公开(公告)号：US20220268790A1

公开(公告)日：2022-08-25

申请号：US17730484

申请日：2022-04-27

Applicant: AJINOMOTO CO., INC.

Inventor： Sachise KARAKAWA ,  Tomoyuki TAGAMI ,  Rumi NISHIMOTO ,  Shinya KIKUCHI ,  Akira IMAIZUMI ,  Koichi AZUMA ,  Tomoaki HOSHINO ,  Takaaki TOKITO ,  Hidenobu ISHII ,  Norikazu MATSUO

IPC: G01N33/94 ,  G01N33/68 ,  G16H10/40 ,  G16H50/30

Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.

公开(公告)号：US20250027949A1

公开(公告)日：2025-01-23

申请号：US18906699

申请日：2024-10-04

Applicant: AJINOMOTO CO., INC.

Inventor： Koichi AZUMA ,  Kenta MUROTANI ,  Tetsuro SASADA ,  Tomoyuki TAGAMI ,  Asami HAGIWARA ,  Akira IMAIZUMI ,  Sachise KARAKAWA ,  Mika KAWASAKI ,  Yohei MIYAGI ,  Tomohiko TAMURA ,  Haruhiro SAITO ,  Yoshiro NAKAHARA ,  Feifei WEI ,  Rika KASAJIMA ,  Huihui XIANG ,  Tatsuma BAN

IPC: G01N33/68

Abstract: An evaluating method includes an evaluating step of evaluating a relative pharmacological action of a combination of an immune checkpoint inhibitor and an anticancer drug as a combination drug compared with a pharmacological action of an immune checkpoint inhibitor alone in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hKyn, hTrp, Kyn, KynA, NP, QA, and XA in blood of the subject to be evaluated, or (ii) a value of a formula in the absence of use of an anticancer drug as a combination drug and a value of the formula in the presence of the use that are calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value and an explanatory variable on the presence or absence of the use.

公开(公告)号：US20230079759A1

公开(公告)日：2023-03-16

申请号：US18056531

申请日：2022-11-17

Applicant: Ajinomoto Co., Inc.

Inventor： Takashi HASHIMOTO ,  Yuichi NAKAHARA ,  Akira IMAIZUMI ,  Ippei INOUE ,  Hiroshi UMISHIO ,  Megumi YAMADA

IPC: G01N29/44 ,  G01N29/036 ,  G01N29/02

Abstract: A compatibility prediction method includes predicting compatibility between a prediction target food and a prediction target drink using: a model for predicting the compatibility between the prediction target food and the prediction target drink, and measurements that are values related to predetermined information obtained when a measuring instrument measures aroma components of the prediction target food and the prediction target drink or calculations calculated based on the measurements.

公开(公告)号：US20190227071A1

公开(公告)日：2019-07-25

申请号：US16373193

申请日：2019-04-02

Applicant: AJINOMOTO CO., INC.

Inventor： Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI ,  Kazutaka SHIMBO ,  Naoko ARASHIDA ,  Rumi NISHIMOTO

IPC: G01N33/574 ,  G01N33/49 ,  G01N33/487

Abstract: An evaluating method includes an evaluating step of evaluating a state of pancreatic cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of N-Me-bABA, bABA, GABA, N6-Acetyl-L-Lys, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, Homoarginine, Hypotaurine, Kinurenine, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.

公开(公告)号：US20180017545A1

公开(公告)日：2018-01-18

申请号：US15702936

申请日：2017-09-13

Applicant: AJINOMOTO CO., INC.

Inventor： Tadakazu HISAMATSU ,  Takanori KANAI ,  Toshifumi HIBi ,  Nobukazu ONO ,  Akira IMAIZUMI ,  Masaki HASHIMOTO ,  Maiko MORI ,  Michihide Uo

IPC: G01N33/49 ,  G01N33/50 ,  H04L1/00

CPC classification number: G01N33/492 ,  G01N33/50 ,  G01N33/6812 ,  G01N33/6827 ,  G01N33/721 ,  G01N2333/765 ,  G01N2800/065 ,  G01N2800/54 ,  G16H10/40 ,  G16H50/30 ,  H04L1/0061

Abstract: An evaluating method includes an evaluating step of evaluating a future risk of relapse of ulcerative colitis for a subject to be evaluated having ulcerative colitis in a remission phase using a concentration value of histidine, albumin, hemoglobin, or glutamic acid in blood of the subject.

公开(公告)号：US20250020656A1

公开(公告)日：2025-01-16

申请号：US18784141

申请日：2024-07-25

Applicant: AJINOMOTO CO., INC.

