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公开(公告)号:US20130023563A1
公开(公告)日:2013-01-24
申请号:US13627251
申请日:2012-09-26
Applicant: AJINOMOTO CO., INC.
Inventor: Kayo Matsumoto , Masayuki Sugiki , Tatsuhiro Yamada , Misato Noguchi , Masaru Takayanagi , Atsushi Takada , Tadakiyo Nakagawa , Wataru Miyanaga , Shin Muronoi , Shinya Taniguchi
IPC: C07D295/195 , A01N1/02 , C12N9/99 , C07D211/46 , A61K31/445 , C07D403/12 , A61K31/4025 , C07D401/12 , A61K31/454 , C07D211/60 , A61K31/4545 , C07D413/12 , A61K31/405 , A61K31/4155 , A61P7/02 , A61K31/40
CPC classification number: C07D207/08 , C07D207/16 , C07D209/08 , C07D211/46 , C07D211/60 , C07D231/14 , C07D295/195 , C07D401/12 , C07D413/12
Abstract: Provided are a novel amidine derivative having an activated blood coagulation factor X inhibitory activity, a production method thereof, a production intermediate therefor, and a pharmaceutical composition containing the amidine derivative. An amidinoaniline derivative represented by the following formula (1-1) or a pharmaceutically acceptable salt thereof: , and a pharmaceutical composition containing the amidinoaniline derivative or a pharmaceutically acceptable salt thereof.
Abstract translation: 提供具有活化凝血因子X抑制活性的新型脒衍生物,其制备方法,其制备中间体和含有脒衍生物的药物组合物。 由下式(1-1)表示的脒基苯胺衍生物或其药学上可接受的盐:在式(1-1)中,各符号如说明书>中所定义,含有脒基苯胺衍生物或 其药学上可接受的盐。