in undifferentiated colorectal CSC-like cells. Both the CSC-like cells and the lysates of heat-shocked CSC-like cells could be used as an accessible source of tumour antigens for DC pulsing to induce specific immune responses against colorectal CSCs.

2.

发明申请
METHOD FOR ANTIGEN LOADING OF DENDRITIC CELLS AND VACCINE 审中-公开

公开(公告)号：US20180078627A1

公开(公告)日：2018-03-22

申请号：US15563542

申请日：2016-03-28

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TESSA THERAPEUTICS PTE. LTD.

发明人： Jieming ZENG , Shu WANG , Andrew KHOO

IPC分类号： A61K39/00 , C12N5/0784 , C12N7/00 , C07K14/47 , C07K14/435

CPC分类号： A61K39/0011 , A61K35/15 , A61K2039/5154 , A61K2039/5156 , A61K2039/57 , A61K2039/572 , C07K14/435 , C07K14/4748 , C07K2319/95 , C12N5/0639 , C12N7/00 , C12N2501/22 , C12N2501/2304 , C12N2502/1394 , C12N2506/02 , C12N2510/00 , C12N2740/15043

摘要： There is provided a method of loading antigen in a dendritic cell for antigen presentation, the method comprising: modifying a pluripotent stem cell with a nucleic acid molecule encoding an antigen or one or more immunogenic epitopes thereof; inducing the pluripotent stem cell to differentiate into a dendritic cell that expresses and presents the antigen or the one or more immunogenic epitopes thereof. Dendritic cells, vaccines and methods of using the dendritic cells and vaccines are also provided.