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公开(公告)号：US11634503B2
公开(公告)日：2023-04-25
申请号：US16866408
申请日：2020-05-04
申请人： AGENSYS, INC. , SEAGEN INC.
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：USRE47103E1
公开(公告)日：2018-10-30
申请号：US15448507
申请日：2017-03-02
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09617346B2
公开(公告)日：2017-04-11
申请号：US14604658
申请日：2015-01-23
申请人： AGENSYS, INC.
发明人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： C07H21/04 , C07K16/40 , A61K39/395 , A61K45/06 , A61K47/48 , A61K51/10 , C07K16/30 , G01N33/68 , A61K39/00
CPC分类号： C07K16/40 , A61K39/39533 , A61K45/06 , A61K47/48607 , A61K47/6861 , A61K51/106 , A61K51/1075 , A61K2039/505 , C07H21/04 , C07K16/3069 , C07K2317/24 , C07K2317/565 , G01N33/6887 , A61K2300/00
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
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公开(公告)号：US10597463B2
公开(公告)日：2020-03-24
申请号：US15448430
申请日：2017-03-02
申请人： AGENSYS, INC.
发明人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： A61K48/00 , C07K16/40 , C07H21/04 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/30 , A61K47/68 , G01N33/68 , A61K39/00
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
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5.发明申请ANTIBODIES AND MOLECULES DERIVED THEREFROM THAT BIND TO STEAP-1 PROTEINS 审中-公开衍生自与STEAP-1蛋白质结合的抗体和分子公开(公告)号：US20150239986A1
公开(公告)日：2015-08-27
申请号：US14604658
申请日：2015-01-23
申请人： AGENSYS, INC.
发明人： Aya JAKOBOVITS , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K39/39533 , A61K45/06 , A61K47/48607 , A61K47/6861 , A61K51/106 , A61K51/1075 , A61K2039/505 , C07H21/04 , C07K16/3069 , C07K2317/24 , C07K2317/565 , G01N33/6887 , A61K2300/00
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization
摘要翻译： 描述了结合于新型STEAP-1蛋白质的抗体和衍生自其的变体及其变体，其中STEAP-1在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫
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公开(公告)号：US10669348B2
公开(公告)日：2020-06-02
申请号：US15895996
申请日：2018-02-13
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US08968742B2
公开(公告)日：2015-03-03
申请号：US13975214
申请日：2013-08-23
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合158P1D7蛋白的抗体药物偶联物（ADC）及其变体。 158P1D7在正常成人组织中表现出组织特异性表达，并且在胶质母细胞瘤，肺癌，膀胱癌和乳腺癌中异常表达。 因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US09926376B2
公开(公告)日：2018-03-27
申请号：US15085877
申请日：2016-03-30
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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