Inventor： Naoko ARASHIDA ,  Rumi NISHIMOTO ,  Kazutaka SHIMBO ,  Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI

IPC: G01N33/68 ,  G01N33/574 ,  G16H50/20

Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.

公开(公告)号：US20190204332A1

公开(公告)日：2019-07-04

申请号：US16233032

申请日：2018-12-26

Applicant: AJINOMOTO CO., INC.

Inventor： Takashi MIKAMI ,  Akira IMAIZUMI ,  Takayuki TANAKA ,  Yuki MIYAZAWA ,  Mina NAKAMURA ,  Kazuki NAKAGAWA ,  Takeshi FUJIEDA

IPC: G01N33/68 ,  G01N33/92 ,  G01N33/66 ,  G01N33/62

CPC classification number: G01N33/68 ,  G01N33/62 ,  G01N33/66 ,  G01N33/92

Abstract: An evaluating method includes an evaluating step of evaluating a state of ketosis in postpartum dairy cows for a dairy cow using at least one value of concentration values of Ala, Arg, Asn, Asp, BCAA, Cit, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, 3MeHis, Orn, Phe, Pro, Ser, Tau, Thr, Trp, Tyr, and Val and concentration values of ALB, ALT, AST, BHBA, BUN, Ca, gGTP, Glc, NEFA, T−Bil, TCHO, TG, and TP in blood of the dairy cow before parturition.

公开(公告)号：US20180017570A1

公开(公告)日：2018-01-18

申请号：US15715389

申请日：2017-09-26

Applicant: AJINOMOTO CO., INC.

Inventor： Naoko ARASHIDA ,  Rumi NISHIMOTO ,  Kazutaka SHIMBO ,  Hidehiro NAKAMURA ,  Natsumi NISHIKATA ,  Akira IMAIZUMI

IPC: G01N33/68 ,  G01N33/574 ,  G06F19/00

CPC classification number: G01N33/6812 ,  G01N33/57423 ,  G01N2800/56 ,  G06F19/3418 ,  G16H50/20

Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.

公开(公告)号：US20160253454A1

公开(公告)日：2016-09-01

申请号：US14988986

申请日：2016-01-06

Applicant: Ajinomoto Co., Inc.

Inventor： Takahiko MURAMATSU ,  Yutaka IHATA ,  Akira IMAIZUMI ,  Hiroshi YAMAMOTO ,  Etsuko MIYAGI ,  Fumiki HIRAHARA

IPC: G06F19/24 ,  G01N33/574

CPC classification number: G16B40/00 ,  G01N33/57411 ,  G01N33/57442 ,  G01N33/57449

Abstract: According to the method of evaluating female genital cancer of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and the state of female genital cancer including at least one of cervical cancer, endometrial cancer, and ovarian cancer in the subject is evaluated based on the concentration value of at least one of Thr, Ser, Asn, Gln, Pro, Gly, Ala, Cit, Val, Met, Ile, Leu, Tyr, Phe, His, Trp, Orn, Lys, and Arg contained in the measured amino acid concentration data of the subject.

Abstract translation: 根据本发明的女性生殖器癌的评价方法，测定从被评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据，包括宫颈癌中的至少一种的女性生殖器癌的状态 基于Thr，Ser，Asn，Gln，Pro，Gly，Ala，Cit，Val，Met，Ile，Leu，Tyr，Phe中的至少一种的浓度值来评估受试者的子宫内膜癌和卵巢癌， His，Trp，Orn，Lys和Arg包含在受试者的测量的氨基酸浓度数据中。

公开(公告)号：US20160026770A1

公开(公告)日：2016-01-28

申请号：US14877083

申请日：2015-10-07

Applicant: AJINOMOTO CO., INC.

Inventor： Takayuki TANAKA ,  Kenji NAGAO ,  Akira IMAIZUMI ,  Minoru YAMAKADO

IPC: G06F19/00

CPC classification number: G01N33/6812 ,  G16H50/30

Abstract: A method of evaluating lifestyle-related disease indicator includes (i) an obtaining step of obtaining amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated and (ii) an evaluating step of evaluating a state of an indicator of lifestyle-related disease for the subject using the concentration values of the amino acids of Gly and Tyr included in the amino acid concentration data of the subject obtained at the obtaining step.

Abstract translation: 评价生活方式相关疾病指标的方法包括：（i）获得从待评价对象收集的血液中获得氨基酸浓度值的氨基酸浓度数据的获取步骤，以及评价步骤， 使用包含在获得步骤中获得的受试者的氨基酸浓度数据中的Gly和Tyr的氨基酸的浓度值的对象的生活方式相关疾病的指标。