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公开(公告)号：US10669348B2
公开(公告)日：2020-06-02
申请号：US15895996
申请日：2018-02-13
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09962454B2
公开(公告)日：2018-05-08
申请号：US15069853
申请日：2016-03-14
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号： C07K16/18 , C12P21/08 , A61K39/395 , A61K47/48 , C07K16/30 , A61N5/10 , A61K47/68 , A61K39/00
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：USRE47103E1
公开(公告)日：2018-10-30
申请号：US15448507
申请日：2017-03-02
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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4.发明授权Nucleic acid molecules encoding antibody drug conjugates (ADC) that bind to 191P4D12 proteins 有权编码与191P4D12蛋白结合的抗体药物偶联物（ADC）的核酸分子公开(公告)号：US09314538B2
公开(公告)日：2016-04-19
申请号：US14798302
申请日：2015-07-13
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US08968742B2
公开(公告)日：2015-03-03
申请号：US13975214
申请日：2013-08-23
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合158P1D7蛋白的抗体药物偶联物（ADC）及其变体。 158P1D7在正常成人组织中表现出组织特异性表达，并且在胶质母细胞瘤，肺癌，膀胱癌和乳腺癌中异常表达。 因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US09926376B2
公开(公告)日：2018-03-27
申请号：US15085877
申请日：2016-03-30
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09078931B2
公开(公告)日：2015-07-14
申请号：US13830899
申请日：2013-03-14
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US11634503B2
公开(公告)日：2023-04-25
申请号：US16866408
申请日：2020-05-04
申请人： AGENSYS, INC. , SEAGEN INC.
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US10894090B2
公开(公告)日：2021-01-19
申请号：US15943527
申请日：2018-04-02
申请人： AGENSYS, INC. , SEAGEN INC.
发明人： Daulet Satpayev , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号： A61K39/395 , A61K47/68 , C07K16/30 , A61K39/00
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20130189286A1
公开(公告)日：2013-07-25
申请号：US13830899
申请日：2013-03-14
申请人： AGENSYS, INC. , Seattle Genetics
发明人： Daulet SATPAEV , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Jean Gudas , Aya Jakobovits , Michael Torgov , Zili An
IPC分类号： A61K47/48
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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