公开(公告)号：US20170312355A1

公开(公告)日：2017-11-02

申请号：US15594167

申请日：2017-05-12

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  TESSA THERAPEUTICS PTE. LTD. ,  SINGAPORE HEALTH SERVICES PTE. LTD.

发明人： John CONNOLLY ,  Richard HOPKINS ,  Han Chong TOH

IPC分类号： A61K39/245 ,  C12Q1/70 ,  G01N33/574 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K35/17 ,  A61K2039/5158 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/585 ,  C12N7/00 ,  C12N2710/16234 ,  C12N2710/16271 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q1/701 ,  C12Q1/705 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57446 ,  G01N2333/05 ,  G01N2333/521 ,  G01N2333/57 ,  G01N2800/52

摘要： A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.

公开(公告)号：US20190381167A1

公开(公告)日：2019-12-19

申请号：US16445481

申请日：2019-06-19

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  TESSA THERAPEUTICS PTE. LTD. ,  SINGAPORE HEALTH SERVICES PTE. LTD.

发明人： John CONNOLLY ,  Richard HOPKINS ,  Han Chong TOH

IPC分类号： A61K39/245 ,  G01N33/574 ,  C12Q1/70 ,  C12N7/00 ,  C12Q1/6886 ,  C12Q1/68 ,  A61K35/17

摘要： A method for predicting whether a patient will be a long-term survivor on treatment of a disease by adoptive cell transfer (ACT), is disclosed comprising: (i) analysing a blood-derived sample obtained from the patient for one or more prognostic markers of long-term survival on treatment of a disease by ACT, and; (ii) based on the analysis of step (i), predicting whether the patient will be a long-term survivor on treatment of the disease by ACT. Also disclosed are methods for treating a patient by ACT, methods for selecting a patient for treatment by ACT, and methods for selecting a patient for treatment of a disease by ACT.