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公开(公告)号：US09227949B2
公开(公告)日：2016-01-05
申请号：US14567506
申请日：2014-12-11
Applicant: AJINOMOTO CO., INC.
Inventor： Takahiro Koshiba , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
IPC: A61K31/38 , C07D319/12 , C07D333/38 , C07D409/06 , C07D409/12 , C07D333/40
CPC classification number: A61K31/381 , A61K31/19 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4436 , A61K31/4535 , A61K31/4725 , A61K38/05 , C07D319/12 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12
Abstract: Compounds represented by the following formula (I); wherein each symbol is as defined in the specification, are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
Abstract translation: 由下式（I）表示的化合物; 其中每个符号如说明书中所定义，可用作具有丝氨酸蛋白酶抑制作用的高血糖抑制剂和用作糖尿病的预防或治疗药物。
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公开(公告)号：US20130023563A1
公开(公告)日：2013-01-24
申请号：US13627251
申请日：2012-09-26
Applicant: AJINOMOTO CO., INC.
Inventor： Kayo Matsumoto , Masayuki Sugiki , Tatsuhiro Yamada , Misato Noguchi , Masaru Takayanagi , Atsushi Takada , Tadakiyo Nakagawa , Wataru Miyanaga , Shin Muronoi , Shinya Taniguchi
IPC: C07D295/195 , A01N1/02 , C12N9/99 , C07D211/46 , A61K31/445 , C07D403/12 , A61K31/4025 , C07D401/12 , A61K31/454 , C07D211/60 , A61K31/4545 , C07D413/12 , A61K31/405 , A61K31/4155 , A61P7/02 , A61K31/40
CPC classification number: C07D207/08 , C07D207/16 , C07D209/08 , C07D211/46 , C07D211/60 , C07D231/14 , C07D295/195 , C07D401/12 , C07D413/12
Abstract: Provided are a novel amidine derivative having an activated blood coagulation factor X inhibitory activity, a production method thereof, a production intermediate therefor, and a pharmaceutical composition containing the amidine derivative. An amidinoaniline derivative represented by the following formula (1-1) or a pharmaceutically acceptable salt thereof: , and a pharmaceutical composition containing the amidinoaniline derivative or a pharmaceutically acceptable salt thereof.
Abstract translation: 提供具有活化凝血因子X抑制活性的新型脒衍生物，其制备方法，其制备中间体和含有脒衍生物的药物组合物。 由下式（1-1）表示的脒基苯胺衍生物或其药学上可接受的盐：在式（1-1）中，各符号如说明书>中所定义，含有脒基苯胺衍生物或 其药学上可接受的盐。
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Patent Agency Ranking
公开(公告)号：US09290487B2
公开(公告)日：2016-03-22
申请号：US14268323
申请日：2014-05-02
Applicant: Ajinomoto Co., Inc.
Inventor： Tadakiyo Nakagawa , Kayo Matsumoto , Sen Takeshita , Tomomi Yoshida , Munetaka Tokumasu , Hiroki Inoue , Kaori Kobayashi
IPC: C07D413/12 , C07D405/12 , C07D207/16 , C07D403/12 , C07D409/12 , C07D307/80 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D307/79
CPC classification number: C07D413/12 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D207/16 , C07D307/79 , C07D307/80 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.
Abstract translation: 提供由以下通式（I）表示的化合物或其药学上可接受的盐。 这种新型化合物具有糖原合成酶的活化能力，但能够将受体PPAR活性降低到很低的程度。 在该式中，Ar是芳香族碳环或杂环; Ar 2由以下任一个环等表示。
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公开(公告)号：US20140336376A1
公开(公告)日：2014-11-13
申请号：US14268323
申请日：2014-05-02
Applicant: Ajinomoto Co., Inc.
Inventor： Tadakiyo NAKAGAWA , Kayo Matsumoto , Sen Takeshita , Tomomi Yoshida , Munetaka Tokumasu , Hiroki Inoue , Kaori Kobayashi
IPC: C07D413/12 , C07D307/80 , C07D403/12 , C07D409/12 , C07D405/12 , C07D207/16
CPC classification number: C07D413/12 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D207/16 , C07D307/79 , C07D307/80 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.
Abstract translation: 提供由以下通式（I）表示的化合物或其药学上可接受的盐。 这种新型化合物具有糖原合成酶的活化能力，但能够将受体PPAR活性降低到很低的程度。 在该式中，Ar是芳香族碳环或杂环; Ar 2由以下任一个环等表示。
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公开(公告)号：US20160137633A1
公开(公告)日：2016-05-19
申请号：US15010404
申请日：2016-01-29
Applicant: Ajinomoto Co., Inc.
Inventor： Tadakiyo NAKAGAWA , Kayo Matsumoto , Sen Takeshita , Tomomi Yoshida , Munetaka Tokumasu , Hiroki Inoue , Kaori Kobayashi
IPC: C07D413/12 , C07D409/12 , C07D207/16 , C07D403/12 , C07D405/12 , C07D307/80
CPC classification number: C07D413/12 , A61K31/343 , A61K31/397 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/427 , A61K31/536 , C07D207/16 , C07D307/79 , C07D307/80 , C07D403/12 , C07D405/12 , C07D409/12
Abstract: Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe. In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.
Abstract translation: 提供由以下通式（I）表示的化合物或其药学上可接受的盐。 这种新型化合物具有糖原合成酶的活化能力，但能够将受体PPAR活性降低到很低的程度。 在该式中，Ar是芳香族碳环或杂环; Ar 2由以下任一个环等表示。
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公开(公告)号：US20160058734A1
公开(公告)日：2016-03-03
申请号：US14934386
申请日：2015-11-06
Applicant: AJINOMOTO CO., INC.
Inventor： Takahiro KOSHIBA , Munetaka Tokumasu , Taisuke Ichimaru , Koji Ohsumi , Tadakiyo Nakagawa , Tatsuhiro Yamada , Kayo Matsumoto , Tamotsu Suzuki
IPC: A61K31/381 , A61K31/4025 , A61K31/4535 , A61K38/05 , A61K31/397 , A61K31/4725 , A61K31/396 , A61K31/41 , A61K31/19 , A61K31/4436
CPC classification number: A61K31/381 , A61K31/19 , A61K31/396 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4436 , A61K31/4535 , A61K31/4725 , A61K38/05 , C07D319/12 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12
Abstract: Compounds represented by the following formula (I); wherein each symbol is as defined in the specification, are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
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公开(公告)号：US20150368242A1
公开(公告)日：2015-12-24
申请号：US14838419
申请日：2015-08-28
Applicant: Ajinomoto Co., Inc.
Inventor： Tamotsu Suzuki , Hiroki Inoue , Kayo Matsumoto , Takahiro Koshiba , Koji Ohsumi , Hiroki Ozawa , Munetaka Tokumasu , Masatsugu Noguchi
IPC: C07D471/04
CPC classification number: C07D471/04 , C07B59/002 , C07B2200/05
Abstract: An object is to provide a novel compound having a higher MGAT2 inhibitory activity than conventional compounds. A compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof is provided.
Abstract translation: 目的是提供具有比常规化合物更高的MGAT2抑制活性的新化合物。 提供由以下通式（I）表示的化合物或其药学上可接受的盐。
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