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公开(公告)号：US20140309135A1
公开(公告)日：2014-10-16
申请号：US14261953
申请日：2014-04-25
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/50 , G01N33/573 , G01N33/68 , C12Q1/48
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号：US20130130277A1
公开(公告)日：2013-05-23
申请号：US13709798
申请日：2012-12-10
Applicant: AJINOMOTO CO., INC.
Inventor： Naoyuki FUKUCHI , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC: C07D487/04 , G01N33/68
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 与三聚GTP结合蛋白的β亚基结合，包括降血糖化合物的糖尿病治疗剂，其特征在于能够结合三聚体GTP结合蛋白的β亚基作为活性成分等。
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公开(公告)号：US20130023563A1
公开(公告)日：2013-01-24
申请号：US13627251
申请日：2012-09-26
Applicant: AJINOMOTO CO., INC.
Inventor： Kayo Matsumoto , Masayuki Sugiki , Tatsuhiro Yamada , Misato Noguchi , Masaru Takayanagi , Atsushi Takada , Tadakiyo Nakagawa , Wataru Miyanaga , Shin Muronoi , Shinya Taniguchi
IPC: C07D295/195 , A01N1/02 , C12N9/99 , C07D211/46 , A61K31/445 , C07D403/12 , A61K31/4025 , C07D401/12 , A61K31/454 , C07D211/60 , A61K31/4545 , C07D413/12 , A61K31/405 , A61K31/4155 , A61P7/02 , A61K31/40
CPC classification number: C07D207/08 , C07D207/16 , C07D209/08 , C07D211/46 , C07D211/60 , C07D231/14 , C07D295/195 , C07D401/12 , C07D413/12
Abstract: Provided are a novel amidine derivative having an activated blood coagulation factor X inhibitory activity, a production method thereof, a production intermediate therefor, and a pharmaceutical composition containing the amidine derivative. An amidinoaniline derivative represented by the following formula (1-1) or a pharmaceutically acceptable salt thereof: , and a pharmaceutical composition containing the amidinoaniline derivative or a pharmaceutically acceptable salt thereof.
Abstract translation: 提供具有活化凝血因子X抑制活性的新型脒衍生物，其制备方法，其制备中间体和含有脒衍生物的药物组合物。 由下式（1-1）表示的脒基苯胺衍生物或其药学上可接受的盐：在式（1-1）中，各符号如说明书>中所定义，含有脒基苯胺衍生物或 其药学上可接受的盐。
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公开(公告)号：US08772281B2
公开(公告)日：2014-07-08
申请号：US13709798
申请日：2012-12-10
Applicant: Ajinomoto Co., Inc.
Inventor： Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
CPC classification number: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
Abstract: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
Abstract translation: 筛选具有降血糖作用的化合物的方法（以下称为“降血糖化合物”），含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说，可以列举一种能够将降血糖化合物 绑定到＆bgr 三聚GTP结合蛋白的亚单位，包含降血糖化合物的糖尿病治疗剂，其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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