公开(公告)号：US20220073882A1

公开(公告)日：2022-03-10

申请号：US17455763

申请日：2021-11-19

Applicant: AJINOMOTO CO., INC.

Inventor： Shimpei OGAWA ,  Mayumi TOKUYAMA

IPC: C12N5/077

Abstract: Culturing a cartilage or bone progenitor cell in a medium containing a TGF-β signal inhibitor and FGF is effective for expansion culture of a cartilage or bone progenitor cell, and inducing differentiation of a cartilage or bone progenitor cell obtained by such a method is effective for producing a chondrocyte or osteocyte.

公开(公告)号：US20220401560A1

公开(公告)日：2022-12-22

申请号：US17685643

申请日：2022-03-03

Applicant: Ajinomoto Co., Inc.

Inventor： Ippei INOUE ,  Kenichiro ITO ,  Mayumi TOKUYAMA

IPC: A61K47/42

Abstract: Peptide-encapsulating ferritins including a peptide that is composed of 3 to 19 amino acid residues and satisfies the following requirement:
a) −10.2≤X≤5.9 and 445≤Y≤2,524
wherein X represents a charge of the peptide at pH 9, and I represents a chemical formula weight of the peptide are useful for transporting a peptide while avoiding destruction of cellular membrane, immunogenicity, and toxicity