公开(公告)号：US20220268790A1

公开(公告)日：2022-08-25

申请号：US17730484

申请日：2022-04-27

Applicant: AJINOMOTO CO., INC.

Inventor： Sachise KARAKAWA ,  Tomoyuki TAGAMI ,  Rumi NISHIMOTO ,  Shinya KIKUCHI ,  Akira IMAIZUMI ,  Koichi AZUMA ,  Tomoaki HOSHINO ,  Takaaki TOKITO ,  Hidenobu ISHII ,  Norikazu MATSUO

IPC: G01N33/94 ,  G01N33/68 ,  G16H10/40 ,  G16H50/30

Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.